The role of the A54T polymorphism of the intestinal fatty acid binding protein for lipid levels, insulin sensitivity and carotid atherosclerosis

Renner, Wilfried; Pressl, Helga; Paulweber, Bernhard; Malaimare, L.; Iglseder, Bernhard; Wascher, Thomas C.

doi:10.1016/j.atherosclerosis.2003.11.018

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Abbreviations see Tables 1 and 2. chemical characteristics of MS (Yamada et al 1997;Levy et al 2001). On the contrary, large cross-sectional population studies could not prove any linkage of FABP-2 Ala54Thr polymorphism with parameters of MS (Ishii et al 2001;Renner et al 2004). In the Framingham Heart Study, the risk for coronary heart disease was raised by the presence of ε 4 allele, as well as ε 2 allele (Lahoz et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Žák

Tvrzická

Vecka

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Metabolic syndrome (MS) is defined by the clustering of several components (MSC), which include abdominal fat accumulation, impaired glucose homeostasis, hypertriglyceridemia, lowered high-density lipoprotein cholesterol, increased blood pressure, and hyperuricemia. Metabolic syndrome is also accompanied by increased oxidative stress and inflammation as well as by altered composition of esterified fatty acids (FA). Therefore, we have investigated 210 men (categorized into six groups with increasing number of MSC) to find trends in the extent of oxidative stress, FA pattern and frequency of pathological alleles of the selected candidate genes for lipid metabolism. Increasing number of MSC was connected with the raised serum glucose and insulin, increased concentrations of conjugated dienes in low-density lipoprotein (all p < 0.0001), and high frequency of e2 and e4 alleles of the apolipoprotein E gene ( p < 0.005). However, the last significance was lost after the adjustment for age. The incidence of 54Thr allele for intestinal isoform of the fatty acid-binding protein (FABP-2) gene was comparable in all groups. The most important findings were the raised content of saturated FA and the increased activities of Δ 9 and Δ 6 desaturases (all p < 0.0001), and the decreased content of polyunsaturated FA n-6 family and the decreased activity of Δ 5 desaturase (both p < 0.001) in connection with increasing number of MSC. In conclusion, the severity of MS is connected with the progression of oxidative stress and the unfavorable changes in the FA composition. These changes are independent of the studied gene polymorphisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Žák

Tvrzická

Vecka

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Publicaciones recientes han examinado el rol del polimorfismo Ala54Thr FABP2 sobre algunos parámetros del síndrome metabólico, encontrándose una modesta alza en la presión arterial diastólica y en el colesterol LDL para los homocigotos Thr54Thr; también este genotipo se asoció a un leve incremento máximo del grosor de la capa íntima media de las carótidas en hombres 35,36 .…”

Section: Polimorfismo De Fabp2 Y Problemas Metabólicosunclassified

Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia

et al. 2006

Rev. méd. Chile

View full text Add to dashboard Cite

The genetic components of insulin-resistance, diabetes and obesity have been largely studied. These conditions are determined by multiple polygenic and environmental factors. Certain candidate genes, that have common functional variants in the general population, may be important determinants of inter-individual differences in the response to dietary changes. This review focuses in one of the major candidate genes, the gene encoding for the FABP2, an intracellular protein expressed only in the intestine, involved in the absorption and intracellular transport of dietary long chain fatty acids. Carriers of the Thr54 allele in FABP2 have a 2-fold greater affinity for long chain fatty acids than Ala54 carriers. The increased flux of dietary fatty acids (FA) into the circulation, among carriers of FABP2 Ala54Thr, supports a role of the polymorphism of this allele in the etiology of metabolic disorders. The frequencies of the polymorphism in different populations fluctuate between 18% and 40%. FABP2 Ala54Thr variant has been associated with an increased fasting insulin concentration, fasting fatty acid oxidation and reduced glucose uptake. This evidence, although not conclusive, sustains an association between FABP-2 genotype and metabolic abnormalities.

show abstract

The role of the A54T polymorphism of the intestinal fatty acid binding protein for lipid levels, insulin sensitivity and carotid atherosclerosis

Cited by 2 publications

References 14 publications

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia

Contact Info

Product

Resources

About