The occurrence of a first-order hadron–quark matter phase transition at high baryon densities is investigated in astrophysical simulations of core-collapse supernovae, to decipher yet incompletely understood properties of the dense matter equation of state (EOS) using neutrinos from such cosmic events. It is found that the emission of a nonstandard second neutrino burst, dominated by electron antineutrinos, is not only a measurable signal for the appearance of deconfined quark matter but also reveals information about the state of matter at extreme conditions encountered at the supernova (SN) interior. To this end, a large set of spherically symmetric SN models is investigated, studying the dependence on the EOS and the stellar progenitor. General relativistic neutrino-radiation hydrodynamics is employed featuring three-flavor Boltzmann neutrino transport and a microscopic hadron-quark hybrid matter EOS class. Therefore, the DD2 relativistic mean-field hadronic model is employed, and several variations of it, and the string-flip model for the description of deconfined quark matter. The resulting hybrid model covers a representative range of onset densities for the phase transition and latent heats. This facilitates the direct connection between intrinsic signatures of the neutrino signal and properties of the EOS. In particular, a set of linear relations has been found empirically. These potentially provide a constraint for the onset density of a possible QCD phase transition from the future neutrino observation of the next galactic core-collapse SN, if a millisecond electron anti-neutrino burst is present around or less than 1 s.