The role of the rodent lateral orbitofrontal cortex in simple Pavlovian cue-outcome learning depends on training experience

Panayi, Marios C.; Killcross, Simon

doi:10.1101/2020.10.16.342832

Cited by 4 publications

(7 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite inactivation, rats in both groups progressively increased responding to the food cup during presentation of either cue (Figure 1D). Initial acquisition rates were similar, although rats in the hM4d group responded slightly less during the last two sessions of conditioning, in agreement with recent work showing that transient OFC inactivation can reduce asymptotic conditioned responding in some settings 24 .…”

Section: Resultssupporting

confidence: 90%

The role of the orbitofrontal cortex in creating cognitive maps

Costa

Scholz

Lloyd

et al. 2022

Preprint

View full text Add to dashboard Cite

We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created. The orbitofrontal cortex (OFC) is typically thought to access these maps to support model-based decision-making, but it has recently been proposed that its critical contribution may be instead to integrate information into existing and new models. We tested between these alternatives using an outcome-specific devaluation task and a high-potency chemogenetic approach. We found that selectively inactivating OFC principal neurons when rats learned distinct cue-outcome associations, but prior to outcome devaluation, disrupted subsequent model-based inference, confirming that the OFC is critical for creating new cognitive maps. However, OFC inactivation surprisingly led to generalized devaluation. Using a novel reinforcement learning framework, we demonstrate that this effect is best explained not by a switch to a model-free system, as would be traditionally assumed, but rather by a circumscribed deficit in defining credit assignment precision during model construction. We conclude that the critical contribution of the OFC to learning is regulating the specificity of associations that comprise cognitive maps.

show abstract

Section: Resultssupporting

confidence: 90%

The role of the orbitofrontal cortex in creating cognitive maps

Costa

Scholz

Lloyd

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Given that pretraining OFC lesions enhanced acquisition behavior, we expected that posttraining OFC dysfunction would also enhance acquisition. Surprisingly, posttraining OFC inactivation (Figure 2a) and lesions (Panayi & Killcross, 2020) significantly impaired acquisition. Specifically, whereas control animals continued to acquire responding, responding did not change when OFC was inactivated (Sessions 12–15).…”

Section: Resultsmentioning

confidence: 93%

“…This might suggest that OFC inactivation may have disrupted the behavioral expression but not underlying learning during acquisition in this task. The opposing effects of pre- and posttraining OFC dysfunction might simply reflect differences in the compensatory function of other neural regions (in-depth discussion of alternative explanations are considered in Panayi & Killcross, 2020). The computational results presented hereafter suggest that this can also be interpreted in terms of a transiently disrupted arbitration mechanism while learning in the MB system was spared…”

Section: Resultsmentioning

confidence: 99%

“…Surprisingly, we have recently found that lateral OFC lesions in rats significantly disrupt simple single CS–US Pavlovian acquisition (Panayi & Killcross, 2020). Furthermore, whereas pretraining lesions significantly enhanced acquisition after extended training, posttraining lesions and functional inactivation impaired subsequent acquisition.…”

Section: Cardinal Features Of Ofc Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

The rodent lateral orbitofrontal cortex as an arbitrator selecting between model-based and model-free learning systems.

Panayi¹,

Khamassi²,

Killcross³

2021

Behavioral Neuroscience

Self Cite

View full text Add to dashboard Cite

Our understanding of orbitofrontal cortex (OFC) function has progressed remarkably over the past decades in part due to theoretical advances in associative and reinforcement learning theories. These theoretical accounts of OFC function have implicated the region in progressively more psychologically refined processes from the value and sensory specific properties of expected outcomes to the representation and inference over latent state representations in cognitive maps of task space. While these accounts have been successful at modelling many of the effects of causal manipulation of OFC function in both rodents and primates, recent findings suggest that further refinement of our current models are still required. Here we briefly review how our understanding of OFC function has developed to understand two cardinal deficits following OFC dysfunction: reversal learning and outcome devaluation. We then consider recent findings that OFC dysfunction also significantly affects initial acquisition learning, often assumed to be intact. To account for these findings, we consider a possible role for the OFC in the arbitration and exploration between model-free and model-based learning systems, off-line updating of model-based representations. While the function of the OFC as a whole is still likely to be integral to the formation and use of a cognitive map of task space, these refinements suggest a way in which distinct orbital subregions, such as the rodent lateral OFC, might contribute to this overall function.

show abstract

“…The OFC is required for aspects of what is learned even in simple conditioning. 13,14 By inactivating OFC in a temporally specific manner only during pre-exposure, our chemogenetic approach provides a much more definitive test of the specific hypothesis that the OFC is required when it is necessary to infer that the PE cue predicts the absence of reward and should thus be ignored.…”

Section: Resultsmentioning

confidence: 99%