The role of the erythrocyte in the outcome of pregnancy with preeclampsia

Abstract

The objective of this study was to analyze the relationships of osmotic and mechanical stability of erythrocytes with anthropometric, biochemical, hematologic and hemodynamic variables in pregnant women with preeclampsia (PE). The studied population consisted of 20 normotensive patients and 16 patients with PE. Patients with PE presented worse gestational outcome, greater hematologic impairment, erythrocytes osmotically more stable in vitro , but in conditions of isotonicity with the in vivo medium, in addition to hyperflow in orbital territory, when compared to normotensive patients. The correlation analysis between anthropometric, hematologic and hemodynamic variables in patients with PE indicated that erythrocytes with lower volumes and lower levels of hemoglobin favor the occurrence of a better gestational outcome, because they are more stable and because they are associated with a decrease in the hemodynamic changes present in the disease. This should mean that the tendency to microcytosis, probably due to a mechanism of compensatory mechanical selection, is a desirable characteristic in the disease.

Red cell distribution width and erythrocyte osmotic stability in type 2 diabetes mellitus

“…In the population studied here, the RDW increases under the simultaneous influence of a factor associated with volume increase (reticulocyte) and other factors associated with volume decrease (lower iron levels) 50 . As RDW represents heterogeneity in the volume distribution of erythrocytes, this explains why, then, RDW was not correlated with MCV (Figure 3), although a positive correlation between those variables was reported in patients who underwent bariatric surgery 29 and a negative correlation has been found in pregnant women with pre‐eclampsia 28 …”

“…The near NaCl concentrations where lysis begins (H0) and ends (H100) were then determined according to the following equations: and as previously described. 28 Amin, H 0 , H 50 and H 100 are osmotic fragility variables and therefore have inverse relationships with the erythrocyte osmotic stability, but dX is effectively a stability variable; that is, dX increases with increasing osmotic stability of these cells.…”

“…Significant correlations were highlighted by coloured shading, and the colour density is proportional to the correlation strength (rho) not correlated with MCV (Figure 3), although a positive correlation between those variables was reported in patients who underwent bariatric surgery 29 and a negative correlation has been found in pregnant women with pre-eclampsia. 28…”

Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

“…According to a recent publication analyzing the osmotic and mechanical stability of erythrocytes, it is suggested that erythrocytes with lower volume and lower hemoglobin content are osmotically more stable. They assumed that lower MCV values could be a mechanism of compensatory mechanical selection, which is be-neficial in PE [19]. However, the desired range of MCV throughout pregnancies complicated by PE remains unclear.…”

The combination of Elephantopus scaber and Sauropus androgynus promotes erythroid lineages and modulates follicle-stimulating hormone and luteinizing hormone levels in pregnant mice infected with Escherichia coli

“…Al-Zamely and Falh [7] reported that treatment with 1×10 9 CFU/mL of E. coli decreases the hemoglobin concentration, caused by a breakdown of erythrocytes by hemolysis enzymes produced by E. coli. A decrease in erythrocytes during pregnancy results in anemia resulting from a short erythrocyte life span [8]. Bacterial infections can produce adverse effects on the erythrocyte lineage and hormone levels during pregnancy [2].…”