2023
DOI: 10.3390/ijms24021671
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The Role of Serum Calprotectin in Defining Disease Outcomes in Non-Systemic Juvenile Idiopathic Arthritis: A Pilot Study

Abstract: Serum calprotectin (MRP8/14) is currently being studied as a promising biomarker of disease activity and outcome in patients with juvenile idiopathic arthritis (JIA) but the data in the literature are conflicting. The aim of our study was to investigate the potential role of serum calprotectin as biomarker of disease activity and flare/remission in a group of nsJIA patients during a follow-up period of 18 months. In this prospective longitudinal study, two groups of patients with ns-JIA (55 active patients and… Show more

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Cited by 2 publications
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“…D'Angelo el al. ( 16 ). measured sCal using a different type of immunoenzymatic assay (Calprest NG from Eurospital Diagnostics).…”
Section: Discussionmentioning
confidence: 99%
“…D'Angelo el al. ( 16 ). measured sCal using a different type of immunoenzymatic assay (Calprest NG from Eurospital Diagnostics).…”
Section: Discussionmentioning
confidence: 99%
“…Lower levels of S100A8/A9 post-treatment, which are independent of inflammation mark- Variable levels of S100A8 and S100A9 in serum, plasma, or feces can be potential biomarkers of disease initiation, progression, response to therapy, and phenotype change. S100A8/A9 has been identified to be a biomarker in the inflammatory stages of numerous diseases such as ulcerative colitis and acute respiratory infections [34][35][36][37][38][39]. In addition, plasma levels of S100A8/A9 can be a surrogate of blood neutrophil count (below 1 × 10 9 /L) as a cost-effective, easier, and at-home method for monitoring and evaluating patients compared with flow cytometry [40].…”
Section: S100a8 and S100a9 As A Biomarker In Hmsmentioning
confidence: 99%