The role of Th17 cells in psoriasis

Li, Binbin; Huang, Liangliang; Lv, Peng; Li, Xiang; Liu, Ge; Chen, Yan; Wang, Ziyu; Qian, Xiaoxian; Shen, Yixiao; Li, Yunman; Fang, Weirong

doi:10.1007/s12026-020-09149-1

Cited by 88 publications

(74 citation statements)

References 165 publications

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“…However, serum analysis from psoriatic individuals has indicated antibodies against Malassezia and its antigens (Squiquera et al, 1994;Gemmer et al, 2002;Jagielski et al, 2014). In Psoriasis, interleukin 23 (IL-23)/Th17 immune axis has been identified as a major pathway (Blauvelt, 2008;Girolomoni et al, 2017;Li et al, 2020). Malassezia can also induce Th1-related cytokines in peripheral blood mononuclear cells in vitro (Kanda et al, 2002;Valli et al, 2010) and induce keratinocyte proliferation and proinflammatory cytokine production which could potentially enhance inflammation (Baroni et al, 2004).…”

Section: Malassezia In Atopic Dermatitis: Pathogenesis or Mutualism?mentioning

confidence: 99%

Cutaneous Malassezia: Commensal, Pathogen, or Protector?

Chandra

Ramasamy

Dawson

et al. 2021

Front. Cell. Infect. Microbiol.

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The skin microbial community is a multifunctional ecosystem aiding prevention of infections from transient pathogens, maintenance of host immune homeostasis, and skin health. A better understanding of the complex milieu of microbe-microbe and host-microbe interactions will be required to define the ecosystem’s optimal function and enable rational design of microbiome targeted interventions. Malassezia, a fungal genus currently comprising 18 species and numerous functionally distinct strains, are lipid-dependent basidiomycetous yeasts and integral components of the skin microbiome. The high proportion of Malassezia in the skin microbiome makes understanding their role in healthy and diseased skin crucial to development of functional skin health knowledge and understanding of normal, healthy skin homeostasis. Over the last decade, new tools for Malassezia culture, detection, and genetic manipulation have revealed not only the ubiquity of Malassezia on skin but new pathogenic roles in seborrheic dermatitis, psoriasis, Crohn’s disease, and pancreatic ductal carcinoma. Application of these tools continues to peel back the layers of Malassezia/skin interactions, including clear examples of pathogenicity, commensalism, and potential protective or beneficial activities creating mutualism. Our increased understanding of host- and microbe-specific interactions should lead to identification of key factors that maintain skin in a state of healthy mutualism or, in turn, initiate pathogenic changes. These approaches are leading toward development of new therapeutic targets and treatment options. This review discusses recent developments that have expanded our understanding of Malassezia’s role in the skin microbiome, with a focus on its multiple roles in health and disease as commensal, pathogen, and protector.

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Section: Malassezia In Atopic Dermatitis: Pathogenesis or Mutualism?mentioning

confidence: 99%

Cutaneous Malassezia: Commensal, Pathogen, or Protector?

Chandra

Ramasamy

Dawson

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Patients on systemic treatments have more severe psoriasis, with increased initial PASI scores and recalcitrance to exclusive topical treatments. It is known that Th17 inflammatory axis activation has a positive correlation with the severity of psoriasis [ 9 ]. This fact explains the higher detection of IL-17A in G1, G2 and G4, which was not seen in the topical treatment group (G3) with mild psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…This analysis represents the first step in the comprehension of innate and adaptative immune responses against viral infections in a population with an imbalanced immune system. Psoriasis, like many other inflammatory and autoimmune diseases—such as multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease—presents a deviation of T lymphocytes to a Th17 pattern [ 9 ]. Although the IL-23/Th-17 pathway leads to the production of anti-viral cytokines in the skin of psoriatic patients (type III IFN) [ 2 , 7 ], it is still unknown whether these molecules play an important role in the prevention of systemic infections, such as COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…Plasmacytoid dendritic cell activation—mediated by human cathelicidin antimicrobial peptide (CAMP), known as LL-37, and Toll-like receptor 9 (TLR9)—complexed to self-nucleotides exerts a key role in the disease, leading to production of type I IFN (IFN-α and IFN-β) as well as Th1 and Th17 cells interleukins (IFN-γ and IL-17, respectively) and proinflammatory cytokines (TNF-α, IL-12, IL-23, IL-6 and IL-1β). Other pro-inflammatory cytokines—such as IL-23, which is produced by dermal leucocytes from a myeloid lineage —induce the proliferation and differentiation of Th17 lymphocytes and perpetuate the inflammatory cascade in psoriasis [ 1 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Inflammatory Immune Dysfunction in Psoriasis Patients at Risk for COVID-19

et al. 2021

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Psoriasis is an immune-mediated dermatosis usually associated with comorbidities. Treatment varies from topicals to systemic drugs and data on susceptibility to viral infections in psoriatic patients are scarce. The objectives of this study were to analyze psoriatic patients on different therapies who were at risk for COVID-19 for seroprevalence of SARS-COV-2, pro-inflammatory cytokine profile, comorbidities and outcomes in order to unveil the immunological mechanisms involved in the anti-viral response in patients with psoriasis. Seventy-five patients with psoriasis were divided according to treatment: immunobiologics, methotrexate, topicals and acitretin. Twenty healthy controls were included. Plasma samples were collected for: IgG SARS-COV-2 (ELISA); IL-27, IL-29 and IL-18 (ELISA); and IL-1β, IL-17A, IL-6 and TNF (cytometric array). Seropositivity for SARS-COV-2 was detected in 24 out of 75 psoriasis patients and did not relate to COVID-19 symptoms and/or hospitalization, despite associated comorbidities. Psoriasis patients who were asymptomatic for SARS-COV-2 exhibited immune imbalance with high levels of IL-18, IL-17A and IL-6, and low levels of IL-27 compared to healthy controls. Psoriasis groups showed significant increased cytokine levels only in the group with immunobiologics. Despite immune deviations and lower IL-27, which has a potential antiviral impact, psoriatic patients did not exhibit complications related to COVID-19. An understanding of this kind of proinflammatory profile of psoriatic patients and of the lack of severe outcomes for COVID-19 is essential to establish novel therapeutic approaches and preventive measures, including with regard to the concomitance of viral infections.

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“…Inflammatory diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease are sometimes exacerbated by lymphocytes [14][15][16][17]. IL-17-producing cells are related to inflammation induced by the synergistic effect of certain inflammatory cytokines, including IL-23 and TNF-α, and antigen-presenting cells, following the upregulation of transcription factor RORγt [18]. In the development of IL-17-producing CD4 + cells, TGF-β and IL-6 are required for the differentiation from naïve T cells [19].…”

Section: Th17 Cells and Antimicrobial Action Against Fungimentioning

confidence: 99%

The Role of IL-17-Producing Cells in Cutaneous Fungal Infections

Sawada

Setoyama

Sakuragi

et al. 2021

IJMS

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The skin is the outermost layer of the body and is exposed to many environmental stimuli, which cause various inflammatory immune responses in the skin. Among them, fungi are common microorganisms that colonize the skin and cause cutaneous fungal diseases such as candidiasis and dermatophytosis. The skin exerts inflammatory responses to eliminate these fungi through the cooperation of skin-component immune cells. IL-17 producing cells are representative immune cells that play a vital role in anti-fungal action in the skin by producing antimicrobial peptides and facilitating neutrophil infiltration. However, the actual impact of IL-17-producing cells in cutaneous fungal infections remains unclear. In this review, we focused on the role of IL-17-producing cells in a series of cutaneous fungal infections, the characteristics of skin infectious fungi, and the recognition of cell components that drive cutaneous immune cells.

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The role of Th17 cells in psoriasis

Cited by 88 publications

References 165 publications

Cutaneous Malassezia: Commensal, Pathogen, or Protector?

Cutaneous Malassezia: Commensal, Pathogen, or Protector?

Impact of Inflammatory Immune Dysfunction in Psoriasis Patients at Risk for COVID-19

The Role of IL-17-Producing Cells in Cutaneous Fungal Infections

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