The role of the retinal interplexiform cell: effects of 6-hydroxydopamine on the spatial properties of carp horizontal cells

Cohen, Joel L.; Dowling, John E.

doi:10.1016/0006-8993(83)90830-2

Cited by 51 publications

(21 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dopamine has also been shown to decrease the diffusion of fluorescent dye between horizontal cells (18,19), suggesting that dopamine decreases receptive field size by altering the electrical coupling between horizontal cells. A dopamine-sensitive adenylate cyclase has been localized to horizontal cells in carp (21), providing the hypothesis that cyclic AMP may be involved in modifying the electrical coupling between these cells (22). Experiments showing that analogs of cyclic AMP and forskolin, an activator of adenylate cyclase, mimic dopamine in restricting receptive field diameter and dye diffusion between horizontal cells provide evidence in favor of this hypothesis (18,19).…”

mentioning

confidence: 66%

Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells.

Lasater¹,

Dowling²

1985

Proc. Natl. Acad. Sci. U.S.A.

253

140

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 66%

Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells.

Lasater¹,

Dowling²

1985

Proc. Natl. Acad. Sci. U.S.A.

253

140

View full text Add to dashboard Cite

show abstract

“…Vaney (1985) reports preliminary evidence that the dopamine antagonist haloperidol increases dye coupling between AI1 amacrines and other neurons of the inner nuclear layer. In support of this possibility, there is strong evidence that dopamine participates in the control of gap junctions between horizontal cells in the outer plexiform layer (Negishi and Drujan, 1979;Cohen and Dowling, 1983). However, as suggested by WLssle et al (1986), it is unlikely that transmitter spillover would occur between cells using different transmitters.…”

Section: Autoradiographymentioning

confidence: 83%

A combined Golgi and autoradiographic study of 3H-glycine-accumulating cone bipolar cells in the cat retina

Pourcho¹,

Goebel²

1987

J. Neurosci.

View full text Add to dashboard Cite

Morphological subclasses of cone bipolar cells in the cat retina were studied in Golgi preparations and through the combination of Golgi impregnation with quantitative electron-microscopic autoradiography of 3H-glycine accumulation. Camera lucida drawings, computer-assisted rotations, and radial sections provided the morphological details used in assigning individual cells to morphologically defined subclasses. Selected Golgi-impregnated cells from retinas preloaded with 3H-glycine were sectioned for autoradiographic analysis. Grain densities were quantitated and compared on a normalized scale with the labeling of amacrine cells with 3H-glycine. Eleven types of cone bipolar cells were identified, 6 with axon terminals ramifying in sublamina a and 5 with axons terminating in sublamina b. Of these cells, types CBb2 and CBb5 showed the highest affinity for glycine, with labeling at 41 and 38% with respect to the most heavily labeled amacrine cells. Types CBb1, CBb3, CBa2, and CBa6 were labeled at approximately 20% of maximal labeling. The accumulation of glycine by these cells suggests that they may be involved in providing inhibitory input to the inner retina.

show abstract

“…Thus, horizontal cells can influence their own synaptic inputs through direct or polysynaptic loops. Horizontal cells, moreover, are electrically coupled through a network of gap junctions (Kaneko, 1971;Witkovsky, Owen & Woodworth, 1983) and there is increasing evidence that the permeability of such junctions can be altered by neurotransmitters (Piccolino, Neyton, Witkovsky & Gerschenfeld, 1982;Cohen & Dowling, 1983;Teranishi, Negishi & Kato, 1983). …”

Section: Introductionmentioning

confidence: 99%

The actions of gamma‐aminobutyric acid, glycine and their antagonists upon horizontal cells of the Xenopus retina.

Stone¹,

Witkovsky²

1984

The Journal of Physiology

View full text Add to dashboard Cite

We examined the effects of gamma‐aminobutyric acid (GABA) and glycine and their respective antagonists, picrotoxin and strychnine, upon the membrane potential and light‐evoked responses of the type H1 horizontal cell of the Xenopus retina. This horizontal cell receives mixed input from rod and cone receptors. Under control conditions the mean membrane potential was ‐37.8 +/‐ 9.7 mV. Addition of 5 mM‐GABA to the superfusate hyperpolarized the cell by 4.0 +/‐ 2.6 mV within 3‐5 min; addition of 0.5 mM‐picrotoxin depolarized the cell by 4.3 +/‐ 2.1 mV. Prolonged (greater than 15 min) exposures to the drugs elicited more pronounced changes in membrane potential. GABA and picrotoxin affected primarily the cone‐dependent input to the H1 horizontal cell. Under dark‐adapted conditions, response wave forms were essentially unaltered by the drugs, but when the horizontal cell was moderately or fully light adapted, GABA reduced and picrotoxin enhanced the cone‐dependent component of its response to light. Long‐term (greater than 15 min) exposures to GABA and picrotoxin elicited changes in response kinetics usually associated with dark and light adaptation, respectively. Glycine, at bath concentrations of 0.6 mM or greater, depolarized horizontal cells by 21 mV on average and reduced or abolished their light response. This action did not occur in the presence of 0.1 mM‐strychnine. When all light‐evoked activity was blocked by 20‐40 mM‐magnesium, the depolarizing action of glycine still occurred. Thus, glycine appears to act directly upon the horizontal cell membrane. Neither GABA nor glycine, nor their respective antagonists, affected the spatial extent of the horizontal cell receptive field.

show abstract

The role of the retinal interplexiform cell: effects of 6-hydroxydopamine on the spatial properties of carp horizontal cells

Cited by 51 publications

References 11 publications

Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells.

Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells.

A combined Golgi and autoradiographic study of 3H-glycine-accumulating cone bipolar cells in the cat retina

The actions of gamma‐aminobutyric acid, glycine and their antagonists upon horizontal cells of the Xenopus retina.

Contact Info

Product

Resources

About