The Role of the Cerebellum in Tremor – Evidence from Neuroimaging

Berg, Kevin R. E. van den; Helmich, Rick C.

doi:10.5334/tohm.660

Cited by 46 publications

(22 citation statements)

References 99 publications

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“…In contrast, in TDPD, the cerebellum may be a modulator which contributes to tremor oscillations by influencing the thalamocortical circuit. ( van den Berg and Helmich, 2021 ) The role of the cerebellum in tremor is further underscored by the ALE findings of this study, namely implicating the cerebellum lobule IV-V, a region to which sensorimotor regions project and which has been shown to be active during a finger-tapping task. ( Stoodley et al, 2012 ) Notably, in a study investigating FC of the dentate nucleus, connectivity with the cerebellum and caudate was found to be increased and decreased, respectively, in TDPD patients.…”

Section: Discussionmentioning

confidence: 63%

Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI

Marapin

Horn

Stouwe

et al. 2023

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 63%

Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI

Marapin

Horn

Stouwe

et al. 2023

NeuroImage: Clinical

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“…Several recent studies have shown that the cerebellum is functionally connected to the cerebral cortex through feedforward and feedback pathways [ 29 ]. In a study of both animals and humans, the cerebellum was shown to play a critical role in tremor generation [ 30 ]. In addition, physiological tremors may also occur even in healthy individuals via abnormal proprioception feedback from the limbs (the peripheral system) to the cerebral cortex (the central nervous system) during a specific stance or performance of movements against gravity or retention of mechanical force [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between physiological tremor and cognitive function in physically active older women

et al. 2022

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[Purpose] This study aimed to compare the physiological tremor, grip strength, and cognitive function of sedentary and physically active older adults.[Methods] Twenty-four older adults aged ≥65 years participated in this study and were divided into the sedentary (76.5±4.4 years, n=12) and physically active (73.5±3.3 years, n=12) groups. Each group completed the Mini-Mental State Examination (MMSE) for cognitive function assessment. Physiological tremor was measured using an accelerometer for both hands at rest and the left/right hand with a 1,000 g dumbbell on the palm in neutral positions and the elbow flexed at 90°. Physical fitness was measured by grip strength and completion of the Short Physical Performance Battery (SPPB) and the 6-min walk test.[Results] The physically active group showed a significantly lower level of physiological tremor in both hands at rest and the left/right hand with a 1,000 g dumbbell on the palm (P<0.05) than that in the sedentary group. For cognitive function, the physically active group showed significantly higher scores than those in the sedentary group (P<0.001). No significant correlation was found between cognitive function and left/right grip strength (left: r = 0.117, P = 0.585; right: r = 0.230, P = 0.279), physiological tremor in both hands at rest (left: r = -0.524, P < 0.001; right: r = -0.508, P < 0.05), and the left/right hand with a 1,000 g dumbbell on the palm (left: r = -0.505, P < 0.05; right: r = -0.458, P < 0.05).[Conclusion] Physiological tremor of the hands has the potential to be a useful predictor of cognitive function in older adults.

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“…Other tremor disorders include orthostatic tremor, which manifests as leg tremor during standing, and tremor associated with degenerative causes such as Wilson's disease. Multiple lines of neuroimaging studies have also demonstrated that the cerebellum is a critical brain region in ET and parkinsonian tremor [13][14][15][16][17]. In the post-mortem pathological examination, ET brains have some cerebellar degenerative changes, including modest Purkinje cell loss [18,19].…”

Section: Cerebellar Involvement In Ataxia Tremor and Dystoniamentioning

confidence: 99%

Physiological Recordings of the Cerebellum in Movement Disorders

et al. 2022

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The cerebellum plays an important role in movement disorders, specifically in symptoms of ataxia, tremor, and dystonia. Understanding the physiological signals of the cerebellum contributes to insights into the pathophysiology of these movement disorders and holds promise in advancing therapeutic development. Non-invasive techniques such as electroencephalogram and magnetoencephalogram can record neural signals with high temporal resolution at the millisecond level, which is uniquely suitable to interrogate cerebellar physiology. These techniques have recently been implemented to study cerebellar physiology in healthy subjects as well as individuals with movement disorders. In the present review, we focus on the current understanding of cerebellar physiology using these techniques to study movement disorders.

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The Role of the Cerebellum in Tremor – Evidence from Neuroimaging

Cited by 46 publications

References 99 publications

Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI

Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI

Relationship between physiological tremor and cognitive function in physically active older women

Physiological Recordings of the Cerebellum in Movement Disorders

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