The Role of Temperature in Transmission of Zoonotic Arboviruses

Ciota, Alexander T.; Keyel, Alexander C.

doi:10.3390/v11111013

Cited by 63 publications

(76 citation statements)

References 266 publications

(380 reference statements)

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“…Firstly, the rearing temperature, which is an extrinsic factor that affects direct and indirectly the Ae. albopictus susceptibility to arbovirus [23,40,41]. The environmental factors in which mosquitoes were reared, may have played a crucial role for ZIKV transmission of Spanish Ae.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Zika virus horizontal and vertical transmission in Aedes albopictus from Spain but not infectious virus in saliva of the progeny

Núñez

Talavera

Birnberg

et al. 2020

Emerging Microbes & Infections

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Aedes albopictus mosquitoes have been experimentally demonstrated to be a competent vector for Zika virus (ZIKV) in different countries, but there are still some gaps related to the importance of Ae. albopictus in ZIKV transmission. Recent studies on Spanish Ae. albopictus populations showed controversial results for ZIKV transmission and no studies have been performed yet to detect infectious ZIKV in saliva of progeny of infected female mosquitoes. Herein, the horizontal transmission (HT) and vertical transmission (VT) of ZIKV in field-collected Ae. albopictus mosquitoes from Spain were evaluated for ZIKV strains (African I and Asian lineages) to better estimate the risk of ZIKV transmission by Ae. albopictus. The two field-collected Ae. albopictus populations assayed were infected by all tested ZIKV strains, however differences in terms of vector competence were detected depending on strain-population combination. Moreover, a higher susceptibility to the African I lineage strain than to the Asian lineage strain was observed in both mosquito populations. On the other hand, VT was demonstrated for both ZIKV lineages, detecting the virus in both males and females of the progeny of infected females, although importantly ZIKV dissemination and transmission were not detected in the infected females from the offspring. The results of the present study demonstrate that Spanish Ae. albopictus populations could sustain virus transmission in case of ZIKV introduction, but VT would play a poor role in the ZIKV epidemiology. Overall, our results provide helpful information to health authorities to establish efficient surveillance and vector control programmes for ZIKV.

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Section: Discussionmentioning

confidence: 99%

Evidence of Zika virus horizontal and vertical transmission in Aedes albopictus from Spain but not infectious virus in saliva of the progeny

Núñez

Talavera

Birnberg

et al. 2020

Emerging Microbes & Infections

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“…The storage conditions may not be optimal, and hence some mosquitoes may therefore perish before they are collected. Furthermore, DENV infectivity is temperature-related: higher temperatures hasten the spread of DENV within the mosquito [ 32 ]. Two studies have reported the successful detection of DENV within infected mosquitoes using NS1 Ag or qPCR after multiple freeze–thaw cycles and/or drying [ 9 , 13 ], even for mosquitoes that had been desiccated for 30 days.…”

Section: Discussionmentioning

confidence: 99%

Releasing Intracellular NS1 from Mosquito Cells for the Detection of Dengue Virus-Infected Mosquitoes

Cheng

Liu

et al. 2020

Viruses

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Dengue virus (DENV), the pathogen that causes dengue fever, is mainly transmitted by Aedes aegypti. Surveillance of infected mosquitoes is a major component of integrated mosquito control methods for reducing the risk of vector-born disease outbreaks. However, a specialized rapid test for DENV detection in mosquitoes is not currently available. Utilizing immunoblotting, we found that the secretion of NS1 from both a DENV-infected mosquito cell line and mosquito bodies was below the detection threshold. However, when Triton X-100 was used to lyse infected mosquitoes, intracellular NS1 was released, and could then be effectively detected by the NS1 rapid test. The distribution of DENV NS1 in intrathoracically infected mosquitoes was different from that of orally infected mosquitoes. Next, we performed sensitivity tests by bisecting mosquitoes longitudinally; one half of each mosquito was subjected to the NS1 rapid test while the other half was used for qPCR confirmation. This modified test had a sensitivity of nearly 90% from five days post-infection onwards, while DENV had escaped from the midgut barrier. This adapted test offers a valuable, easy-to-use tool for mosquito surveillance, which is a crucial component of DENV disease control.

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“…A key principle of thermal biology is that the effects of temperature on mosquito-borne disease transmission are unimodal with lower and upper limits. Starting at zero for a lower temperature limit, their value increase with the temperature until a maximum, then it starts to decrease until an upper temperature limit is reached [23]. Such behavior can be well approximated by a Gaussian distribution.…”

Section: A Influence Of Environmental Factors On Vector-borne Diseasesmentioning

confidence: 94%

Impact of Seasonal Conditions on Vector-Borne Epidemiological Dynamics

2020

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Vector-borne diseases such as malaria, dengue fever, West Nile virus, and so forth are some of the most prominent threats to human health. They are transmitted to the human population by infected insects or by direct transmission between humans. The epidemic process relies on suitable environmental and climatic conditions. Indeed, climatic factors affect the development of pathogens in vectors as well as the population dynamics of the vectors impacting significantly the incidence of disease in the human population. While the influence of the climatic conditions on Vector-borne diseases is well-documented, there is a strong need to design more realistic epidemiological models incorporating environmental features that show a close relationship with the epidemic process observed in the human population. Indeed, classical models concentrate either on the climatic influence on the vector population dynamics or on the connectivity patterns of the host population, loosing the full picture of the epidemic process dynamics. Inspired by real data of infectious diseases, a Seasonal Susceptible-Infected-Recovered (Seasonal SIR) epidemiological model is developed and analyzed. The proposed model incorporates the influence of the temperature variations together with the heterogeneous structure of the human interaction network on the spreading process of vector-borne diseases. Simulations are performed in order to get a better understanding of the climate variations and of the heterogeneous nature of the contact network on the transmission dynamics. Results show that failing to incorporate these features on the model can lead to a poor estimation of the maximum fraction of infected individuals in the host population. Furthermore there is a serious influence on the time needed to reach this maximum. The Seasonal SIR model proves to finely model the dynamics of outbreaks observed in real-world situations. It provides a basis for more effective predictions of disease outbreaks that can be used in order to implement appropriate control measures to contain epidemics. INDEX TERMS Vector-borne diseases, epidemics, heterogeneous contact network, climate variations, dynamics on networks, SIR model, epidemiological models.

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The Role of Temperature in Transmission of Zoonotic Arboviruses

Cited by 63 publications

References 266 publications

Evidence of Zika virus horizontal and vertical transmission in Aedes albopictus from Spain but not infectious virus in saliva of the progeny

Evidence of Zika virus horizontal and vertical transmission in Aedes albopictus from Spain but not infectious virus in saliva of the progeny

Releasing Intracellular NS1 from Mosquito Cells for the Detection of Dengue Virus-Infected Mosquitoes

Impact of Seasonal Conditions on Vector-Borne Epidemiological Dynamics

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