The Role of Soluble Interleukin‐4 Receptor and Interleukin‐5 Antibody in Preventing Late‐Phase Allergy‐Induced Eustachian Tube Dysfunction

Pollock, Hoke W.; Ebert, Charles S.; Dubin, Marc G.; White, David R.; Prazma, Jiri; Pillsbury, Harold C.

doi:10.1067/mhn.2002.126901

Cited by 21 publications

(15 citation statements)

References 19 publications

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“…6). This assumption was confirmed in an experimental model of OME, 112 where the late-phase allergic inflammatory response was prevented by pretreatment with IL-5 antibodies or soluble receptors for IL-4.…”

Section: Il-5 In Otitis Mediamentioning

confidence: 66%

“…Studies on IL-4 in experimental OME 93,112 demonstrated the involvement of IL-4 in regulation of different types of otitis media. In trans-tympanically challenged animals the expression of IL-4 was detected during acute and chronic otitis media, with the predominance of IL-4 ' cells in the acute form.…”

Section: Tgf-b In Otitis Mediamentioning

confidence: 99%

“…93 The trans-tympanical injection of soluble receptors for IL-4 prevented the allergic Eustachian tube dysfunction and formation of effusion in the middle ear cleft. 112 The involvement of IL-4 in regulation of MUC5AC and MUC5B mucin gene expression and secretion has been shown in human airways. 113 Á 115 The secreted mucins, MUC5AC and MUC5B, are presented in the middle ear mucosa and effusions in patients with chronic OME.…”

Section: Tgf-b In Otitis Mediamentioning

confidence: 99%

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The immunoregulatory and allergy‐associated cytokines in the aetiology of the otitis media with effusion

Smirnova

Birchall

Pearson

2004

Mediators of Inflammation

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Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. Cytokines are the central molecular regulators of middle ear inflammation and can switch the acute phase of inflammation in the chronic stage and induce molecular-pathological processes leading to the histopathological changes accompanying OME. In this review we present cytokines identified in otitis media, immunoregulatory [interleukin (IL)-2, IL-10, transforming growth factor-beta]) and allergy associated (IL-4, IL-5, granulocyte-macrophage colony-stimulating factor), as crucial molecular regulators, responsible for chronic inflammation in the middle ear and the chronic condition of OME.

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Section: Il-5 In Otitis Mediamentioning

confidence: 66%

Section: Tgf-b In Otitis Mediamentioning

confidence: 99%

Section: Tgf-b In Otitis Mediamentioning

confidence: 99%

See 1 more Smart Citation

The immunoregulatory and allergy‐associated cytokines in the aetiology of the otitis media with effusion

Smirnova

Birchall

Pearson

2004

Mediators of Inflammation

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show abstract

mentioning

confidence: 99%

“…112 The involvement of IL-4 in regulation of MUC5AC and MUC5B mucin gene expression and secretion has been shown in human airways.…”

mentioning

confidence: 99%

The Relation between Tympanostomy Tube Otorrhea and Types of Immune Cells in Middle Ear Effusion in Children with Otitis Media with Effusion

Lim¹,

Hyun²,

Kim³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. Cytokines are the central molecular regulators of middle ear inflammation and can switch the acute phase of inflammation in the chronic stage and induce molecular Á /pathological processes leading to the histopathological changes accompanying OME. In this review we present cytokines identified in otitis media, immunoregulatory [interleukin (IL)-2, IL-10, transforming growth factorb]) and allergy associated (IL-4, IL-5, granulocyte Á / macrophage colony-stimulating factor), as crucial molecular regulators, responsible for chronic inflammation in the middle ear and the chronic condition of OME.

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Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

Juszczak¹,

Aubin-Pouliot

Sharon

et al. 2019

Int Forum Allergy Rhinol

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Background: Sinonasal pathology is frequently cited as a cause of eustachian tube dysfunction (ETD), despite a lack of evidence. Using a large, nationally representative sample, we investigated whether abnormal tympanometry, an objective marker of ETD, was associated with infectious, allergic, and exposure-related sinonasal risk factors. Methods:Relevant data were extracted from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). Tympanometric types (A, B, and C) were determined using peak pressure and compliance values. Participants with a type B or C tympanogram in at least one ear were classified as having ETD. Demographic and clinicopathologic risk factors with putative associations with ETD were determined. Statistical analysis, including regression modeling, was performed using Stata (version 15.1) to determine the correlation between sinonasal factors and ETD. Results:The final analysis included 1253 subjects and 19 variables. We controlled for demographic data including age, gender, race, and income. In both univariate and multivariate logistic regression, statistically significant correlations were found between abnormal tympanometric values and: (1) having a persistent cold/flu in the last 12 months (univariate: adjusted odds ratio [OR], 2.42; p = 0.006; multivariate: adjusted OR, 2.15; p = 0.006); and (2) experiencing "hay fever" (ie, allergic rhinitis) within the last 12 months (univariate: adjusted OR, 1.95; p = 0.021; multivariate: adjusted OR, 1.71; p = 0.039). Conclusion:Using a large, representative data set, we identified significant correlations between ETD and (1) persistent cold/flu symptoms and (2) self-reported allergic rhinitis. C 2019 ARS-AAOA, LLC.

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The Role of Soluble Interleukin‐4 Receptor and Interleukin‐5 Antibody in Preventing Late‐Phase Allergy‐Induced Eustachian Tube Dysfunction

Abstract: These data demonstrate that the late-phase allergic inflammatory response that leads to subsequent formation of ETD and MEE is prevented by pretreatment with sIL-4R and, more modestly, with IL-5Ab.

Cited by 21 publications

References 19 publications

The immunoregulatory and allergy‐associated cytokines in the aetiology of the otitis media with effusion

The immunoregulatory and allergy‐associated cytokines in the aetiology of the otitis media with effusion

The Relation between Tympanostomy Tube Otorrhea and Types of Immune Cells in Middle Ear Effusion in Children with Otitis Media with Effusion

Sinonasal risk factors for eustachian tube dysfunction: Cross‐sectional findings from NHANES 2011‐2012

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