The Role of Ultrahigh-Frequency Audiometry in the Early Detection of Systemic Drug-Induced Hearing Loss

Chauhan, Rajeev; Saxena, R. K.; Varshey, Saurabh

doi:10.1177/014556131109000506

Cited by 33 publications

(23 citation statements)

References 13 publications

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“…In accordance with previously published data the deterioration of hearing, documented using hfPTA [3,4,5,27,28], was detected at the early phases of the treatment.…”

Section: Discussionsupporting

confidence: 91%

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Genetic risk factors of cisplatin induced ototoxicity in adult patients

Talach¹,

Rottenberg²,

Gál³

et al. 2016

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Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).

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“…In accordance with previously published data the deterioration of hearing, documented using hfPTA [3,4,5,27,28], was detected at the early phases of the treatment.…”

Section: Discussionsupporting

confidence: 91%

“…Special equipment is necessary for high frequency audiometry. Since the damage to the organ of Corti caused by CDDP starts in the highest frequencies, it is necessary to find a reasonable compromise between the required sensitivity of the method and available technical means [8].…”

mentioning

confidence: 99%

Genetic risk factors of cisplatin induced ototoxicity in adult patients

Talach¹,

Rottenberg²,

Gál³

et al. 2016

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“…12,13 Nagaris et al also showed approximately half had bilaterally symmetric NIHL as in present study and 34.2% had left side predominance. 28 But it is contradictory to the study by Nair et al where right sided hearing loss was predominant. 10 The left sided asymmetry may be secondary to biological difference of a less active acoustic reflex on the left ear or may be the higher otoacoustic emission amplitude on the right side due to its more intense auditory efferent system.…”

Section: Original Articlementioning

confidence: 87%

Prevalance of Noise Induced Hearing Loss among Traffic Police Personnel of Kathmandu Metropolitan City

Shrestha

Pokharel

et al. 2012

Kathmandu Univ. Med. J.

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Background Noise induced hearing loss (NIHL) is a major preventable occupational health hazard. Objective To measure permanent threshold shift in traffic police personnel due to noise exposure and to examine whether it was associated with duration of noise exposure, years of work and risk factors. Methods Cross sectional, descriptive study conducted at Dhulikhel hospital, Kathmandu University Hospital in 110 responding traffic police personnel. Detailed history and clinical examination of ear, impedence audiometry and pure tone audiometry was performed. Results Mean age group was 29.82 years; 82(74.5%) were males and 28 (25.5%) were females. Mean duration of service is 11.86 years. Twenty six (23.6%) had tinnitus and 39(35.5%) had blocked sensation in ear. Sixty five (59.1%) worked between 10-19 years. Alcohol and smoking shows positive impact on NIHL (p value =0.00). Odds ratio with 95% confidence interval were 4.481 (1.925-10.432) and 6.578 (2.306-18.764) respectively. Among 73(66.4%) noise induced hearing loss positive cases, bilateral involvement was seen in 45 (40.9%) and unilateral in 28(25.4 %) cases. Among unilateral cases most were left sided. Hearing threshold at 4 kHz increased according to age and duration of service. Conclusion Traffic police personnel are in constant risk of noise induced hearing loss. Screening for hearing loss is recommended for people exposed to noise.DOI: http://dx.doi.org/10.3126/kumj.v9i4.6343 Kathmandu Univ Med J 2011;9(4):274-8

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“…However, it does provide guidance towards creating a roadmap that countries, such as South Africa, may aspire towards in implementing an ototoxicity monitoring programme. Similar to India [79], no programmes have been formally implemented to identify and monitor ototoxicity in patients on cancer chemotherapy in South Africa. As a result, there is no contextually relevant research to steer the implementation of an accountable and effective ototoxicity monitoring program in the country.…”

Section: Methodsmentioning

confidence: 99%

Cisplatin-Associated Ototoxicity: A Review for the Health Professional

Paken

Govender

Pillay

et al. 2016

Journal of Toxicology

115

109

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Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient's quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin's ototoxic properties and the clinical signs to identify patients at risk of developing hearing loss. English peer-reviewed articles from January 1975 to July 2015 were assessed from PubMed, Science Direct, and Ebscohost. Seventy-nine articles and two books were identified for this review, using MeSH terms and keywords such as “ototoxicity”, “cisplatin”, “hearing loss”, and “ototoxicity monitoring”. This review provides an up-to-date overview of cisplatin-associated ototoxicity, namely, its clinical features, incidence rates, and molecular and cellular mechanisms and risk factors, to health care practitioners managing the patient with cancer, and highlights the need for a team-based approach to complement an audiological monitoring programme to mitigate any further loss in the quality of life of affected patients, as there is currently no otoprotective agent recommended routinely for the prevention of cisplatin-associated ototoxicity. It also sets the platform for effective dialogue towards policy formulation and strengthening of health systems in developing countries.

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The Role of Ultrahigh-Frequency Audiometry in the Early Detection of Systemic Drug-Induced Hearing Loss

Cited by 33 publications

References 13 publications

Genetic risk factors of cisplatin induced ototoxicity in adult patients

Genetic risk factors of cisplatin induced ototoxicity in adult patients

Prevalance of Noise Induced Hearing Loss among Traffic Police Personnel of Kathmandu Metropolitan City

Cisplatin-Associated Ototoxicity: A Review for the Health Professional

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