The role of surgery for unusual sites of metastases from colorectal cancer: A review of the literature

Surgical resectability of multisite metastatic colorectal cancer: Pushing the limits while appropriately selecting patients

“…Addressing less common sites of extrahepatic metastases, Gomes et al performed a systematic review of adrenal metastases. For adrenal disease, estimates from autopsy studies are rates up to 14%.…”

“…Isolated adrenal metastases are rare, so adrenal lesions generally represent systemic dissemination. For colorectal primary disease, median overall survival for adrenalectomy was 32 months and the disease‐free interval was 3.75 years …”

“…While the presence of lymph node metastases is a poor prognostic factor, previous studies have not shown definitive evidence that the site of nodal disease, for example, portal versus aortocaval lymph nodes, confers prognosis . For adrenal metastases, the disease‐free interval of more than 6 months and complete resection suggested a good prognosis . For ovarian disease, there is an especially poor prognosis with bilateral ovarian involvement …”

“…Other uncommon metastatic sites with limited data include the adrenal glands (present in up to 14% of patients at the time of autopsy), ovaries (estimated incident between 3% and 10% among female metastatic CRC patients), and retroperitoneum (1% to 2% of metastatic CRC lesions) …”

Surgery for recurrence in retroperitoneal leiomyosarcoma: Is it all about selection?

“…The author advocate salvage resection and even encourage consideration of patients with multifocal (local) and distant metastatic disease. If the findings in the current study continue to be validated, could there be a new paradigm of resection in RP LMS, similar to that in other malignancies such as colorectal cancer, in which resection of local and distant recurrences (liver, lung) are routine in select patients?…”