The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients

Uzlu, Dilek; Erdöl, Hidayet; Somuncu, Ahmet Mehmet; OZBAY, Ahmet Duhan; Kola, Mehmet; Köse, Büşra

doi:10.1007/s10792-020-01557-4

Cited by 5 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of 32 studies included in this meta-analysis, 26 studies [ 3 – 19 , 22 – 28 , 30 , 35 ] were conducted in Turkey, four in China [ 20 , 21 , 29 , 31 ], one study in India [ 37 ], and one in Korea [ 38 ]. Concerning document language, 31 studies were in English [ 3 – 31 , 37 , 38 ], and one study in Turkish [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Concerning document language, 31 studies were in English [ 3 – 31 , 37 , 38 ], and one study in Turkish [ 35 ]. In terms of study design, there were 11 prospective [ 4 – 6 , 11 , 13 , 16 , 21 , 24 , 27 , 28 , 30 ] and 21 retrospective studies [ 3 , 7 – 10 , 12 , 14 , 15 , 17 – 20 , 22 , 23 , 25 , 26 , 29 , 31 , 35 , 37 , 38 ]. Overall, 3242 healthy controls and 3378 patients with eye diseases were enrolled in the selected studies.…”

Section: Resultsmentioning

confidence: 99%

“…The general characteristics of the selected studies and their quality score are presented in Table 1 . We found six studies on KC [ 5 , 11 , 13 , 15 , 23 , 27 ], six studies on pterygium [ 12 , 16 , 17 , 19 , 22 , 35 ], four studies on DED [ 6 , 21 , 24 , 28 ], and four studies on iERM [ 7 , 8 , 10 , 30 ]. Also, the association between NLR and glaucoma was investigated in 12 studies [ 3 , 4 , 9 , 14 , 18 , 20 , 25 , 26 , 29 , 31 , 37 , 38 ], of which four were conducted among East Asian patients [ 20 , 29 , 31 , 38 ] and eight among Caucasian patients [ 3 , 4 , 9 , 14 , 18 , 25 , 26 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…It may cause decreased visual acuity, metamorphopsia, monocular diplopia, macropsia, and micropsia [ 40 ]. Several researchers have reported that NLR levels were higher in iERM patients than healthy controls [ 7 , 8 , 10 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

Shirvani

Soufi

Nouralishahi

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

The neutrophil to lymphocyte ratio (NLR) reflects a dynamic relationship between the innate (neutrophils) and adaptive (lymphocytes) cellular immune response. This systematic review and meta-analysis was conducted to critically evaluate the literature regarding the use of the NLR as a reliable means to detect several ocular disorders. Our study was registered with the PROSPERO (ID: CRD42022314850). Three databases, including PubMed, Embase, Scopus, and the Web of Science, were searched on September 9, 2022, with no restrictions on the article’s language. Finally, 32 articles were recognized as eligible for our meta-analysis. We found that patients with eye diseases had significantly elevated levels of NLR in comparison to healthy controls (SMD =0.53, 95% CI =0.35-0.71, P < 0.001 ). In subgroup analysis, patients with keratoconus (SMD =0.69; 95% CI =0.33-1.05, P < 0.001 ), glaucoma (SMD =0.56, 95% CI =0.25-0.87, P < 0.001 ), pterygium (SMD =0.14; 95% CI =0.01-0.26, P < 0.001 ), and idiopathic epiretinal membrane (SMD =0.14; 95% CI =0.01-0.26, P < 0.001 ) had higher levels of NLR compared to healthy controls. However, NLR levels of patients with dry eye disease were similar to healthy controls (SMD =0.32, 95% CI = -0.49-1.13, P = 0.435 ). It can be said that NLR is a valuable marker of systemic inflammation, which is significantly increased in many eye disorders, suggesting that inflammation plays a key role in the pathophysiology of these diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

Shirvani

Soufi

Nouralishahi

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Furthermore, these serum in ammatory biomarkers have been linked to the onset of ocular disorders such as dry eye disease (DED), keratoconus, retinal vein occlusion (RVO) and central retinal artery occlusions (CRVO) Page 3/12 [14][15][16][17][18]. While the role of NLR and PLR have been previously explored in iERM [19,20], the current study aimed to evaluate the probable relationship between MLR, NLR and PLR serum in ammatory biomarkers in participants with iERM.…”

Section: Introductionmentioning

confidence: 99%

Blood Inflammatory Biomarkers in Participants with Idiopathic Epiretinal Membranes Running Title: Blood Biomarkers for iERM

Qin

You²,

Shang

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: To evaluate the levels of monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with Idiopathic Epiretinal Membrane (iERM). Methods:This retrospective study comprised of participants with iERM and participants with cataract. The values of MLR, NLR, PLR and from participants’ peripheral blood were assessed among groups. The best cutoff value of MLR, NLR, and PLR in iERM was found by performing a receiver operating characteristic (ROC) curve analysis and determining the optimum cutoff value for each variable. Results: In total, 95 participants with iERM were included in the study group, and 61 participants with senile cataract were included as controls. The lymphocyte count in the iERM group was significantly lower than the control group (1.69±0.63 vs. 1.95±0.53, p=0.003). The monocyte count in the iERM group was significantly higher thanthe control group (0.39±0.11 vs. 0.31±0.10, p<0.001). The area under the curve of MLR, NLR and PLR in differentiating patients with IERM and controls was 0.782, 0.645, and 0.657, respectively, according to ROC. The best cut-off value of MLR was >0.18, with sensitivity and specificity of 74.7% and 75.4% respectively. The NLR was >2.06, with a sensitivity and specificity of 50.5% and 83.6% respectively. The PLR was >95.89, with a sensitivity and specificity of 86.3% and 41.0% respectively. Conclusion:The findings of this study suggest that systemic inflammation may be associated with iERM. IERM patients may be prone to have high MLR, NLR and PLR values.

show abstract

Intraoperative efficacy and clinical outcomes of two commercial staining solutions used in idiopathic epiretinal membrane surgery

et al. 2021

View full text Add to dashboard Cite

The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients

Cited by 5 publications

References 17 publications

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

Blood Inflammatory Biomarkers in Participants with Idiopathic Epiretinal Membranes Running Title: Blood Biomarkers for iERM

Intraoperative efficacy and clinical outcomes of two commercial staining solutions used in idiopathic epiretinal membrane surgery

Contact Info

Product

Resources

About