The Role of the Immune System in Processes of Adaptation to Stress in Sportsmen

Surkina, I. D.; Danilenko, SV; Dudov, NS; Gotovtseva, E. P.; Ov, Koptelov; Kostina, LV; Vatagina, ON; Vorobiev, A. A.

doi:10.1042/cs087s022

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cycling ↑ PHA-stimulated PBMC supernatant 30 min after exercise [108] 90 min Lactate threshold Cycling ↓ PHA-stimulated PBMC supernatant 30 min after exercise [108] 68 min Exhaustive ↓ ConA-, LPS-stimulated PBMC supernatant 1h after exercise [94] 3 × 6 min 55, 70, 85% Cycling ↑ ConA-stimulated release after each exercise bout [115] 60% V . O2max Rowing ↓ anti-CD2, CD28-stimulated secretion in whole blood [131] 7 min Competitive Rowing ↓ production in stimulated lymphocytes [132] ConA = concanavalin-A; LPS = lipopolysaccharide; PBMC = peripheral blood mononuclear cells; PHA = phytohaemagglutinin; V . O2max = maximal oxygen uptake; ↑ indicates increase; ↓ indicates decrease; = indicates no change.…”

Section: Interferon-γ γ γ γmentioning

confidence: 99%

“…More moderate physical activity (cycle ergometry at 70% of individual anaerobic threshold for 30 minutes) induced a quantitatively similar attenuation in the ability of phytohaemagglutinin (PHA)-and staphylococcal enterotoxin B-stimulated whole blood cultures to produce the IFNγ protein. [108] However, Surkina et al [132] determined that in highly trained male rowers, 7 minutes of race simulation decreased the ability of isolated lymphocytes to produce IFNγ. The data thus far indicate that exercise has either little effect or attenuates IFNγ synthesis.…”

Section: Interferon-γ γ γ γmentioning

confidence: 99%

“…Adecrease in IFNγ response to mitogenic stimulation, and thus lower plasma concentrations of this cytokine has been suggested as contributing to an 'open window' for infections following exercise. [132,133] However, at least one group of investigators [130] has shown that plasma isolated from exercised individuals has an increased antiviral activity after exercise. Viti et al [130] used a bioassay sensitive to IFNα to investigate the effects of 60 minutes of 70% V…”

Section: Interferon-γ γ γ γmentioning

confidence: 99%

See 2 more Smart Citations

The Cytokine Response to Physical Activity and Training

2001

View full text Add to dashboard Cite

Cytokines are soluble glycoproteins that are produced by and mediate communication between and within immune and nonimmune cells, organs and organ systems throughout the body. Pro- and anti-inflammatory mediators constitute the inflammatory cytokines, which are modulated by various stimuli, including physical activity, trauma and infection. Physical activity affects local and systemic cytokine production at different levels, often exhibiting striking similarity to the cytokine response to trauma and infection. The present review examines the cytokine response to short term exercise stress, with an emphasis on the balance between pro- and anti-inflammatory mechanisms and modulation of both innate and specific immune parameters through cytokine regulation. The effects of long term exercise on cytokine responses and the possible impact on various facets of the immune system are also discussed, with reference to both cross-sectional and longitudinal studies of exercise training. Finally, the validity of using exercise as a model for trauma and sepsis is scruti- nised in the light of physiological changes, symptomatology and outcome, and limitations of the model are addressed. Further studies, examining the effect of exercise, trauma and infection on novel cytokines and cytokine systems are needed to elucidate the significance of cytokine regulation by physical activity and, more importantly, to clarify the health implications of short and long term physical activity with respect to overall immune function and resistance to infection.

show abstract