The Role of the gut Microbiome in the Pathogenesis and Treatment of Obesity

Okeke, Francis; Roland, Bani Chander; Mullin, Gerard E.

doi:10.7453/gahmj.2014.018

Cited by 50 publications

(36 citation statements)

References 143 publications

(179 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This obesity epidemic has been associated with an increased incidence of metabolic syndrome, certain cancers, a reduction in the quality of life, and a dramatic increase in obesity related health care costs [2, 3]. Even though many factors have been implicated in the increased prevalence of obesity, including the easy access to energy dense foods and a decrease in physical activity [2], mounting evidence supports an important role of alterations in the gut microbiome as a mediator of obesity [4]. …”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome and Obesity: A Plausible Explanation for Obesity

2015

View full text Add to dashboard Cite

Obesity is a multifactorial disorder that results in excessive accumulation of adipose tissue. Although obesity is caused by alterations in the energy consumption/expenditure balance, the factors promoting this disequilibrium are incompletely understood. The rapid development of new technologies and analysis strategies to decode the gut microbiota composition and metabolic pathways has opened a door into the complexity of the guest-host interactions between the gut microbiota and its human host in health and in disease. Pivotal studies have demonstrated that manipulation of the gut microbiota and its metabolic pathways can affect host’s adiposity and metabolism. These observations have paved the way for further assessment of the mechanisms underlying these changes. In this review we summarize the current evidence for possible mechanisms underlying gut microbiota induced obesity. The review addresses some well-known effects of the gut microbiota on energy harvesting and changes in metabolic machinery, on metabolic and immune interactions and on possible changes in brain function and behavior. Although there is limited understanding on the symbiotic relationship between us and our gut microbiome, and how disturbances of this relationship affects our health, there is compelling evidence for an important role of the gut microbiota in the development and perpetuation of obesity.

show abstract

Section: Introductionmentioning

confidence: 99%

Gut Microbiome and Obesity: A Plausible Explanation for Obesity

2015

View full text Add to dashboard Cite

show abstract

“…A limitation of investigation of the role of diet in disease is the compliance and discipline required by the patients. Not unexpectedly, obesity can lead to dysbiosis in the intestine as well [53,54]. If a modulation of diet can change the disease course or delay its development this would suggest a primary role of the gut microbiome in such diseases.…”

Section: Dietmentioning

confidence: 96%

The gut microbiome dysbiosis and its potential role in psoriatic arthritis

Eppinga¹,

Thio²,

Peppelenbosch³

et al. 2014

International Journal of Clinical Rheumatology

View full text Add to dashboard Cite

“…Linear discriminant analysis effect size (LEfSe) analysis found that s__Lactobacillus_johnsonii and s__Lactobacillus_reuteri were significantly higher bacterial species in the DF group. Lactobacillus is recognised probiotics in animal husbandry, which compete for nutrients with existing gut microbiota, which reduce body weight and fat mass 29 . The relationship of g_Lactobacillus and obesity are controversial.…”

Section: Raising Pattern Alter Intestinal Microbialmentioning

confidence: 99%

Rearing pattern alters porcine myofiber type, fat deposition, associated microbial communities and functional capacity

Men

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: The Chinese believe that the meat of pigs reared in the past with free range tastes better than that of the pigs reared indoor on a large scale today. Gastrointestinal microflora is closely associated with the main factor of meat flavour, including fibre characteristics and lipid metabolism. Our method in this study involved different raising patterns within the semi free-grazing farm (FF) or indoor feeding farm (DF), the measurement of fat deposition and myofiber type by paraffin section and reverse transcription polymerase chain reaction and the identification of microbiome and functional capacities associated with meat quality through metagenomic sequencing. Results: Results showed that the fat area in muscle and adipose tissue and the myofiber density significantly increased in the pigs of the FF group. The relative abundance of bacteria associated with lipid metabolism, such as g_Oscillibacter, in the feces of the FF group was higher than that in DF group, and the relative abundance of some bacteria with probiotic function, including g_Lactobacillus and g_Clostridium, was lower than that in DF group. The abundance of g__Clostridium was significantly positively correlated with the intramuscular fat area, whereas health-related bacteria, such as g__Butyricicoccus, g__Eubacterium, g__Phascolarctobacterium and g__Oribacterium, was significantly negatively correlated with abdominal fat area, myofiber density and adipose triglyceride lipase (ATGL) mRNA expression. KEGG analysis showed that pigs raised in semi free-grazing farm can activate the pathway of inosine monophosphate (IMP) biosynthesis, glycolysis/gluconeogenesis and alanine, aspartate and glutamate metabolism. Conclusions: Free range feeding improves meat quality by changing the fibre type, myofiber density and metabolic pathways related to flavour amino acids, IMP or glycolysis/gluconeogenesis in muscle. However, prolonged feeding cycle increases fat deposition and associated microbial communities. Keywords: Rearing pattern, Myofiber type, Fat deposition, Gut micobiota

show abstract

The Role of the gut Microbiome in the Pathogenesis and Treatment of Obesity

Cited by 50 publications

References 143 publications

Gut Microbiome and Obesity: A Plausible Explanation for Obesity

Gut Microbiome and Obesity: A Plausible Explanation for Obesity

The gut microbiome dysbiosis and its potential role in psoriatic arthritis

Rearing pattern alters porcine myofiber type, fat deposition, associated microbial communities and functional capacity

Contact Info

Product

Resources

About