The Role of UGT1A1*28 Mutation in Jaundiced Infants with Hypertrophic Pyloric Stenosis

Liu, Hua; Shi, Dan; P, Bishop; Gosche, John R.; May, Warren; Nowicki, Michaeł

doi:10.1203/01.pdr.0000183372.23726.ca

Cited by 19 publications

(10 citation statements)

References 22 publications

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“…If pyloric thickness is more than 2 mm but less than 3 mm, a repeat check-up might be warranted. In 2% to 5% of IHPS cases, unconjugated hyperbilirubinemia may present, but it is generally known to improve after surgery and feeding [11,12]. We also experienced this phenomenon in the patient and the jaundice improved via fluid resuscitation before surgical correction.…”

Section: Discussionmentioning

confidence: 87%

A Natural Course of an Infantile Hypertrophic Pyloric Stenosis without Adequate Surgical Procedure

Lim

Park

Yeom

et al. 2015

J Korean Assoc Pediatr Surg

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Infantile hypertrophic pyloric stenosis (IHPS) is one of the common surgical abdomen in infancy, characterized by progressive non-bilious vomiting. The etiology is unknown, but it likely develops after birth. The pylorus of the stomach becomes thick and triggers progressive vomiting. Abdominal ultrasonography (US) is widely used as a diagnostic tool. Currently, there is a rare IHPS patient with severe metabolic derangement because of general use of abdominal US and its accuracy. We experienced a natural course of a 62-day-old male infant with IHPS who was suffering from intermittent vomiting, loss of weight but had not been properly treated for 1 month. It is needed to make an effort to diagnose differentially in recurrent vomiting infant and check-up regularly, and also educate parents properly.

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Section: Discussionmentioning

confidence: 87%

A Natural Course of an Infantile Hypertrophic Pyloric Stenosis without Adequate Surgical Procedure

Lim

Park

Yeom

et al. 2015

J Korean Assoc Pediatr Surg

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“…"Olive" was not felt at any stage. Unconjugated hyperbilirubinemia, a frequent clinical association of IHPS occurring in 14% of cases, and termed as icteropyloric syndrome, was not seen [11]. The outstanding clinical picture was that of a healthy, appropriately interactive, thriving "hungry feeder and vomiter" who displayed significant post-prandial visible gastric peristalsis and radiographic evidence of delayed passage of gastric contents through pylorus in the presence of normal pyloric dimensions.…”

Section: Discussionmentioning

confidence: 99%

Could Increased Pyloric Transit time Differentiate Early Onset Infantile Hypertrophic Pyloric Stenosis: a Case Study and Review

Verma¹

2017

JPNC

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“…Hyperbilirubinaemia is the most frequent clinical association occurring in 14 percent of cases in one series [6]. HPS has also been correlated with midgut malrotation [14], joint hypermobility [15,16], congenital heart disease [7], congenital hypothyroidism [17],hernias [8,9] and other congenital diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperbilirubinaemia is one of them occurring in 14% of cases in one series [6]. Furthermore, congenital malformations, including midgut malrotation (up to 5% of infants with HPS), congenital heart disease [7], diaphragmatic [8] and hiatal [9] hernia, Meckel's diverticulum and oesophageal atresia, have also been reported [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Is there a correlation between hypertrophic pyloric stenosis and congenital abnormalities of the urinary tract in children?

2010

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Aim-Background: Numerous clinical associations and congenital abnormalities have been described in combination with hypertrophic pyloric stenosis (HPS) in infants. The correlation between HPS and congenital abnormalities has not yet been clarified. The aim of this study is to assess whether there is a common appearance of these two conditions and whether an extra testing of the urinary tract is needed. Patients and methods: Fifty-six children who had undergone surgery for HPS between 2001 and 2005 were retrospectively evaluated. History was obtained and ultrasound screening of the urinary tract was performed. Results: The ultrasound screening revealed a double renal pelvis system in one boy (1.7%). Twelve (21%) children had an incidence of urinary tract infection (UTI) and two boys (3%) had a positive history for nocturnal enuresis. There is no correlation between hypertrophic pyloric stenosis and congenital abnormalities of the urinary tract, since the difference between the incidence of congenital malformations of the urinary tract in the general population and the population with HPS is insignificant. Conclusion: We do not recommend additional testing of the urinary tract in children with HPS, but more research is required to establish whether there are functional disorders of the urinary tract in the population with HPS.

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The Role of UGT1A1*28 Mutation in Jaundiced Infants with Hypertrophic Pyloric Stenosis

Cited by 19 publications

References 22 publications

A Natural Course of an Infantile Hypertrophic Pyloric Stenosis without Adequate Surgical Procedure

A Natural Course of an Infantile Hypertrophic Pyloric Stenosis without Adequate Surgical Procedure

Could Increased Pyloric Transit time Differentiate Early Onset Infantile Hypertrophic Pyloric Stenosis: a Case Study and Review

Is there a correlation between hypertrophic pyloric stenosis and congenital abnormalities of the urinary tract in children?

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