The role of the renin-angiotensin system, immunological and genetic factors in children with COVID-19

Nikitina, I. V.; Донников, А Е; Крог-Йенсен, О. А.; Ленюшкина, А А; Дегтярева, Н. Д.; Дегтярева, А. В.

doi:10.21508/1027-4065-2020-65-4-16-26

Cited by 9 publications

(3 citation statements)

References 47 publications

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“…The likelihood of SARS-CoV-2 infection in humans also depends on the genetically determined ACE2 expression. Genetic predisposition to develop severe forms of COVID-19 may result from certain polymorphisms of genes that are involved in the regulation of vascular tone, cell growth, and proliferation [6]. After analyzing genomic studies on the association of renin-angiotensin system (RAS) components with cardiovascular, pulmonary, and other pathologies, Nikitina et al [6] concluded that specific polymorphisms in the human genes encoding AGTR1, AGTR2, ACE2, and ACE proteins can lead to an imbalance in RAS.…”

Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

“…Genetic predisposition to develop severe forms of COVID-19 may result from certain polymorphisms of genes that are involved in the regulation of vascular tone, cell growth, and proliferation [6]. After analyzing genomic studies on the association of renin-angiotensin system (RAS) components with cardiovascular, pulmonary, and other pathologies, Nikitina et al [6] concluded that specific polymorphisms in the human genes encoding AGTR1, AGTR2, ACE2, and ACE proteins can lead to an imbalance in RAS. The response of pneumocytes, vascular endothelium and smooth muscle fibers during SARS-CoV-2 infection may be much more pronounced in carriers of unfavorable genetic variations due to a shift towards the vasoconstrictor, proliferative, and profibrotic processes.…”

Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

“…The RAS biochemical cascade is considered to be a key element in the pathogenesis of COVID-19. Nikitina et al [6] described it from two points of view: ACE2 expression on the cell surface and genetic polymorphisms of the RAS system. First, the transmembrane protein ACE2 serves as a " gateway" for SARS-CoV-2.…”

Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

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Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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Due to the prevalence and diversity of both symptoms and outcomes of COVID-19, understanding the factors that determine the risk of the severe course of this disease and its possible complications is of particular importance. In this review, we present the information on the specifics of COVID-19 pathogenesis and give a theoretical justification for the factors that determine the course of this disease in patients of different age groups, patients with chronic pathology, and pregnant women. Particular attention is paid to the post-COVID syndrome.

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Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

Section: Mechanisms Of Covid-19 Pathogenesis and Sars-cov-2 As The Ca...mentioning

confidence: 99%

See 1 more Smart Citation

Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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A relation between specific immune status indicators and activity of “lipid peroxidation — antioxidant defense” system in COVID-19 neonates

Rychkova,

Darenskaya,

Petrova

et al. 2023

Russian Journal of Infection and Immunity

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The 2019 coronavirus infection (COVID-19) has not been considered as a solved issue for public health. Pregnant women and newborns are specifically vulnerable to COVID-19 infection compared to older children and healthy young adults. Virtually no data on relation between diverse arms of immunity in patients in neonatal period and coronavirus infection are available. The obtained results can contribute to a better understanding of the pathogenetic mechanisms on reactivity of immune processes in young patients and corresponding formation of approaches for prevention and correction of such disorders. The aim of the study was to determine magnitude of specific altered parameters in immune system and their relation with lipid peroxidation parameters in COVID-19 newborns. Two groups of newborns (mean age 43.1 days) were examined: SARS-CoV-2-positive (COVID-19 patients, n = 44) and negative (control group, n = 80) PCR test of nasopharyngeal swab. All newborns were assessed for specific indicators of peripheral blood immune status and lipid peroxidation activity. The concentration of Th1-pro-inflammatory cytokines and Th2-anti-inflammatory interleukins was assessed by enzyme immunoassay method (a panel of monoclonal antibodies). Spectrophotometric, fluorometric and enzyme immunoassay methods to evaluate the lipid peroxidation system were used. According to our data, newborns with COVID-19 vs. healthy newborns had decreased CRP, pro-inflammatory cytokines TNF, IL-1, IL-6, IL-8, and anti-inflammatory factor (IL-4). Change in lipid peroxidation system in children with COVID-was 19 related to higher level of DC, KD and CT, TBARs, increased SOD activity and reduced GPO. Numerous intersystem dependencies in the group of newborns with COVID-19 (CRP Total AOA, IL-4 KD and CT, IL-4 TBARs, IL-4 Total AOA, IL-4 SOD, IL-8 SOD, IFN GSH) were noted. It can be concluded that in newborns with COVID-19, changes in the immune system are nonspecific and are accompanied by an increased intensity of lipid peroxidation reactions against the background of reduced values of pro- and anti-inflammatory cytokines. These results may contribute to a more accurate assessment of intensity and dynamics of emerging neonatal coronavirus infection, which should be an important arm in preventing subsequent complications.

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