The Role of Superoxide Dismutase in the Human Ovary and Fallopian Tube*

Tamate, Kenichi; Sengoku, Kazuo; Ishikawa, Mutsuo

doi:10.1111/j.1447-0756.1995.tb01029.x

Cited by 35 publications

(24 citation statements)

References 19 publications

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“…However, the observed lower concentration of LPO in ovulated cows in the present study may be explained by the greater level of SOD in ovulated cows, which may act as a buffer and reduce the level of LPO. In the present study, greater SOD value in ovulated cows supports the findings of Tamate et al (1995) suggesting the role of superoxide radical and SOD as a mediator for ovulation in humans. The observed increase in SOD activity in ovulated cows may due to self-protective antioxidant mechanism against the increased peroxide production required for ovulation which is thought to be associated with inflammatory like changes (Agarwal et al, 2005).…”

Section: Lpo (Nanoeq Of Hydroperoxides/ml)supporting

confidence: 95%

Changes in milk oxidative stress biomarkers in lactating dairy cows with ovulatory and an-ovulatory oestrous cycles

Talukder

Kerrisk

Gabai

et al. 2015

Animal Reproduction Science

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Section: Lpo (Nanoeq Of Hydroperoxides/ml)supporting

confidence: 95%

Changes in milk oxidative stress biomarkers in lactating dairy cows with ovulatory and an-ovulatory oestrous cycles

Talukder

Kerrisk

Gabai

et al. 2015

Animal Reproduction Science

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“…Therefore control of the ROS generation in genital tract could be an important determining factor in successful fertilization and subsequent implantation. Antioxidant enzymes such as SOD [71][72][73][74][75], GPx and catalase [71] are constantly expressed in mammalian oviduct. More recent study has revealed the ROS-scavenging role of epoxide hydrolase in the oviduct [76].…”

Section: Balance Of Intra-and Extra-cellular Reducing Status In Embrymentioning

confidence: 99%

Oxidative Stress and Redox Regulation on <i>In Vitro</i> Development of Mammalian Embryos

2012

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Abstract. Many factors affect development of mammalian preimplantation embryos in vitro. It is well known that in vitro development of bovine embryos is highly affected by culture condition including energy source, growth factors, pH or gas environment. Many efforts have been made towards the suitable environments which can successfully support embryo development in vitro. For a rapid growth and differentiation, embryo requires energy by utilizing ATP, NADPH with oxygen molecules. These energy substrates are produced from the electron transport chain in the mitochondria. In addition to energy production, reactive oxygen species (ROS) are also generated as by-product of such energy production system. ROS production is sensitively controlled by the balance of oxidizing and reducing status and affected by several antioxidant enzymes such as superoxide dismutase (SOD), Catalase, glutathione peroxidase (GPx) or low molecular weight thiols such as glutathione (GSH). Imbalance of oxidation and reduction causes production of excess ROS, which causes the developmental arrest, physical DNA damage, apoptosis induction or lipid peroxidation. Environmental oxygen condition during embryo culture also highly affects embryo development as well as intracellular redox balance. Several studies have revealed that regulation of intra-and extra-cellular reducing environment by reducing excess ROS by using antioxidants, reducing oxygen concentration are effective for improving embryo development. Also, recent studies have demonstrated the difference in gene expression affected by oxidative stress. This review briefly summarizes the effects of ROS and the role of redox balance on preimplantation embryos for improving the efficiency of in vitro production of mammalian embryos. Key words: Embryo development, Glutathione, Intracellular redox state, Reactive oxygen species (J. Reprod. Dev. 58: 1-9, 2012) H andling of oocytes and embryos in vitro is an effective technique for obtaining offspring by embryo transfer, investigating the mechanisms of early embryonic development and differentiation, gene functions by transgenic approach and research of somatic cell clones in mammals. To improve the pregnancy rates in in vitro produced (IVP) embryos, it is important to evaluate and improve the quality of embryos suitable for transfer. Therefore, increasing the number of good quality embryos as well as selection of superior quality embryos is one of the most practical and clinically useful approaches in embryo transfer of mammalian preimplantation embryos. It is well known that in vitro development of bovine embryos is highly affected by culture condition. Therefore, much effort has been made towards the effective culture methods that support embryo development in vitro. The detrimental effect of oxidative stress caused by a high oxygen concentration under culture condition on embryo development has been studied with the comparison of oxygen concentration in in vivo condition.It was found that embryo development is promoted under a low O 2 concent...

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“…The impact of follicular fluid oxidative stress on oocyte maturation, fertilization and implantation of embryo have received considerable attention for therapeutic measures of ovulation induction for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) during last few years. The study assessing the relationship of oxidative stress with oocyte quality in women who underwent ovulation induction for IVF/ICSI suggested that oxidative stress might result in poor oocyte quality [8].…”

Section: Introductionmentioning

confidence: 99%

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

Çelik

Kumbak

et al. 2012

J Assist Reprod Genet

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Objective To determine whether concentrations of oxidative stress markers of follicular fluid and serum are different in GnRH agonist protocol from GnRH antagonist protocol. Material and method This was a cross-sectional study. Eighty-four women undergoing controlled ovarian stimulation with either GnRH agonist (n039) or GnRH antagonist protocols (n045) for IVF/ICSI treatment were assigned by a physician. Blood was obtained at the time of oocyte retrieval, and follicular fluid (FF) from the mature follicles of each ovary was centrifuged and frozen until analysis. Malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), hydroxyl proline (OH-P), sodium oxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) and xanthine oxidase (XO) were assessed in the serum and follicular fluid of each participants. ResultsThe mean serum concentrations of GSH-Px, GSH and MDA were lower in the GnRH antagonist group compared to GnRH agonist group, but mean serum SOD was higher in the GnRH antagonist group. The mean follicular SOD, ADA and NO were higher in GnRH antagonist group than GnRH agonist group. The IVF/ICSI outcomes were similar in both groups. Conclusion(s) GnRH antagonist protocol is associated with increased oxidative stress. The relation of GnRH analogues with oxidative stress and its implication in follicular growth needs to be addressed in further studies.

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The Role of Superoxide Dismutase in the Human Ovary and Fallopian Tube*

Abstract: Mn-SOD and Cu, Zn-SOD have different localizations and actions in human ovaries and fallopian tubes. The superoxide radical-SOD system might play an important role in ovulation and in the luteal function of the human ovary.

Cited by 35 publications

References 19 publications

Changes in milk oxidative stress biomarkers in lactating dairy cows with ovulatory and an-ovulatory oestrous cycles

Changes in milk oxidative stress biomarkers in lactating dairy cows with ovulatory and an-ovulatory oestrous cycles

Oxidative Stress and Redox Regulation on <i>In Vitro</i> Development of Mammalian Embryos

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

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