The role of vitamin D receptor gene polymorphisms in the pathogenesis of Behçet's disease: A case‐control study in Turkish population

Dal, Nazlı Ecem; Çerçi, Pamir; Ölmez, Ümit; Keskin, Göksal

doi:10.1111/ahg.12301

Cited by 11 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Dal et al 18 examined the same gene in patients with BD in Turkish population. They found that arthritis was more frequent due to the vitamin D receptor gene rs2228570 C alleles.…”

Section: Discussionmentioning

confidence: 99%

Association between intervertebral disc degeneration and Behçet's disease

Manav

İlhan

Mercan

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

Behçet's disease (BD) is a chronic systemic vasculitis with a wide range of clinical findings. It has both autoinflammatory and autoimmune features and manifests with recurrent inflammatory attacks involving the innate immune system. Recently, autoinflammation has started to take place in the pathogenesis of intervertebral disc degeneration. The aim of this study is to evaluate the relationship between intervertebral disc degeneration and BD. We evaluated patients with BD who suffered neck or low back pain in the last 1 year. Eighty four patients underwent musculoskeletal system examination with MRI imaging of the cervical and lumbar vertebrae, and serum levels of IL6, IL8, and TNF‐α were determined. The mean age was 47.7 ± 11.5 (range 20–68) years. Cervical and/or lumbar herniation was detected in the MRI imaging of 65 (77.3%) out of 84 patients. The mean IL8 levels of the group with pain and disc herniation and the group with pain and bulging were statistically significantly higher than the other groups (p = 0.007; p = 0.045, respectively). Chronic inflammation in BD may cause disc degeneration and radicular pain to begin and progress earlier in patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between intervertebral disc degeneration and Behçet's disease

Manav

İlhan

Mercan

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…There have been a relatively large number of investigations evaluating the role of vitamin D in BD susceptibility and pathogenesis. Dal et al 68 evaluated the vitamin D receptor (VDR) gene polymorphisms in the pathogenesis of BD in our population. Since they found significant differences in some genotypes between cases with BD and controls, they concluded that these gene polymorphisms may have a possible effect on BD pathogenesis.…”

Section: The Studies Evaluating Serum Vitamin D In the Susceptibility...mentioning

confidence: 99%

Vitamin D in Behcet’s Disease, a Brief Review of the Literature

Melikoğlu¹,

Sahin²,

Melikoğlu³

2023

Eurasian J Med

View full text Add to dashboard Cite

Behcet’s disease is a chronic vasculitis of unknown etiopathogenesis. Serum vitamin D levels have been reported to be associated with a variety of inflammatory and autoimmune diseases one of which is Behcet’s disease. The previous studies about vitamin D in Behcet’s disease seem to be focused on 4 main categories; the studies evaluating serum vitamin D levels between patients with Behcet’s disease and controls, the studies evaluating serum vitamin D in the susceptibility and pathogenesis of Behcet’s disease, the studies evaluating serum vitamin D in clinical involvements and activity of Behcet’s disease, and the studies evaluating the effect of serum vitamin D replacement in Behcet’s disease. The aim of this manuscript was to evaluate the results of the studies on serum vitamin D in Behcet’s disease and review the literature.

show abstract

“…Karray et al found that the VDR gene (rs1544410 and rs2228570) polymorphism were associated with BD in Tunisian patients [141]. In a study with a Turkish cohort, the VDR gene rs1544410 A allele and rs2228570 C allele were reported to be a risk factor for BD susceptibility [142]. In a meta-analysis, the role of the four common VDR polymorphisms has been investigated and it was suggested that rs731236 polymorphism might be a risk factor for BD [143].…”

Section: Vdr Genementioning

confidence: 99%

Genetics of Behçet’s Disease

Kocaaga¹

2023

Rare Diseases - Recent Advances

View full text Add to dashboard Cite

Behçet’s disease (BD; MIM 109650) is an autoinflammatory disease characterized by with recurrent oral aphthae, genital ulcers and vasculitis involving the skin, joints, eyes, veins, arteries, nervous and gastrointestinal systems. Although the pathogenesis remains uncertain, genome-wide and validation studies have demonstrated that genetic predisposition is a major factor in disease susceptibility. Several gene polymorphisms that are involved in the response to pathogens and modulate inflammation have been associated with the pathophysiology of BD. Understanding the genetic association with BD may ensure insight into the pathogenesis and for development of targeted therapies for this autoinflammatory disease. This chapter will deal the role of genetic and epigenetic factors as contributing factors in the pathogenesis of BD.

show abstract

The role of vitamin D receptor gene polymorphisms in the pathogenesis of Behçet's disease: A case‐control study in Turkish population

Cited by 11 publications

References 51 publications

Association between intervertebral disc degeneration and Behçet's disease

Association between intervertebral disc degeneration and Behçet's disease

Vitamin D in Behcet’s Disease, a Brief Review of the Literature

Genetics of Behçet’s Disease

Contact Info

Product

Resources

About