2005
DOI: 10.1016/j.tox.2004.10.006
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The role of type I and type II 5′ deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status

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Cited by 42 publications
(20 citation statements)
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“…Elevated thyroidal 5Ј-deiodination accounted for the maintenance of serum T 3 concentration when DIO1 activity in liver and kidney failed to increase in rats with hypothyroxinemia generated from feeding a low-iodine diet [35]. In another study regarding hexachlorobenzene-induced alteration in the thyroid hormone status, increased conversion from T 4 to T 3 by 5Ј-deiodination in thyroid contributed in part to unaltered circulating T 3 levels in hypothyroxinemic rats [36].…”
Section: Discussionmentioning
confidence: 97%
“…Elevated thyroidal 5Ј-deiodination accounted for the maintenance of serum T 3 concentration when DIO1 activity in liver and kidney failed to increase in rats with hypothyroxinemia generated from feeding a low-iodine diet [35]. In another study regarding hexachlorobenzene-induced alteration in the thyroid hormone status, increased conversion from T 4 to T 3 by 5Ј-deiodination in thyroid contributed in part to unaltered circulating T 3 levels in hypothyroxinemic rats [36].…”
Section: Discussionmentioning
confidence: 97%
“…Exposure to HCB was also related to a concomitant decline in tT 3 and TBG, without association with TSH concentrations. HCB-treated rats usually showed a decline in fT 4 and tT 4 levels with no change in tT 3 and inconsistent effects on TSH concentrations (Alvarez et al 2005; van Raaij et al 1993). Activation of hepatic UDP-GT enzymes by HCB, followed by T 4 glucuronidation and subsequent biliary excretion, is the main mechanism explaining hypothyroidism state in rats.…”
Section: Discussionmentioning
confidence: 99%
“…The negative association of HCB with T 4 levels among Akwesasne adolescents is consistent with the literature. Numerous animal studies have demonstrated HCB-induced hypothyroidism, with T 4 levels being particularly sensitive in rats (Alvarez et al 2005; Foster et al 1993; Kleiman de Pisarev et al 1990, 1995; Rozman et al 1986; van Raaij et al 1993). Lower T 4 levels associated with HCB exposure may be attributed to peripheral disposition of T 4 (Kleiman de Pisarev et al 1989) or increased hepatic T 4 metabolism (Kleiman de Pisarev et al 1990).…”
Section: Discussionmentioning
confidence: 99%