This study explores social networks of COVID-19 in South Korea according to a multitude of geographical scales, regions, and topics. This study finds that key players play a different role in social networks according to the national level, regional level, and topic level. For example, politicians play the most important role in communications of COVID-19 in the South Korea networks, whereas no politicians exert a significant impact on the Shincheonji networks. Second, newspaper and politicians exert a strong impact on social networks for COVID 19. Among 40 key players for COVID 19, newspapers have the highest proportion (35%), followed by politicians (25%), broadcasts (17.5%), institutes for government (10%), online platforms (7.5%), and others (5%). Third, key players have different characteristics in the cluster analyses. For example, all politicians except one politician belong to the largest group in the South Korea networks, while the top 10 players in other social networks do not belong to the largest group. The results show that governments and policymakers should analyze social networks based on geographical scales, regions, and topics and understand the characteristics of key players in communication networks.