The role of single ECG, creatine kinase, and CKMB in diagnosing patients with acute chest pain

Diagnostic Performance of Initial Salivary Alpha-Amylase Activity for Acute Myocardial Infarction in Patients with Acute Chest Pain

“…Although both cardiac troponins and creatinine kinase-MB fraction (CK-MB) are sensitive and specific markers of myocardial damage, it takes approximately 4-6 h and even up to 10-12 h for these biomarkers to be detectable in the circulation after the onset of chest pain (4,5). As some patients present with RECEIVED: 3 December 2010; FINAL SUBMISSION RECEIVED: 25 April 2011; ACCEPTED: 5 June 2011 atypical features, the initial ECG is diagnostic in only about 50% of AMI cases (6). Thus, in the absence of overt ST-elevation myocardial infarction (STEMI), there is still substantial diagnostic uncertainty in the early presentation.…”

An HPLC method for determination of inosine and hypoxanthine in human plasma from healthy volunteers and patients presenting with potential acute cardiac ischemia

“…Cardiovascular disease is the leading cause of mortality in the world and includes MI, which can be presaged by acute cardiac ischemia [2][3][4][5]. In a patient suspected of having an MI or on-going acute cardiac ischemia, standard diagnostic procedures include patient history and physical exam, an electrocardiogram (ECG) and sequential assessment of biomarkers of myocardial damage [6][7][8].…”

The sensitivity of cardiac markers stratified by symptom duration

“…Other investigators have combined a marker value with EKG results and have demonstrated increased sensitivity for diagnosing acute MI (21,25,26). In a study utilizing CK and CK-MBs, Young demonstrated that a combination of these cardiac markers drawn upon admission to the ED and combined with an initial EKG conveyed a sensitivity of 79% for acute MI (1,26).…”