The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid

El‐Gendy, K.S.; Aly, Nagat M.; Mahmoud, Fatma; Kenawy, Anter; El-Sebae, Abdel Khalek H.

doi:10.1016/j.fct.2009.10.003

Cited by 221 publications

(134 citation statements)

References 27 publications

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“…Subchronic exposure to atrazine at 2 or 25 μg L −1 did not change the activities of GST, SOD, CAT, or GSH-Px or the concentrations of GSH and LPO; however, subchronic exposure to 10 μg L −1 increased the activity of GST, SOD, and CAT and the LPO level. In male mice, the oxidative stress of a sublethal dose (1/10 LD 50 ) of imidacloprid revealed increased lipid peroxidation level, increased liver catalase, increased liver SOD, increased liver GSH-Px, and increased liver GST (El-Gendy et al 2010). Sometimes animals may be in stress but may have normal lipid peroxidation and antioxidant enzyme profiles.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of lipotrope-feeding on the modulation of some of the anti-oxidant enzyme profiles was observed. Such a protective effect in terms of restoring anti-oxidant enzymes activities has been noted by feeding pyridoxine for endosulfaninduced toxicity in fish (Akhtar et al 2010), propolis feeding for chlorpyrifos toxicity in fish (Yonar et al 2012), vitamin C (200 mg/100 g feed) feeding for sublethal chlorpyriphos toxicity in fish (Ozkan et al 2012) and vitamin C (200 mg/kg bw) in sublethal (1/10th of LD50) toxicity of imidacloprid in mice (El-Gendy et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Muthappa

Gupta

Yengkokpam

et al. 2014

Cell Stress and Chaperones

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An experiment was conducted to evaluate the role of different lipotropes in modulating immunity and biochemical plasticity under conditions of sublethal low-dose pesticide-induced stress in fish. Labeo rohita fish fingerlings were divided in two sets with one set of fish continuously exposed to low-dose endosulfan (1/10th of 96-h LC 50 ) for 21 days, the other was unexposed, and both sets of fish were fed with practical diets supplemented with either 2 % lecithin, 0.5 % betaine, or 0.1 % choline and compared against unsupplemented diet. Low-dose endosulfan exposure had adverse effects (P<0.05/P<0.01) on hematological profile (erythrocyte count, hemoglobin, and hematocrit), serum protein (total protein, albumin, and globulin) and lipid profile (cholesterol and triglyceride), anti-oxidative status (ascorbic acid content of muscle, liver, brain, and kidney and activity of anti-oxidative enzymes: catalase and superoxide dismutase), neurotransmission (acetylcholinesterase activity in muscle and brain), immunological attributes (WBC count, albumin to globulin ratio, phagocytic activity, and serum cortisol), and metabolic plasticity as revealed from enzyme activities (muscle lactate dehydrogenase, liver and kidney glucose-6-phosphatase dehydrogenase-G6PDH activity). Dietary lipotropes prevented these effects completely or partially and the effects were lipotrope dependent. Kinetics (maximum velocity value V max , catalytic efficiency and Michaelis constant K m ) of G6PDH enzyme from crude extracts of liver and kidney indicated inhibition due to endosulfan but lipotropes could protect enzyme and showed a stabilizing effect. The supplements also helped maintain integrity of histoarchitecture of the hepatocytes in endosulfan-exposed fish to a great extent. Feeding lipotropes to fish reared in endosulfan-free water also improved hematological and serum protein and lipid profiles and were immunostimulatory. In conclusion, dietary lipotropes, especially betaine and lecithin at the levels used, improve erythropoiesis, serum protein and lipid profile, anti-oxidant status, immunocompetence, neurotransmission, and protect the livers of L. rohita fingerlings even when continuously exposed to low-dose endosulfan.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Muthappa

Gupta

Yengkokpam

et al. 2014

Cell Stress and Chaperones

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“…Reduced glutathione is central to the cellular antioxidant defenses and acts as an important cofactor for antioxidant enzymes [44]. Under oxidative stress, glutathione is consumed by the glutathionerelated enzymes to detoxify peroxides produced because of increased lipid peroxidation [45] [46] and elevation in lipid peroxidation is a consequence of the depletion in GSH stores, which are otherwise capable of moderating the amount of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

Toson¹,

Almutairi²,

Elfalal³

et al. 2016

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Liver metastasis is a normal result in Ehrlich Ascites Carcinoma Cell (EAC) infected mice. A partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of Raphnus sativus was tested for its ability to down regulate liver metastasis of Ehrlich Ascites Carcinoma Cell (EAC) intraperitoneally implanted in albino mice. Sixty albino mice were divided equally into 4 groups. Group I mice (G1 control) were treated with physiologic saline solution for 7 days. Group 2 mice (G2) were injected with the partially purified protein. Group 3 mice (G3) were intraperitoneally inoculated with EAC cells and treated with the partially purified protein. Group 4 mice (G4) were inoculated EAC cells and treated with physiologic saline solution. The results showed a disturbance in liver functions. This disturbance was observed as a reduction in the values of serum albumin, hemoglobin, total counts of erythrocytes and platelets, total lipids in liver tissues, erythrocytes SOD activity, serum glucose, reduced glutathione (GSH) and the trace elements (Fe, Mn, Zn, and Cu) contents in liver and spleen tissues as well as the elevation of serum transaminases activities, the levels of malondialdehyde in blood, DNA and RNA of liver tissues in the infected mice (G4). On the other hand, in G3, after treatment with the partial purified protein all these parameters restored their normal values and became near from the normal group (GI). Moreover, the protein showed no toxicity towards the mice as shown in G2. It could be concluded 322that a partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of Raphnus sativus as a nature source has a promised future in controlling liver metastasis.

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“…It was also found to directly inhibit HMG-CoA reductase, the predominant enzyme in cholesterol metabolism (Khor and Ng, 2000). Vitamin C is an established antioxidant and has been demonstrated to reduce oxidative stress induced by multiple mechanisms (El-Gendy et al, 2010;Tsovolas et al, 2008). The combination of vitamins C and E has been shown to be beneficial in combating oxidative stress induced by intense exercise (Naziroglu et al, 2010) and X-ray (Kayan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

et al. 2016

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Abstract-Aim:This study is designed to investigate the effects of tocotrienol-tocopherol mixed fraction (TTMF), vitamin C and combined TTMF-vitamin C supplementations on serum lipids and biochemical markers of inflammation and endothelial activation in hypercholesterolemic subjects in the low-risk category. Materials and Methods: 78 hypercholesterolaemic subjects (total cholesterol of  5.2 mmol/L and low-density lipoprotein 3.4 -4.9 mmol/L) in the low cardiovascular risk category according to the NCEP-ATP3 criteria were recruited. They were randomized into four treatment combination groups for a period of twelve months; (1) receiving TTMF and vitamin C, (2) receiving TTMF and placebo, (3) receiving vitamin C and placebo, and (4) receiving placebo for both. Serum fasting lipid profiles and levels of high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor-, intercellular adhesion molecule, vascular cell adhesion molecule, E-selectin and homocysteine were measured at entry and multiple time points post-randomisation. Results: There were no significant differences in percentage changes of lipid profiles and inflammatory markers between treated and placebo groups for either single or combined antioxidants supplementations. Conclusion: TTMF, vitamin C and combined TTMF-vitamin C supplementations have neutral effects on lipid profiles and biochemical markers of inflammation and endothelial activation in low risk subjects, suggesting that they offer no added advantage in the low cardiovascular risk group.

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The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid

Cited by 221 publications

References 27 publications

Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

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The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid

Cited by 221 publications

References 27 publications

Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Lipotropes promote immunobiochemical plasticity and protect fish against low-dose pesticide-induced oxidative stress

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from &lt;i&gt;Raphnus sativus&lt;/i&gt; Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

Contact Info

Product

Resources

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Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell