The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells

Zhao, Chong; Wang, Xiaoya; Gao, Long; Jing, Linguo; Zhou, Quan; Chang, Jiang

doi:10.1016/j.actbio.2018.04.030

Cited by 116 publications

(101 citation statements)

References 63 publications

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“…Moreover, the presence of HAp led to a higher matrix mineralization as soon as 7 days, suggesting an induction of osteogenic differentiation of hASCs. Results from the literature show that the micropattern of hydroxyapatite in materials seems to induce a higher promotion in early cells adhesions and subsequent osteogenic differentiation …”

Section: Discussionmentioning

confidence: 99%

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

Calejo

Costa‐Almeida

Reis

et al. 2019

Adv Healthcare Materials

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Tendon‐to‐bone interfaces exhibit a hierarchical multitissue transition. To replicate the progression from mineralized to nonmineralized tissue, a novel 3D fibrous scaffold is fabricated with spatial control over mineral distribution and cellular alignment. For this purpose, wet‐spun continuous microfibers are produced using polycaprolactone (PCL)/ gelatin and PCL/gelatin/hydroxyapatite nano‐to‐microparticles (HAp). Higher extrusion rates result in aligned PCL/gelatin microfibers while, in the case of PCL/gelatin/HAp, the presence of minerals leads to a less organized structure. Biological performance using human adipose‐derived stem cells (hASCs) demonstrates that topography of PCL/gelatin microfibers can induce cytoskeleton elongation, resembling native tenogenic organization. Matrix mineralization on PCL/gelatin/HAp wet‐spun composite microfibers suggest the production of an osteogenic‐like matrix, without external addition of osteogenic medium supplementation. As proof of concept, a 3D gradient structure is produced by assembling PCL/gelatin and PCL/gelatin/HAp microfibers, resulting in a fibrous scaffold with a continuous topographical and compositional gradient. Overall, the feasibility of wet‐spinning for the generation of continuously aligned and textured microfibers is demonsrated, which can be further assembled into more complex 3D gradient structures to mimic characteristic features of tendon‐to‐bone interfaces.

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Section: Discussionmentioning

confidence: 99%

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

Calejo

Costa‐Almeida

Reis

et al. 2019

Adv Healthcare Materials

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“…In addition, their results also revealed signicantly enhanced cell adhesion, proliferation and expression of osteogenic genes on both patterned surfaces, compared to at control. 48 HAp coating with nanorod-structures on Ti 6 Al 4 V implants were applied to promote cell adhesion and osteointegration in diabetes mellitus rabbit models. 49 The importance of distinct architecture of the biomaterial surface were recently reviewed.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal stem cell interaction with Ti₆Al₄V alloy pre-exposed to simulated body fluid

et al. 2020

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“…The HA scaffolds with micro/nano hybrid structures distinctly facilitate the osteogenic differentiation of hBMSCs and have the capability to promote the regeneration of bone. hBMSCs, human bone mesenchymal stem cells; S0, flat surface; S1, nanorod structured surface; S2, micropattern structured surface; S3, micropattern/nanorod hybrid structured surface (Zhao et al, 2018) scaffolds distinctly promoted osteogenic differentiation and represented a promising strategy for osteochondral regeneration (Guancong et al, 2014). However, apart from encouraging the discovery of HA nanoparticles in osteochondral differentiation, this research has prominent shortcomings.…”

Section: Nanobased Scaffold Modificationmentioning

confidence: 99%

Advances of nanotechnology in osteochondral regeneration

Deng

Zhou

et al. 2019

WIREs Nanomed Nanobiotechnol

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In the past few decades, nanotechnology has proven to be one of the most powerful engineering strategies. The nanotechnologies for osteochondral tissue engineering aim to restore the anatomical structures and physiological functions of cartilage, subchondral bone, and osteochondral interface. As subchondral bone and articular cartilage have different anatomical structures and the physiological functions, complete healing of osteochondral defects remains a great challenge. Considering the limitation of articular cartilage to self‐healing and the complexity of osteochondral tissue, osteochondral defects are in urgently need for new therapeutic strategies. This review article will concentrate on the most recent advancements of nanotechnologies, which facilitates chondrogenic and osteogenic differentiation for osteochondral regeneration. Moreover, this review will also discuss the current strategies and physiological challenges for the regeneration of osteochondral tissue. Specifically, we will summarize the latest developments of nanobased scaffolds for simultaneously regenerating subchondral bone and articular cartilage tissues. Additionally, perspectives of nanotechnology in osteochondral tissue engineering will be highlighted. This review article provides a comprehensive summary of the latest trends in cartilage and subchondral bone regeneration, paving the way for nanotechnologies in osteochondral tissue engineering. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells

Cited by 116 publications

References 63 publications

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

Mesenchymal stem cell interaction with Ti₆Al₄V alloy pre-exposed to simulated body fluid

Advances of nanotechnology in osteochondral regeneration

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The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells

Cited by 116 publications

References 63 publications

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon‐to‐Bone Interface Gradient Scaffolds

Mesenchymal stem cell interaction with Ti6Al4V alloy pre-exposed to simulated body fluid

Advances of nanotechnology in osteochondral regeneration

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Mesenchymal stem cell interaction with Ti₆Al₄V alloy pre-exposed to simulated body fluid