2004
DOI: 10.1016/j.ejphar.2004.04.029
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The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig

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Cited by 33 publications
(15 citation statements)
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“…In the same way as 5‐HT, the activation of 5‐HT 1D receptors caused a dose‐ and frequency‐dependent inhibition of mesenteric noradrenergic outflow, confirming that the 5‐HT behaviour is mainly due to the activation of this receptor subtype. We corroborate that the pharmacological profile of the sympatholytic receptors involved is the 5‐HT 1D subtype since (i) L‐694,247 is a potent agonist at 5‐HT 1D receptors, (ii) this sympathoinhibition was completely blocked by the selective 5‐HT 1D antagonist, LY310762, and (iii) this antagonist abolished the 5‐HT‐evoked sympatholytic effect (see Figure ).…”
Section: Discussionsupporting
confidence: 81%
“…In the same way as 5‐HT, the activation of 5‐HT 1D receptors caused a dose‐ and frequency‐dependent inhibition of mesenteric noradrenergic outflow, confirming that the 5‐HT behaviour is mainly due to the activation of this receptor subtype. We corroborate that the pharmacological profile of the sympatholytic receptors involved is the 5‐HT 1D subtype since (i) L‐694,247 is a potent agonist at 5‐HT 1D receptors, (ii) this sympathoinhibition was completely blocked by the selective 5‐HT 1D antagonist, LY310762, and (iii) this antagonist abolished the 5‐HT‐evoked sympatholytic effect (see Figure ).…”
Section: Discussionsupporting
confidence: 81%
“…Neither GR55562 nor SB224289 had an effect on either the EPSC amplitude or the PPR (Figure 4Bb and Table S1), indicating that there is little tonic activation of presynaptic 5‐HT 1B receptors. In contrast, CP93129 (1 µM) still decreased EPSCs in the presence of 10 µM LY310762, a selective 5‐HT 1D receptor antagonist (IC 50 = 31 nM, Pullar et al ., 2004) (61.3 ± 8.5% of the LY310762 condition, n = 5, P < 0.05; Figure 4C and D), suggesting that 5‐HT 1B receptors are responsible for the CP93129‐induced inhibition of glutamate release.…”
Section: Resultsmentioning
confidence: 99%
“…Indeed, this suggestion is strengthened by the fact that L-694,247-induced inhibition was completely blocked by LY310762, since i) it has a very high affinity for prejunctional 5-HT 1D receptors [25] and (ii) it was able to completely block the 5-CT-induced inhibition (see Fig. 6).…”
Section: The Role Of Prejunctional Receptors In the Inhibition Of Thementioning
confidence: 87%