The Role of the Therapeutic Regimen in Dosage Design. Part I

Krüger-Thiemer, Ekkehard; Bünger, Paul

doi:10.1159/000220395

Cited by 59 publications

(19 citation statements)

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“…The situations after repeated doses would be completely different and could be described by applying the principle of superposition, using the results for the single dose, as known in classical pharmacokinetics. 2056,2065–2068 …”

Section: Numerical Simulations For Multi-bilayer Systemsmentioning

confidence: 99%

Modeling Kinetics of Subcellular Disposition of Chemicals

Baláž

2009

Chem. Rev.

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Section: Numerical Simulations For Multi-bilayer Systemsmentioning

confidence: 99%

Modeling Kinetics of Subcellular Disposition of Chemicals

Baláž

2009

Chem. Rev.

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“…However, some of the most interesting cases involve drug levels that approach or exceed the binding capacity of the plasma proteins, where such a relationship will not hold. Kriiger-Thiemer et al (16) presented some more sophisticated derivations of expressions relating plasma binding to pharmacokinetics, but they found it necessary to assume either a one-compartment I I bound Scheme I model or instantaneous distribution of drug between two compartments. Even in the simple two-compartment case, the solution was presented in an inverse form which does not allow calculation of drug concentrations at specified times.…”

mentioning

confidence: 99%

Numerical Solution of Nonlinear Pharmacokinetic Equations: Effects of Plasma Protein Binding on Drug Distribution and Elimination

Coffey

Bullock

Schoenemann

1971

Journal of Pharmaceutical Sciences

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“…It has been suggested 6 that the administration of a maintenance dose at dosage intervals equivalent to one biologic half-life usually constitutes a suitable regimen for most drugs. Consequently, a 12 hour dosing schedule is satisfactory for the 4 drugs studied, since the biologic half- lives range from 10.8 to 16.6 hours.…”

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Influence of repetitive dosing of tetracyclines on biologic half‐life in serum

Doluisio

Dittert

1969

Clin Pharma and Therapeutics

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The apparent biologic half-lives of tetracycline, demethylchlortetracycline, methacycline, and doxycycline were found to increase from 6.3, 11, 7, and 8.3 hours to 10, 14.7, 11, and 14.5 hours, respectively, during Drug concentrations in serum are useful in evaluating the relative availability of a drug following administration of drug products.'"' If urine excretion data is also Received for publication May, 16, 1969. Accepted for publication June 25, 1969. 0 1t is important to recognize the difference between the terms "drug'' and "drug product" as they are used in this report. A "drug" is the chemical substance responsible for antibiotic activity, whereas a "drug product" is a specific chemical and physical form of the active substance. The blood levels of drug produced by drug products are directly influenced by the chemical form of the drug (i.e., the phosphate complex) and the characteristics of the dosage form (i.e., fillers, binders, particle size of the active ingredient, etc.) as well as the pharmacodynamic properties of the drug itself (i.e., serum binding, metabolism, excretion, etc.). Thus, in this report the specific trade name (and lot number) of the drug product is used in the discussion when formulation factors are important and the chemical name of the drug is used when formulation factors are expected to have little influence. 690 available, mathematical treatment of the data enables one to calculate individual rate constants for the absorption, distribution, metabolism, and excretion processes. '3

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The Role of the Therapeutic Regimen in Dosage Design. Part I

Cited by 59 publications

References 0 publications

Modeling Kinetics of Subcellular Disposition of Chemicals

Modeling Kinetics of Subcellular Disposition of Chemicals

Numerical Solution of Nonlinear Pharmacokinetic Equations: Effects of Plasma Protein Binding on Drug Distribution and Elimination

Influence of repetitive dosing of tetracyclines on biologic half‐life in serum

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