The Role of Split-course Hypofractionated Palliative Radiotherapy in Head and Neck Cancer

0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced head and neck cancers

“…This is, however, a common occurrence and similar to other studies reporting outcomes of palliative RT for patients with HNC. 3,26,27,31,32 Furthermore, it was difficult for many patients to come to follow-up appointments because of their poor performance status, distance from the cancer centre or their care being transferred to a palliative care or family physician. It is possible that in some patients, disease recurrence or worsening of symptoms occurred earlier than reported.…”

Hypofractionated palliative radiotherapy for advanced head and neck cancer: The IHF2SQ regimen

“…9 Recently, several retrospective studies have also shown a benefit and good tolerance with hypofractionated schedules in this population of patients. [16][17][18] As such, the IHF2SQ regimen is an effective and well-tolerated treatment, which can be an alternative to conventional chemoradiotherapy in patients with a limited life expectancy.…”

Proton Radiotherapy for Recurrent or Metastatic Head and Neck Cancers with Palliative Quad Shot

“…In recent years, short-course hypofractionated RT has been considered more suitable than protracted, conventional-fractionation RT because it provides equivalent symptomatic improvement, tumor response, and survival outcomes while shortening overall treatment time and minimizing effects [5–7]. Although a variety of different hypofractionation schemes have been used clinically (from 2.5–8 Gy per fraction, to a total dose of 20–48 Gy), the quad shot regimen is believed to offer the best combination of efficacy, toxicity, and patient convenience [4, 8].…”