The Role of the Adenoids in Pediatric Chronic Rhinosinusitis

Belcher, Ryan; Virgin, Frank W.

doi:10.3390/medsci7020035

Cited by 30 publications

(33 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Children with recurrent acute OM were found to have large parts of their adenoid mucosa covered with polymicrobial biofilms containing middle ear pathogens [177]. Similar findings have been reported in children with CRS [178]. On the other hand, in vitro experiments showed that when epithelial cells were covered by S. oralis and S. salivarius biofilms, the cells were protected from GAS adherence, internalization, and cytotoxic effects [179].…”

Section: Pharyngitis and Laryngitissupporting

confidence: 57%

Bacterial Biofilm and its Role in the Pathogenesis of Disease

et al. 2020

View full text Add to dashboard Cite

Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. In most cases reviewed, the biofilms were identified through various imaging technics, in addition to other study approaches. The current knowledge on how biofilm may contribute to the pathogenesis of disease indicates a number of different mechanisms. This spans from biofilm being a mere reservoir of pathogenic bacteria, to playing a more active role, e.g., by contributing to inflammation. Observations also indicate that biofilm does not exclusively occur extracellularly, but may also be formed inside living cells. Furthermore, the presence of biofilm may contribute to development of cancer. In conclusion, this review shows that biofilm is part of many, probably most chronic infections. This is important knowledge for development of effective treatment strategies for such infections.

show abstract

Section: Pharyngitis and Laryngitissupporting

confidence: 57%

Bacterial Biofilm and its Role in the Pathogenesis of Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The prevalence of CRS in paediatric patients is now estimated to be up to 4% (109) .Both passive and active cigarette smoking are associated with chronic rhinitis and rhinosinusitis in children (110) though a clear and definitive causal relationship between allergic rhinitis and CRS has not been established (111) . Evidence suggests that the adenoids may act as a reservoir for pathogenic bacteria, rather than a source of obstruction (112,113) whilst the relationship between GORD and CRS in children remains controversial (114) . A large database study suggests a significant familial risk associated with paediatric CRS (115) but studies on monozygotic twins have not shown that both siblings always develop polyps, indicating that environmental factors are as likely as genetic ones to influence the occurrence of nasal polyps.…”

Section: Fessmentioning

confidence: 99%

Executive Summary of EPOS 2020 Including Integrated Care Pathways

Fokkens

Lund

Hopkins

et al. 2020

Rhin

360

254

View full text Add to dashboard Cite

The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 (1-3). The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence

show abstract

“…Гипертрофия глоточной миндалины наблюдается у 34-70% детей разных возрастных групп и 2,5% взрослых [47][48][49]. Обзоры литературы по ключевым словам «аденоиды» и «хронический синусит» показали, что гипертрофия глоточной миндалины способствует формированию хронического риносинусита как причина назальной обструкции, препятствующая нормальной аэрации ОНП, а также как бактериальный резервуар, содержащий биопленки [47,48]. Эти факторы нарушают мукоцилиарный клиренс ОНП.…”

Section: цель работыunclassified

Effect of nasal cavity and nasopharynx architectonic disorders on the paranasal sinus development and sinusitis

Subbotina¹,

Kokhanov²

2020

View full text Add to dashboard Cite

The structure of the paranasal sinuses (PNS) is characterized by pronounced variability and largely depends on the state of the intranasal architectonics, the violation of which may be a predisposing factor for the development of sinusitis. Leading among the disturbances in the architectonics of the nasal cavity and nasopharynx are the nasal septum deviation (NSD), concha bullosa (CB), hypertrophy of the inferior turbinates and pharyngeal tonsil. This review presents an analysis of modern data on the influence of the architectonics of the nasal cavity and nasopharynx on the development of PNS and the formation of inflammatory processes in them. Sources of information - databases Medline, Pubmed, Cochrane, E-library from 2004 to 2019. The search was carried out by keywords. Criteria for inclusion of articles in the review: assessment of multispiral computed tomography of SNP of patients in axial and coronary projections, presence of a control group, sample size of more than 50 people. In the presented review, it is noted that types 3 and 5 of DNP according to the classification of R. Mladina, along with contralateral CB and adenoids, can be predictors of the development of sinusitis. Information about the side of sinusitis formation in relation to the direction of the deformity of the nasal septum, about the effect of other violations of the architectonics of the nasal cavity on sinusitis and the size of the SNP remains controversial. The reasons for the contradictions are the use of different classifications of DNP, the underestimation of the complexes of anatomical anomalies and the mechanisms of aerodynamics of the sinuses, which determine the greater dependence of the volume and ventilation of the sinuses on expiration than on inspiration. Taking these positions into account, the question of the influence of the architectonics of the nasal cavity on the development of the paranasal sinuses and the formation of the inflammatory process in them requires further study.

show abstract

The Role of the Adenoids in Pediatric Chronic Rhinosinusitis

Cited by 30 publications

References 31 publications

Bacterial Biofilm and its Role in the Pathogenesis of Disease

Bacterial Biofilm and its Role in the Pathogenesis of Disease

Executive Summary of EPOS 2020 Including Integrated Care Pathways

Effect of nasal cavity and nasopharynx architectonic disorders on the paranasal sinus development and sinusitis

Contact Info

Product

Resources

About