The role of the left hippocampal region in the acquisition and retention of story content

Frisk, Virginia; Milner, Brenda

doi:10.1016/0028-3932(90)90061-r

Cited by 227 publications

(125 citation statements)

References 8 publications

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“…As such, our results may be more closely related to findings of functional lateralization in the hippocampi of rodents (36) and birds (37). Overall, we suggest that involvement of the left human hippocampus in remembering narrative prose (30), learning novel sequences (38)(39)(40), and in supporting sequential egocentric representations in our study, could reflect a more general role in associative processing of sequential elements of an episode.…”

Section: Discussionsupporting

confidence: 82%

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Lateralized human hippocampal activity predicts navigation based on sequence or place memory

Igloi

Doeller

Berthoz

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

255

184

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The hippocampus is crucial for both spatial navigation and episodic memory, suggesting that it provides a common function to both. Here we adapt a spatial paradigm, developed for rodents, for use with functional MRI in humans to show that activation of the right hippocampus predicts the use of an allocentric spatial representation, and activation of the left hippocampus predicts the use of a sequential egocentric representation. Both representations can be identified in hippocampal activity before their effect on behavior at subsequent choice-points. Our results suggest that, rather than providing a single common function, the two hippocampi provide complementary representations for navigation, concerning places on the right and temporal sequences on the left, both of which likely contribute to different aspects of episodic memory.T he hippocampus plays a crucial role in both spatial navigation and episodic memory (1-6). However, the nature of the fundamental hippocampal process or representation that might underlie both functions remains the subject of intense speculation, including suggestions that it is best characterized as associative (7), sequential (8), flexible relational (2), allocentric (1, 5, 9), or spatial contextual (4, 5). Similar speculation surrounds the nature of any lateralization of these representations (1, 5, 10), and whether the firing of hippocampal neurons in freely moving rodents reflects allocentric position, spatial context, or sequential position along a route (5, 11, 12). Here we show that the hippocampus predicts and supports navigation via sequential representations in the left hippocampus and allocentric spatial representations in the right hippocampus. These complementary lateralized representations suggest an explanation for the multiple hippocampal contributions to different aspects of spatial and episodic memory.Within spatial memory a distinction has been made between "allocentric" (world-centered) and "egocentric" (body-centered) representations, with allocentric (or place-learning) and simple egocentric (stimulus response-like) navigation shown to depend on the hippocampus and dorsal striatum, respectively, in rodents (5, 13). recently demonstrated that an additional sequential egocentric representation depends on the rodent hippocampus. The human hippocampus has likewise been associated with allocentric representations of location, allowing accurate navigation from new starting locations (15) based on the configuration of environmental cues (16, 17) or recognition of locations from a new viewpoint (18,19). Similarly, navigation via a fixed route (15, 17) or relative to a single landmark (16), consistent with simple egocentric representations, has been associated with the dorsal striatum. However, to our knowledge, the neural bases of the sequential egocentric representation have not yet been identified in humans, and could provide a link between spatial navigation and episodic memory.Here we adapt the Starmaze task developed for mice (14,20) to investigate the neural base...

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Section: Discussionsupporting

confidence: 82%

“…The left hippocampus has long been implicated in verbal tasks, such as the learning of narrative prose (30) or the learning and retrieval of word lists (31, see also ref. 5).…”

Section: Discussionmentioning

confidence: 99%

Lateralized human hippocampal activity predicts navigation based on sequence or place memory

Igloi

Doeller

Berthoz

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

255

184

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“…This is in line with the assumed role of the hippocampus in episodic memory (Deweer et al, 2001), as a substantial inter-subject variability would be expected. A key role for the left hippocampus in retention of story material has been previously reported (Frisk and Milner, 1990). The hippocampus has also been implicated in working memory (Cabeza et al, 2002;Ranganath and D'esposito, 2001), as well as a transitional function for long-term memory (Kato et al, 1998).…”

Section: Discussionmentioning

confidence: 75%

Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study

2006

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The ability to comprehend narratives constitutes an important component of human development and experience. The neural correlates of auditory narrative comprehension in children were investigated in a large-scale functional magnetic resonance imaging (fMRI) study involving 313 subjects ages 5-18. Using group Independent Component Analysis (ICA), bilateral task-related components were found comprising the primary auditory cortex, the mid-superior temporal gyrus, the hippocampus, the angular gyrus and medial aspect of the parietal lobule (precuneus/posterior cingulate). In addition, a right-lateralized component was found involving the most posterior aspect of the superior temporal gyrus, and a left-lateralized component was found comprising the inferior frontal gyrus (including Broca's area), the inferior parietal lobule, and the medial temporal gyrus. Using a novel data-driven analysis technique, increased task-related activity related to age was found in the components comprising the mid-superior temporal gyrus (Wernicke's area) and the posterior aspect of the superior temporal gyrus, while decreased activity related to age was found in the component comprising the angular gyrus. The results are discussed in light of recent hypotheses involving the functional segregation of Wernicke's area and the specific role of the mid-superior temporal gyrus in speech comprehension.

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“…The right temporal lobe has been linked to memory for material that is difficult to verbalize (e.g., faces, complex designs) (Lezak, 1995 Milner, 1990;199 1 ;Milner, 19%;1972 The second group study that assessed neuropsychological deficits in MCS was conducted by Simon et al (1993). Groups of patients with cerebral lesions of the same region have been studied to observe the consequences of loss of fiuiction thought to be associated with that region.…”

Section: Cognitive Deficits In Indmduals Exposed To Solventsmentioning

confidence: 99%

Multiple Chemical Sensitivity: A Test of the Olfactory-Limbic Model

Brown-DeGagne

McGlone

1999

Journal of Occupational & Environmental Medicine

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The role of the left hippocampal region in the acquisition and retention of story content

Cited by 227 publications

References 8 publications

Lateralized human hippocampal activity predicts navigation based on sequence or place memory

Lateralized human hippocampal activity predicts navigation based on sequence or place memory

Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study

Multiple Chemical Sensitivity: A Test of the Olfactory-Limbic Model

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