The Role of the NOD1/Rip2 Signaling Pathway in Myocardial Remodeling in Spontaneously Hypertensive Rats

Liu, Fengyi; Fang, Bing-Qian; Sun, Ling-Min; Zhang, Xiuzhen; Liu, Jinli; Yang, Yuzhe; Zhang, Wenhua; Wang, Xiuli; Ding, Yanchun

doi:10.12659/msm.924748

Cited by 1 publication

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References 49 publications

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“…Our previous study indicated that the expression of NOD1/Rip2 was up-regulated during the progression of myocardial remodelling in SHRs. In addition, the activation of NOD1/Rip2 signalling pathway triggered the expression of downstream cytokine IL-1, which might then lead to the aggravation of the myocardial remodelling (Liu et al 2020). In this study, vascular remodelling was noticed in the carotid artery in the SHRs group at week 12 and 16, which was featured by increase in the media thickness of artery, ratio of media thickness to lumen A B diameter, as well as cross-section area of media.…”

Section: Discussionmentioning

confidence: 52%

Roles of NOD1/Rip2 signal pathway in carotid artery remodelling in spontaneous hypertensive rats

Zhang¹,

Fang²,

Sun³

et al. 2022

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Nucleotide-binding and oligomerization domain (NOD) receptor is a member of inherent immunity recognition receptor family. We investigated the NOD1/Rip2 signalling pathway on carotid arterial remodelling in spontaneously hypertensive rats (SHRs). SHRs were treated with NOD1 agonist (iE-DAP), inhibitor (ML130), or normal saline. We determined the NOD1 and Rip2 expression in carotid artery tissues, serum tumour necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1). The carotid artery remodelling in 16-week SHRs was higher than that of 8-week SHRs and 16-week Wistar-Kyoto (WKY) rats. Expression of NOD1, Rip2, MCP-1 and TNF-α in 16-week SHRs was higher than that of 8-week SHRs and 16-week WKY rats. Blood pressure in iE-DAP-treated SHRs was higher than SHR-C group (no treatment), together with MCP-1, TNF-α, NOD1 and Rip2 expression, as well as carotid artery remodelling. In ML130-treated group, these aspects were completely the opposite. Taken together, inhibition of NOD1/Rip2 signalling pathway could delay the vascular remodelling process.

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Section: Discussionmentioning

confidence: 52%