The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression

Cowen, Philip J.; Sherwood, Ann C.

doi:10.1177/0269881113482531

Cited by 104 publications

(79 citation statements)

References 91 publications

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“…The role of 5-HT in relation to cognition is supported by the importance of appropriate levels of tryptophan, the biochemical precursor of 5-HT, for normal cognitive functioning [58,59] and the cognitive and emotional consequences of tryptophan depletion in genetically susceptible individuals [60,61].…”

Section: Cognitionmentioning

confidence: 99%

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

Zhao

Zhang

Yang

et al. 2015

Behavioural Brain Research

111

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Serotonergic neurons in the dorsal raphe nucleus (DRN) play an important role in regulation of many physiological functions. The lateral nucleus of the habenular complex (LHb) is closely connected to the DRN both morphologically and functionally. The LHb is a key regulator of the activity of DRN serotonergic neurons, and it also receives reciprocal input from the DRN. The LHb is also a major way-station that receives limbic system input via the stria medullaris and provides output to the DRN and thereby indirectly connects a number of other brain regions to the DRN. The complex interactions of the LHb and DRN contribute to the regulation of numerous important behavioral and physiological mechanisms, including those regulating cognition, reward, pain sensitivity and patterns of sleep and waking. Disruption of these functions is characteristic of major psychiatric illnesses, so there has been a great deal of interest in how disturbed LHb-DRN interactions may contribute to the symptoms of these illnesses. This review summarizes recent research related to the roles of the LHb-DRN system in regulation of higher brain functions and the possible role of disturbed LHb-DRN function in the pathogenesis of psychiatric disorders, especially depression.

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Section: Cognitionmentioning

confidence: 99%

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

Zhao

Zhang

Yang

et al. 2015

Behavioural Brain Research

111

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“…(for review see Meneses and LiySalmeron (2012); see also Martin and Sibson, 2008). As diverse serotonergic manipulations alter memory (Hindi Attar et al, 2012), certainly, 5-HT 1A , 5-HT 2A/2C , 5-HT 3 , 5-HT 4 , 5-HT 6 , and 5-HT 7 receptors have attracted more scientific interest regarding memory (Bockaert et al, 2008(Bockaert et al, , 2011Boulougouris V and Robbins, 2010;Cammarota et al, 2008;Cowen and Sherwood, 2013;Meneses, , 2003King et al, 2008;Ö gren et al, 2008;Roth et al, 2004;Terry et al, 2008;Volk et al, 2010;Williams et al, 2002). In addition, 5-HT 1A/1B , 5-HT 2A/2C , 5-HT 3 , 5-HT 4 , 5-HT 6 , and 5-HT 7 receptors have in common that their agonists and/or antagonists seem to have promnesic and/or antiamnesic effects (Bockaert et al, 2008;Borg, 2008;Bombardi and Di Giovanni, 2013;Elvander-Tottie et al, 2009;Hajjo et al, 2012;Meneses, , 2003King et al, 2008;Ö gren et al, 2008;Pennanen et al, 2013;Roth et al, 2004;Ruiz and Oranias, 2010;Sawyer et al, 2012;Terry et al, 2008;Thompson et al, 2013;Timotijević et al, 2012;van Praag, 2008;Youn et al, 2009;Rhim, 2011a, 2011b;Yun et al, 2010;Zhang et al, 2013).…”

Section: -Ht Pathways Receptors and Transporter: Memory Functions mentioning

confidence: 99%

Neurotransmitters and Memory

Meneses

2014

Identification of Neural Markers Accompanying Memory

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“…For at least 2 classes of drug, serotonergic and dopaminergic, both of which are monoaminergic, existing evidence from human studies supports the possibility for enhancing motor outcome after stroke. Serotonin normally plays a role in modulating multiple cognitive functions, particularly response inhibition and memory consolidation, and modulates the impact of punishment-related signals on learning and emotion [5][6][7]. Recent reports suggest potential clinical utility of selective serotonin reuptake inhibitor (SSRI) drugs for promoting improved motor outcome after stroke.…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial

Babul¹,

Hassanuzzaman²,

Ahammed³

et al. 2017

AJPN

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Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p<.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.

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The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression

Abstract: Larger, consistently designed studies are needed to understand the roles of 5-HT in cognition in healthy and depressed individuals. Efforts to target specific 5-HT receptors to improve cognitive outcomes are warranted.

Cited by 104 publications

References 91 publications

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

Neurotransmitters and Memory

Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial

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