The role of vascular endothelial growth factor and its receptor Flk-1/KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas: A preliminary study of autocrine and paracrine loops

Millanta, Francesca; Silvestri, Giuliana; Vaselli, Cristiana; Citi, Simonetta; Pisani, Graziéle Fernanda Deriggi; Lorenzi, Davide De; Poli, Alessandro

doi:10.1016/j.rvsc.2006.01.007

Cited by 57 publications

(96 citation statements)

References 26 publications

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“…In general, our findings were compatible with those of the previous studies (15,20,21). Restucci et al (21) reported that along with solid carcinoma, mixed carcinoma also has high microvessel density.…”

Section: Discussionsupporting

confidence: 93%

“…The relation between expression status of angiogenic factors and the biological behaviours of the tumours has not been fully understood in animals. It is obvious that in terms of treatment, no progress has been made with respect to the methods of angiogenesis assessment (15,20).…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, approximately 41%-53% of mammary tumours in bitches are diagnosed as malignant (17). The incidence of mammary carcinomas in dogs is three times higher than in humans (15,26). Histopatological and clinical aspects of canine mammary tumours have been widely reviewed; nevertheless, the presence of considerable variations in the biological behaviour, even among histologically malignant tumours, often does not allow an accurate prognosis using microscopic examination alone (9).…”

Section: Introductionmentioning

confidence: 99%

“…These drugs have been widely used in human medicine, but they have only been introduced in the treatment protocol of animal cancer in the USA and Europe since early 2000s (15).…”

Section: Introductionmentioning

confidence: 99%

“…However, the prognostic significance of IMD has been documented in a limited number of canine and feline neoplasms, such as mammary tumours (15,20).…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Şennazlı

Yıldırım

Arun

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The objective of this study was to investigate the correlation between different histological types and grades of canine malignant mammary tumours, tumour cell proliferation and their angiogenic activity using immunohistochemical markers. Mammary tissue samples from 47 bitches with mammary cancer were evaluated. The expression of cellular proliferation marker Ki-67 and endothelial marker Von Willebrand's factor (vWF) were immunohistochemically demonstrated. The tumours with the highest Ki-67 and vWF expressions were found to share similar histomorphological features. Simple solid carcinoma had the highest levels of Ki-67, vWF, and higher histological grade while complex carcinomas, osteosarcomas, and carcinosarcomas had the lowest ones. The differences between the expressions of Ki-67 and vWF in different tumour types were considered to be of great importance in determination of biological behaviour and prognosis of these tumours. This study is one of the few studies that evaluate these differences among the subtypes of malignant canine mammary tumours.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…These drugs have been widely used in human medicine, but they have only been introduced in the treatment protocol of animal cancer in the USA and Europe since early 2000s (15).…”

Section: Introductionmentioning

confidence: 99%

“…However, the prognostic significance of IMD has been documented in a limited number of canine and feline neoplasms, such as mammary tumours (15,20).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Şennazlı

Yıldırım

Arun

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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Tumors of the Mammary Gland

Goldschmidt

Peña

Zappulli

2016

Tumors in Domestic Animals

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149

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Evaluation of vascular endothelial growth factor gene and protein expression in canine metastatic mammary carcinomas

Raposo-Ferreira

Salvador

Terra

et al. 2016

Microsc. Res. Tech.

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Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that could be associated with the induction of endothelial cell proliferation and metastasis. In this study, we evaluated VEGF gene and protein expression in canine mammary tumors (CMT), including metastatic carcinomas, to determine if there is an influence of this marker in the malignant processes and aggressiveness of CMT. We also compared VEGF protein levels with clinicopathological features. The VEGF gene and protein expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, respectively, in normal mammary gland samples, benign mammary tumors, nonmetastatic mammary carcinomas, and metastatic mammary carcinomas. High VEGF gene and protein levels were associated with malignant tumors compared with normal mammary glands (p = 0.0089 and p < 0.0001, respectively). Benign tumors showed an increased VEGF protein expression compared with normal samples (p = 0.0467). No significant differences in VEGF gene or protein levels were detected between benign and malignant tumors or between nonmetastatic and metastatic carcinomas, suggesting an absence in the correlation of VEGF with malignant processes and aggressiveness of CMT. No correlation of VEGF expression with clinical and histopathological parameters was observed, suggesting that VEGF could be important in the beginning of the mammary gland carcinogenic process and could be related to survival time.

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The role of vascular endothelial growth factor and its receptor Flk-1/KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas: A preliminary study of autocrine and paracrine loops

Cited by 57 publications

References 26 publications

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Tumors of the Mammary Gland

Evaluation of vascular endothelial growth factor gene and protein expression in canine metastatic mammary carcinomas

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