The Role of SPARC Protein Expression in the Progress of Gastric Cancer

Wang, Lifeng; Yang, Mei; Shan, Lihui; Qi, Lei; Chai, Chee‐Yin; Zhou, Qiaogen; Yao, Ke; Wang, Hongmei; Sun, Wenguang

doi:10.1007/s12253-012-9497-9

Cited by 28 publications

(31 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the present study demonstrated that SPARC mRNA expression levels were higher in gastric cancer tissues than in adjacent normal mucosa, which is in line with the results of previous studies (17,21). In addition, through univariate and multivariate analyses of potential prognostic factors using Cox proportional hazards models, high SPARC expression was revealed to be a significant predictor of poor survival in patients with stage II/III Table II.…”

Section: Discussionsupporting

confidence: 91%

“…However, previous studies have reported that high SPARC gene expression is associated with the depth of tumor invasion of stage I-IV gastric cancer (25), lymph node metastasis in esophageal cancer (26), tumor size, degree of differentiation, depth of invasion, vascular invasion, lymph-node metastases, distant metastases and TNM stage in gastric cancer (16,17).…”

Section: Multivariate Analysis --------------------------------------mentioning

confidence: 91%

“…SPARC expression is upregulated in many types of cancer (9), including pancreatic cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer and gliomas (7,(10)(11)(12)(13)(14)(15). SPARC expression is also associated with patient outcomes and clinicopathological features, including the depth of cancer cell invasion and metastasis (16,17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1

et al. 2018

View full text Add to dashboard Cite

Abstract. The standard treatment for stage II/III gastric cancer is surgical resection followed by adjuvant chemotherapy with fluoropyrimidine anticancer agents, including S-1. The protein, secreted protein, acidic and cysteine-rich (SPARC), promotes angiogenesis, and the proliferation and migration of cancer cells. The present study evaluated the significance of expression of the SPARC gene in patients with stage II/III gastric cancer who had undergone surgical resection and adjuvant chemotherapy with S-1. In the present study, reverse transcription-quantitative polymerase chain reaction was performed in order to quantify mRNA expression levels of SPARC in cancer tissues and adjacent normal mucosa obtained from 134 patients with stage II/III gastric cancer who had undergone surgical resection followed by adjuvant chemotherapy with S-1. The mRNA expression level of SPARC was significantly higher in cancer tissues than in adjacent normal mucosa (P=0.0012). Additionally, the 5-year overall survival rate was significantly poorer in patients with high SPARC gene expression than in those with low expression (P<0.0001). Furthermore, multivariate analysis indicated that high SPARC mRNA expression was a significant predictor of poorer survival in patients with stage II/III gastric cancer who had undergone surgical resection and adjuvant chemotherapy with S-1 (HR, 5.347; P<0.0001). Therefore, high expression of the SPARC gene may be a useful predictor of outcomes in patients with stage II/III gastric cancer, who have received treatment involving surgical resection and adjuvant chemotherapy with S-1.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Multivariate Analysis --------------------------------------mentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In addition, function prediction of SULF1 and CTHRC1 revealed that these proteins were mainly involved in ECM organization and constituent, transmembrane receptor protein serine/threonine kinase, FGF receptor, TGF beta receptor and Wnt receptor signaling pathway, angiogenesis, fibrinolysis, regulation of immune, and VEGF production such as SPARC, COL1A1, COL1A2, COL3A1, COL5A2, COL15A1, ASPN, VCAN, TNFSF4, FAP, POSTN, THBS2, THBS1, SULF2, SULF1, FN1, and LUM. Previous studies have reported that SPARC [37,38], COL1A1, COL1A2 and COL3A1 [39,40], POSTN [41], THBS1 [42], and SULF2 and SULF1 [29] were related to tumor stage and metastasis in GC. Though CTHRC1 had no annotated functions, it shared protein domains with collagen proteins and has been reported to be associated with metastasis in GC [21].…”

Section: Discussionmentioning

confidence: 98%

A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients

et al. 2013

View full text Add to dashboard Cite

A widely held viewpoint is that the use of multiple markers, combined in some type of algorithm, will be necessary to provide high enough discrimination between diseased cases and non-diseased. We applied stepwise logistic regression analysis to identify the best combination of the 32 biomarkers at chromosome 8q on an independent public microarray test set of 80 paired gastric samples. A combination of SULF1, INTS8, ATP6V1C1, and GPR172A was identified with a prediction accuracy of 98.0% for discriminating carcinomas from adjacent noncancerous tissues in our previous 25 paired samples. Interestingly, the overexpression of SULF1 was associated with tumor invasion and metastasis. Function prediction analysis revealed that the 4-marker panel was mainly associated with acidification of intracellular compartments. Taken together, we found a 4-gene panel that accurately discriminated gastric carcinomas from adjacent noncancerous tissues and these results had potential clinical significance in the early diagnosis and targeted treatment of gastric cancer.

show abstract

“…In GC tissues, SPARC expression disappeared in cancer cells but localized in stromal cells surrounding the cancer (13,14). However, the relationship between SPARC expression and clinicopathological factors of GCs is controversial.…”

Section: Introductionmentioning

confidence: 99%

SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells

et al. 2014

View full text Add to dashboard Cite

Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relationship between SPARC expression and clinicopathological factors of gastric cancer (GC) is controversial, and the role of SPARC in GC remains unclear. We evaluated expression of SPARC in 65 human GC tissues using immunohistochemistry (IHC). The results indicated that SPARC expression was negatively correlated with clinicopathological factors of GC. In vitro assay showed that SPARC overexpression decreased proliferation and clonogenicity by suppressing CD44 expression. In addition, SPARC overexpression inhibited VEGF induced proliferation and arrested cell cycle of GC cells by reducing the activation of VEGFR2, ERK1/2 and AKT signaling pathways. SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression. In the in vivo assay, cancer metastasis mouse models were established by tail vein injection. The results revealed that the lung metastases of SPARC-overexpressing GC cells in the mice were much fewer than those of control cells.

show abstract

The Role of SPARC Protein Expression in the Progress of Gastric Cancer

Cited by 28 publications

References 24 publications

Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1

Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1

A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients

SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells

Contact Info

Product

Resources

About