The role of sleep deprivation in streptozotocin-induced Alzheimer’s disease-like sporadic dementia in rats with respect to the serum level of oxidative and inflammatory markers

Arjmandi-Rad, Shirin; Zarrindast, Mohammad‐Reza; Shadfar, Sina; Nasehi, Mohammad

doi:10.1007/s00221-022-06471-y

Cited by 3 publications

(4 citation statements)

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“…Inflammatory cytokines can communicate with the central nervous system (CNS) through neural and cellular mechanisms, resulting in altered CNS activity and disrupted sleep regulation [45][46][47]. Preclinical studies have shown that sleep deprivation or disturbance can induce the release of inflammatory cytokines such as interleukin-1 (IL-1), IL-6 and TNF-a in peripheral blood and various brain regions [48][49][50]. In animal models, interleukin-4 (IL-4) and IL-10, which are considered to be anti-inflammatory cytokines, have been found to reduce the amount of non-rapid eye movement (NREM) sleep [51].…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial

Wang

et al. 2023

Pain Ther

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Introduction This study was conducted to observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on the postoperative sleep quality of patients undergoing gastrointestinal tumor surgery and to verify the possible mechanism. Methods Eighty-three patients were allocated to the TEAS or Sham group. Patients in the TEAS group received TEAS treatment (disperse-dense waves; frequency, 2/100 Hz) on bilateral Shenmen (HT7), Neiguan (PC6) and Zusanli (ST36) points for 30 min each time, total three times in the perioperative period. In the Sham group, electrodes were placed; however, no current was given. Sleep quality was assessed on the day before surgery (P1) and the first and third days after surgery (D1 and D3) using the Pittsburgh Sleep Quality Index (PSQI) and Athens Insomnia Scale (AIS). Postoperative pain was assessed using visual analog scale (VAS) 72 h postoperatively. The incidences of abdominal distension, dizziness, postoperative nausea and vomiting (PONV) and pulmonary complications were recorded. Serum levels of inflammatory cytokines and the expression of key factors of oxidative stress and key molecules of the nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signal pathway were measured. Results TEAS ameliorated sleep quality at D1 and D3 (PSQI P < 0.05, AIS P < 0.05) and decreased postoperative pain as demonstrated by lower VAS scores compared to the Sham group ( P < 0.05). The incidences of abdominal distension and PONV were also lower in the TEAS group. Markers of oxidative stress were increased ( P < 0.05), and the serum concentration of interleukin-6 (IL-6) was significantly lower in the TEAS group. The key mediators of the Nrf2/ARE pathway were enhanced after TEAS. Conclusion Perioperative TEAS improved postoperative sleep quality, reduced postoperative pain and alleviated postoperative adverse effects in patients undergoing laparoscopic gastrointestinal tumor surgery resection. This may be associated with activating Nrf2/ARE signal pathway and decreasing its inflammatory actions. Trial registration Chinese Clinical Trial Registry ( http://www.chictr.org.cn/index.aspx ), ChiCTR2100054971.

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Section: Discussionmentioning

confidence: 99%

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial

Wang

et al. 2023

Pain Ther

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“…21,22 This chronic low-grade inflammation has been associated with cognitive decline and an increased risk of cognitive disorders such as dementia and Alzheimer's disease. 23 Recent advances in molecular biology have shed light on the interplay between sleep duration and gene expression. 24,25 Sleep patterns have been shown to influence the expression of various genes involved in immune regulation, stress response, and neuronal function.…”

Section: Introductionmentioning

confidence: 99%

“… 21 , 22 This chronic low‐grade inflammation has been associated with cognitive decline and an increased risk of cognitive disorders such as dementia and Alzheimer's disease. 23 …”

Section: Introductionmentioning

confidence: 99%

“…Research indicated that inadequate sleep can trigger an inflammatory response in the body, leading to increased levels of pro‐inflammatory cytokines and other markers of inflammation 21,22 . This chronic low‐grade inflammation has been associated with cognitive decline and an increased risk of cognitive disorders such as dementia and Alzheimer's disease 23 …”

Section: Introductionmentioning

confidence: 99%

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Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

You,

Li,

Zhang

et al. 2024

CNS Neurosci Ther

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AimsThe molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) and explore cellular mechanisms in mice.MethodsSystemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics and single‐cell transcriptomics (GSE137665) to examine how short sleep exposure influenced the molecular pathways associated with inflammation in the brain. To explore the signaling pathways and biological processes of sleep deprivation, we carried out enrichment analyses utilizing the GO and KEGG databases.ResultsPopulation results showed that, compared with normal sleep group, severe short sleep was associated with lower cognitive ability in all the four tests. Moreover, a higher SII level was correlated with lower scores of cognitive tests. In mice study, elevated activation of the inflammatory pathway was observed in cell subgroups of neurons within the sleep deprivation and recovery sleep cohorts. Additionally, heightened expression of oxidative stress and integrated stress response pathways was noted in GABAergic neurons during sleep deprivation.ConclusionThis study contributed to the understanding of the influence of short sleep on cognitive function and its cellular mechanisms.

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The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats

et al. 2023

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The role of sleep deprivation in streptozotocin-induced Alzheimer’s disease-like sporadic dementia in rats with respect to the serum level of oxidative and inflammatory markers

Cited by 3 publications

References 69 publications

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats

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