The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole

Turek, Artur; Rech, Jakub; Borecka, Aleksandra; Wilińska, Justyna; Kobielarz, Magdalena; Janeczek, Henryk; Kasperczyk, Janusz

doi:10.3390/polym13203556

Cited by 3 publications

(18 citation statements)

References 25 publications

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“…A T g close to human body temperature may result in a shorter lag phase. The HME and the introduction of ARP did not influence the terpolymer composition (Figure 7 and Table 3), which reflects previous studies [12,13,22,27].…”

Section: Terpolymer Compositionsupporting

confidence: 87%

“…The HME and the introduction of ARP did not influence the terpolymer composition (Figure 7 and Table 3), which reflects previous studies [12,13,22,27]. In the case of PLGA copolymers, the value of the M n is an important parameter to tailor the release profile of drug substances [18].…”

Section: Terpolymer Compositionsupporting

confidence: 81%

“…This feature may ensure higher bioavailability compared to semi-crystalline material. This attribute was suggested in the previous study of P(LA:GA:TMC) terpolymers releasing 17-β-estradiol and aripiprazole [13,22].…”

Section: Characterization Of Raw Terpolymersmentioning

confidence: 53%

“…Area (µm Previously, it was revealed that the presence of risperidone or ARP influenced the increase in morphological diversity of implantable rods based on poly(lactide-co-glycolideco-trimethylene carbonate) terpolymers [12,13]. In this study, the thesis presented in the literature was developed by calculations using ImageJ ® software.…”

Section: Samplementioning

confidence: 99%

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Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study

Wilińska,

Turek,

Rech

et al. 2023

Applied Sciences

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Aripiprazole (ARP) is an atypical neuroleptic used in the therapy of mental diseases such as schizophrenia. The lack of optimal adherence to an oral therapy regime creates the basis for designing ARP long-acting injections. This study aimed to use 105 °C hot melt extrusion (HME) as a formulation method for rods based on poly(d,l-lactide-co-glycolide-co-trimethylene carbonate) with a molecular weight (Mn) of 21 kDa (Td,l 21), poly(l-lactide-co-glycolide-co-trimethylene carbonate) with a Mn of 59 kDa (Tl 59), and with a Mn of 77 kDa (Tl 77). The following methods were involved in the research: NMR, DSC, XRD, HSM, FTIR, GPC, SEM, and mechanical tests. HME at 105 °C (i) ensured flow behavior for terpolymers, (ii) did not influence the terpolymers’ composition and (iii) the polymorph changes of ARP, and (iv) resulted in the changes in terpolymers’ Mn. For the rods with ARP based on Td,l 21 (Td,l 21 rod-ARP) and Tl 59 (Tl 59 rod-ARP), plasticization was noted. No drug–terpolymer interactions were revealed. No pores were observed on the surface. Due to its high flexibility and rubber character, Td,l 21 rod-ARP may be proposed for intramuscular administration, whereas Tl 59 rod-ARP, due to its higher strength and moderate stiffness, is proposed for subcutaneous administration.

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Section: Terpolymer Compositionsupporting

confidence: 87%

Section: Terpolymer Compositionsupporting

confidence: 81%

Section: Characterization Of Raw Terpolymersmentioning

confidence: 53%

Section: Samplementioning

confidence: 99%

See 2 more Smart Citations

Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study

Wilińska,

Turek,

Rech

et al. 2023

Applied Sciences

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“…This solution significantly increases the accumulation of a large volume of therapeutic agents in the brain, resulting in improved therapeutic effects [ 25 ]. Another promising concept is implantable and biodegradable rods based on poly( l -lactide- co -glycolide- co -trimethylene carbonate) (P( l -LA:GA:TMC)), with aripiprazole (ARP) administered via a ampoule syringe as an alternative to small microparticles administered as suspensions [ 26 ]. It is also worth mentioning the use of terpolymer-shaped memory rods, which, in addition to their use in CNS diseases, can be used in nerve regeneration [ 27 ].…”

Section: Limitations Of Currently Used Drug Delivery Systems To the C...mentioning

confidence: 99%

Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases

Nowak,

Madej,

Secemska

et al. 2023

Pharmaceutics

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Central nervous system (CNS) diseases are currently a major challenge in medicine. One reason is the presence of the blood–brain barrier, which is a significant limitation for currently used medicinal substances that are characterized by a high molecular weight and a short half-life. Despite the application of nanotechnology, there is still the problem of targeting and the occurrence of systemic toxicity. Viral vectors and virus-like particles (VLPs) may provide a promising solution to these challenges. Their small size, biocompatibility, ability to carry medicinal substances, and specific targeting of neural cells make them useful in research when formulating a new generation of biological carriers. Additionally, the possibility of genetic modification has the potential for gene therapy. Among the most promising viral vectors are adeno-associated viruses, adenoviruses, and retroviruses. This is due to their natural tropism to neural cells, as well as the possibility of genetic and surface modification. Moreover, VLPs that are devoid of infectious genetic material in favor of increasing capacity are also leading the way for research on new drug delivery systems. The aim of this study is to review the most recent reports on the use of viral vectors and VLPs in the treatment of selected CNS diseases.

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Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment

et al. 2023

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Latanoprost (LTP) is a prostaglandin F2α analog used to lower intraocular pressure in glaucoma treatment administered daily as eye drops. In this study, a universal model based on poly(l-lactide-co-glycolide-co-trimethylene carbonate) with shape memory was proposed for the development of a solid biodegradable formulation with prolonged release administered intraconjunctivally, intravitreally, subconjunctivally, and subcutaneously. Solution casting and electron beam (EB) irradiation were applied to the matrix formulation. The properties of the native matrix and matrices degraded in a PBS buffer (pH 7.4) were monitored by NMR, DSC, GPC, and SEM. Water uptake (WU) and weight loss (WL) were also analyzed. LTP was released over 113 days in a tri-phasic and sigmoidal pattern without a burst effect and with a relatively long second release phase, in which changes were observed in the glass transition temperature, molecular weight (Mn), WU, and WL. EB irradiation decreased the initial Mn, increased WU, and accelerated LTP release with a shortened lag phase. This provides the opportunity to partially eliminate the use of drops at the start of treatment. SEM observations indicated that surface erosion is the prevalent degradation mechanism. The proposed model is an interesting solution during a preliminary study to develop final medicinal products that provide high adherence.

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The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole

Cited by 3 publications

References 25 publications

Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study

Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study

Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases

Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment

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