2004
DOI: 10.1016/j.cbpc.2004.04.006
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The role of somatostatins in the regulation of metabolism in fish

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Cited by 51 publications
(23 citation statements)
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“…Lately, glucagon (Staub et al 1953), and presprosomatostatin (Hobart et al 1980) were discovered in fish BB. Since then numerous studies have been focussed on the characterization of the effect of these pancreatic peptides on fish metabolism, growth and reproduction (Mommsen and Busby 2006;Plisetskaya et al 1993;Sheridan and Hagemeister 2010;Sheridan and Kittilson 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Lately, glucagon (Staub et al 1953), and presprosomatostatin (Hobart et al 1980) were discovered in fish BB. Since then numerous studies have been focussed on the characterization of the effect of these pancreatic peptides on fish metabolism, growth and reproduction (Mommsen and Busby 2006;Plisetskaya et al 1993;Sheridan and Hagemeister 2010;Sheridan and Kittilson 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Somatostatin (SS) is the major inhibitor of GH secretion (1), and its regulation and function have been reviewed elsewhere (19,22,47,60). In goldfish, three cDNAs encoding for pro-SS (PSS) have been cloned (21) (21).…”
mentioning
confidence: 99%
“…An increase in the sensitivity of cells to SS would initiate a series of metabolic and growth counterregulatory measures that would result in a shift away from the anabolic/growth-promoting actions of GH and INS (e.g., cellular uptake of amino acids, elevated protein synthesis, and production of IGF-I) (26, 32) toward a pattern of catabolism. At the level of the pancreas, SS inhibits INS release (29). At the level of the liver, enhanced sensitivity to SS would promote its catabolic actions (e.g., glycogenolysis and lipolysis) (29).…”
Section: Discussionmentioning
confidence: 99%
“…The distribution of SSTRs may underlie tissue-specific responses of SSs. Despite the importance of SSs in the growth, development, and metabolism of organisms (19,23,29,32), relatively little has been reported regarding the regulation of SSTR expression and biosynthesis. Recently, Slagter et al (30), using the rainbow trout model system, showed that fasting increased SSTR1 and SSTR2 expression.…”
mentioning
confidence: 99%
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