The role of the cytoskeleton during neuronal polarization

Witte, Harald; Bradke, Frank

doi:10.1016/j.conb.2008.09.019

Cited by 193 publications

(164 citation statements)

References 55 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…The stabilization of microtubules is crucial for the axon specification in vitro (Bradke and Dotti, 1999;Witte and Bradke, 2008). The stabilization of microtubules is regulated by MAPs such as Tau and CRMP2.…”

Section: Cytoskeletal Organizationmentioning

confidence: 99%

“…The small GTPase Cdc42 is a key regulator of multiple aspects of neuronal development, including filopodial extension in growth cones (Schwamborn and Puschel, 2004;Arimura and Kaibuchi, 2007;Witte and Bradke, 2008). Conditional knockout of Cdc42 in the cortex and hippocampus leads to reduced embryonic cortex size and results in lethality at birth with impairment in axon formation (Garvalov et al, 2007).…”

Section: Rho Family Proteins In Neuronal Polaritymentioning

confidence: 99%

See 1 more Smart Citation

Neuronal polarization

et al. 2015

View full text Add to dashboard Cite

Neurons are highly polarized cells with structurally and functionally distinct processes called axons and dendrites. This polarization underlies the directional flow of information in the central nervous system, so the establishment and maintenance of neuronal polarization is crucial for correct development and function. Great progress in our understanding of how neurons establish their polarity has been made through the use of cultured hippocampal neurons, while recent technological advances have enabled in vivo analysis of axon specification and elongation. This short review and accompanying poster highlight recent advances in this fascinating field, with an emphasis on the signaling mechanisms underlying axon and dendrite specification in vitro and in vivo.

show abstract

Section: Cytoskeletal Organizationmentioning

confidence: 99%

Section: Rho Family Proteins In Neuronal Polaritymentioning

confidence: 99%

Neuronal polarization

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The induction and elaboration of axonal and dendritic morphologies are fundamental aspects of neuronal network formation and information processing in the CNS. Actin filament formation at defined sites at the cell cortex is a source for the forces required for the induction of the different protrusive structures formed by neurons, such as neurites, branches within the neuritic arbor, and dendritic spines (Cingolani and Goda, 2008;Witte and Bradke, 2008). Actin polymerization, which also plays an important role in growth cone and spine dynamics and plasticity, depends on the help of specialized actin nucleation promoting factors, such as the Arp2/3 complex, which is activated by members of the Wiskott-Aldrich syndrome protein (WASP) family.…”

Section: Introductionmentioning

confidence: 99%

F-BAR Proteins of the Syndapin Family Shape the Plasma Membrane and Are Crucial for Neuromorphogenesis

Dharmalingam¹,

Haeckel²,

Pinyol³

et al. 2009

J. Neurosci.

111

134

View full text Add to dashboard Cite

“…In particular, microtubules are the main determinants of neuronal polarity and regulation of microtubule dynamics includes tubulin posttranslational modifications [40] and phosphorylation of microtubule-associated proteins (MAPs), whose binding to microtubules is essential for neurite formation [41]. As an example, activated GSK-3β leads to increased phosphorylation of some MAPs, destabilizing microtubules with consequence for neurite stabilization [42]. Therefore, the neurite destabilization could derive from both NFs and microtubules disruption.…”

Section: +mentioning

confidence: 99%

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Zamoner¹,

Pessoa-Pureur²

2017

Cytoskeleton - Structure, Dynamics, Function and Disease

View full text Add to dashboard Cite

In this chapter, we deal with the current knowledge and important results on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca 2+mediated mechanisms in developmental rat brain. We focus on the misregulation of the phosphorylating system associated with intermediate filament proteins of neural cells and its relevance to cell and tissue dysfunction. Taking into account our findings, we propose that intermediate-filament proteins are dynamic structures whose regulation is crucial for proper neural cell function. Given their relevance, they must be regulated in response to extracellular and intracellular signals. The complexity and connection between signaling pathways regulating intermediate-filament dynamics remain obscure. In this chapter, we get light into some kinase/phosphatase cascades downstream of membrane receptors disrupting the dynamics of intermediate filaments and its association with neural dysfunction. However, intermediate filaments do not act individually into the neural cells. Our results evidence the importance of misregulated cytoskeletal crosstalk in disrupting cytoskeletal dynamics and cell morphology underlying neural dysfunction in experimental conditions mimicking metabolic diseases and nongenomic actions of thyroid hormones and as an end point in the neurotoxicity of organic tellurium.

show abstract

The role of the cytoskeleton during neuronal polarization

Cited by 193 publications

References 55 publications

Neuronal polarization

Neuronal polarization

F-BAR Proteins of the Syndapin Family Shape the Plasma Membrane and Are Crucial for Neuromorphogenesis

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Contact Info

Product

Resources

About