The Role of Zinc in the T-Cell Metabolism in Infection Requires Further Investigation - An Opinion

Sergi, Consolato

doi:10.3389/fimmu.2022.865504

Front. Immunol.

2022

DOI: 10.3389/fimmu.2022.865504

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The Role of Zinc in the T-Cell Metabolism in Infection Requires Further Investigation - An Opinion

Consolato Sergi

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Cited by 2 publications

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“…The improvement of nutrition and rickets is an example of the work provided by several pediatric societies advocating for fortified milk and more control on social services. The results of these enormous efforts have been impressive consolidating the concept of pediatric health care in several countries (20)(21)(22)(23). Digitalization and proper storage of the imaging in medicine are crucial.…”

mentioning

confidence: 99%

Translational pediatrics: reflections for the 21st century and beyond

Sergi¹

2022

Transl Pediatr

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mentioning

confidence: 99%

Translational pediatrics: reflections for the 21st century and beyond

Sergi¹

2022

Transl Pediatr

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Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Shen

Fang

et al. 2023

J Nanobiotechnol

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The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years. Graphical Abstract

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The Role of Zinc in the T-Cell Metabolism in Infection Requires Further Investigation - An Opinion

Cited by 2 publications

References 31 publications

Translational pediatrics: reflections for the 21st century and beyond

Translational pediatrics: reflections for the 21st century and beyond

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

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