The role of targeted therapy for gastrointestinal tumors

Rolfo, Christian; Bronte, Giuseppe; Sortino, Giuseppe; Papadimitriou, Konstantinos; Passiglia, Francesco; Fiorentino, Eugenio; Marogy, Ghada; Russo, Antonio; Peeters, Marc

doi:10.1586/17474124.2014.922870

Cited by 29 publications

(17 citation statements)

References 78 publications

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“…Zusätzlich haben molekulare zielgerichtete Therapien durch die Entwicklung monoklonaler Antikörper gegen den epidermalen Wachstumsfaktorrezeptor (EGFR) oder auch den vaskulären endothelialen Wachstumsfaktor (VEGF) erheblich an Bedeutung gewonnen [40].…”

Section: Prädiktive Biomarkerunclassified

Molekulare Pathologie des kolorektalen Karzinoms

2015

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Section: Prädiktive Biomarkerunclassified

Molekulare Pathologie des kolorektalen Karzinoms

2015

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“…Regorafenib also inhibits the oncogenic RTKs, KIT and RET, along with the intracellular signaling kinases c-RAF/RAF-1, BRAF and its V600E mutant form [66]. Regorafenib was approved for advanced GIST that cannot be surgically removed and no longer responds to imatinib and sunitinib, and for previously treated metastatic colorectal cancer [67][68][69].…”

Section: Regorafenibmentioning

confidence: 99%

Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy

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et al. 2014

Expert Opinion on Drug Safety

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“…5 Additionally, the presence of metastasis in the lymph nodes is a frequent event in this type of neoplasia and is considered an important prognostic marker, because it may contribute to the high rates of recurrence and/or GC mortality. 6 However, the mechanisms of GC cells' migration, invasion and metastasis have not been fully understood.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of EGFR inhibits growth and invasion of gastric cancer cells

2014

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The epidermal growth factor receptor (EGFR) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of EGFR in gastric cancer (GC) is still elusive. In this study, we aimed to investigate the expression and molecular mechanisms of EGFR in GC cells. Forty cases of GC and the corresponding adjacent non-cancerous tissues (ANCT) were collected, and the expression of EGFR was assessed using immunohistochemistry in biopsy samples. Furthermore, EGFR signaling was blocked by constructed recombinant small hairpin RNA lentiviral vector (Lv-shRAGE) used to transfect into human GC SGC-7901 cells. The expression of AKT, proliferating cell nuclear antigen (PCNA) and matrix metallopeptidase-9 (MMP-9) was detected by real-time PCR and western blotting assays. Cell proliferative activities and invasive capability were, respectively, determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and Transwell assays. Cell apoptosis and cycle distribution were analyzed by flow cytometry. EGFR was found highly expressed in cancer tissues compared with the ANCT and correlated with lymph node metastases. Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PCNA and MMP-9 and induced cell apoptosis and cycle arrest. Upregulation of EGFR expression is associated with lymph node metastases of GC, and blockade of EGFR signaling suppresses growth and invasion of GC cells through AKT pathway, suggesting that EGFR may represent a potential therapeutic target for this aggressive malignancy.

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The role of targeted therapy for gastrointestinal tumors

Cited by 29 publications

References 78 publications

Molekulare Pathologie des kolorektalen Karzinoms

Molekulare Pathologie des kolorektalen Karzinoms

Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy

Knockdown of EGFR inhibits growth and invasion of gastric cancer cells

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