2018
DOI: 10.14800/macrophage.1435
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The role of Siglec-1 in HIV-1/macrophage interaction

Abstract: Although CD4 T-cells are a major target for HIV, recent work has demonstrated the ability of macrophages despite expressing relatively low levels of CD4, to be a target of the virus. Our recent study has found that the presence of growth factors not only play a role in the phenotype of these monocyte-derived-macrophages, but also are an important aspect of the permissiveness of these cells to infection. The work utilized cellular and biophysical methods to examine Siglec-1 on macrophages as a primary receptor … Show more

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Cited by 4 publications
(1 citation statement)
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“…Notwithstanding, hybrid and complex glycans can induce a more robust immune reaction (Lin et al, 2013). The presence of sialic acid in the N-and O-glycans of HEK-293-derived VLPs may also encourage macrophage recognition and consequent presentation to APCs (Jobe et al, 2016;Lavado-Garcia et al, 2022). It is important to note that upon transfection of HEK-293 cells, the formation of small extracellular vesicles (EVs) was reported, and this can affect glycan density and bioprocessing (Lavado-Garcia et al, 2022).…”
Section: Major Developments On Hiv-1-based Vlp Productionmentioning
confidence: 99%
“…Notwithstanding, hybrid and complex glycans can induce a more robust immune reaction (Lin et al, 2013). The presence of sialic acid in the N-and O-glycans of HEK-293-derived VLPs may also encourage macrophage recognition and consequent presentation to APCs (Jobe et al, 2016;Lavado-Garcia et al, 2022). It is important to note that upon transfection of HEK-293 cells, the formation of small extracellular vesicles (EVs) was reported, and this can affect glycan density and bioprocessing (Lavado-Garcia et al, 2022).…”
Section: Major Developments On Hiv-1-based Vlp Productionmentioning
confidence: 99%