The role of serum albumin/globulin ratio in combination with prognostic risk indexes of febrile neutropenia

Abstract

Objectives:The aim of this study was to evaluate the effect of the serum albumin/ globulin ratio (AGR) on the 30-day mortality of febrile neutropenia (FEN). The second aim of the study was to evaluate the effect of the combination of the AGR with the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) risk indexes on 30-day mortality of FEN.Methods: A retrospective study evaluating the effect of serum AGR, MASCC and CISNE scores on 30-day FEN mortality.Results: A total of 137 FEN episodes in 120 patients were included in this study.Nineteen patients (14%) died within the first 30 days of FEN episodes. The 30day mortality rate was calculated as 4% in patients with high AGR and 23% in patients with low AGR (P = .002). According to the MASCC and CISNE risk scores, the mortality rates in low-risk patients were 8% and 6%, respectively, and in the high-risk group 22% and 29%, respectively (P = .024 vs P < .001). In the group of patients with MASCC <21 and CISNE ≥3, the 30-day mortality rate was 7%, when the AGR was >1.13, and in those with AGR ≤1.13 mortality rate increased to 50% (P = .012). Conclusion:A low AGR in a patient with FEN was found to be associated with an increased risk of 30-day mortality. Combining the AGR with MASCC and CISNE risk indexes might increase the predictive value of these scoring systems on 30-day mortality. What's known• MASCC and CISNE risk indices are used in the prognosis of febrile neutropenia.• However, the specificity and sensitivity of both indexes are limited.• More effective risk scoring is needed in the management of febrile neutropenia. What's new• Combining the AGR with MASCC and CISNE risk indexes might increase the predictive value of these scoring systems on 30-day mortality. How to cite this article: Sütcüoğlu O, Akdoğan O, Gürler F, et al. The role of serum albumin/globulin ratio in combination with prognostic risk indexes of febrile neutropenia. Int J Clin

Alpha‐2‐Heremans‐Schmid‐glycoprotein (AHSG) a potential biomarker associated with prognosis of chromophobe renal cell carcinoma: The PROPOLIS study

“…Cytohubba in Cytoscape software was used to select the top hub genes from PPI network (Figure 8A). The hub genes were fibrinogen alpha chain (FGA, MIM: 134820), fibrinogen beta chain (FGB, MIM: 134830), alpha 2‐HS glycoprotein (AHSG, MIM: 138680), albumin (ALB, MIM: 103600), alpha‐1‐microglobulin/bikunin precursor (AMBP, MIM: 176870), serpin family A member 1 (SERPINA1, MIM: 107400), apolipoprotein H (APOH, MIM: 138700), inter‐alpha‐trypsin inhibitor heavy chain 2 (ITIH2, MIM: 146640), histidine‐rich glycoprotein (HRG, MIM: 142640), and transthyretin (TTR, MIM: 176300), which mostly were serum proteins and plasma proteins, mainly functioning in coagulation, protease inhibitors, transport or inflammatory regulation 25–33 …”

“…The hub genes were fibrinogen alpha chain (FGA, MIM: 134820), fibrinogen beta chain (FGB, MIM: 134830), alpha 2-HS glycoprotein (AHSG, MIM: 138680), albumin (ALB, MIM: 103600), alpha-1microglobulin/bikunin precursor (AMBP, MIM: 176870), serpin family A member 1 (SERPINA1, MIM: 107400), apolipoprotein H (APOH, MIM: 138700), inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2, MIM: 146640), histidine-rich glycoprotein (HRG, MIM: 142640), and transthyretin (TTR, MIM: 176300), which mostly were serum proteins and plasma proteins, mainly functioning in coagulation, protease inhibitors, transport or inflammatory regulation. [25][26][27][28][29][30][31][32][33] To decide the significant biomarkers, the KM survival curve was constructed for the top 10 hubs. Only the expression of AHSG was found to be associated with chRCC.…”

C-reactive protein to albumin ratio, albumin to globulin ratio and platelet to lymphocyte ratio in patients with spondyloarthritis

“…A meta-analysis showed that low pretreatment AGR was related poor prognosis in cancers (18). Sütçüoğlu et al showed that low AGR was related with increased risk of mortality in febrile neutropenia (19).…”