The Role of Vitamin D in Depression: From a Curious Idea to a Therapeutic Option

Vitamin D supplementation reduces depressive symptoms in patients with chronic liver disease

“…Furthermore, our results concur with earlier studies and a meta-analysis showing inverse associations of depressive symptoms with vitamin D levels in healthy populations [8,26]. Though such an association does not prove causality, studies investigating the efficacy of vitamin D replacement therapy for depression look e albeit inconsistently e promising [27]. A recent meta-analysis of randomised controlled trials (RCTs) in fact reported the favourable effect of !800 IU/day vitamin D supplementation for the management of depression to be similar to that of anti-depressant medication when accompanied by an increase in serum 25-hydroxyvitamin D concentrations [28].…”

Clinical correlation of vitamin D in depression

“…[24][25][26] In our view the above findings may be of immense importance because the Vitamin D has been increasingly measured among nonresponding depressive patients who require inpatients facility with the expectation to offer a new therapeutic option for depression. 27 Furthermore, we have also found that vitamin D deficient participants had scored higher (more severity) on BDI II scale compared with those having sufficient vitamin D levels (>75 nmol/L). The results were in accordance to the previous work done by Penckofer S et al and Armstrong DJ et al .…”

Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study

“…Vitamin D synthesis in skin requires sunlight exposure. Low vitamin D concentrations were associated with diverse psychiatric disorders (Berk et al, 2008), and by metaanalysis, with depression (Anglin et al, 2013;Annweiler et al, 2013) and poor cognition (Balion et al, 2012). Finally, some patients with depression show anomalies in the retinal response to light (Fountoulakis 2010;Fountoulakis et al, 2005).…”