The roles of ANRIL polymorphisms in periodontitis: a systematic review and meta-analysis

Öztürk, Ayla; Ada, Ahmet Oğuz

doi:10.1007/s00784-021-04257-0

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…For the TNF-α polymorphism, TNFA-308G/A was found to be associated with CP and AP, but no polymorphism distinguishing the two was found [ 64 , 75 ]. In a report using the polymorphisms of a long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus), as a marker for the diagnosis of CP and AP, the rs1333048 polymorphism was strongly associated with the new classification grade C (equivalent to the old classification AP) [ 76 ].…”

Section: Examination and Diagnosis For Precision Periodonticsmentioning

confidence: 99%

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi

Hayashi

Mitani

2022

JPM

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Periodontal disease, a major cause of tooth loss, is an infectious disease caused by bacteria with the additional aspect of being a noncommunicable disease closely related to lifestyle. Tissue destruction based on chronic inflammation is influenced by host and environmental factors. The treatment of periodontal disease varies according to the condition of each individual patient. Although guidelines provide standardized treatment, optimization is difficult because of the wide range of treatment options and variations in the ideas and skills of the treating practitioner. The new medical concepts of “precision medicine” and “personalized medicine” can provide more predictive treatment than conventional methods by stratifying patients in detail and prescribing treatment methods accordingly. This requires a new diagnostic system that integrates information on individual patient backgrounds (biomarkers, genetics, environment, and lifestyle) with conventional medical examination information. Currently, various biomarkers and other new examination indices are being investigated, and studies on periodontal disease-related genes and the complexity of oral bacteria are underway. This review discusses the possibilities and future challenges of precision periodontics and describes the new generation of laboratory methods and advanced periodontal disease treatment approaches as the basis for this new field.

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Section: Examination and Diagnosis For Precision Periodonticsmentioning

confidence: 99%

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi

Hayashi

Mitani

2022

JPM

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“…The Antisense Non coding RNA in the INK4 Locus ( ANRIL ), also known as CDKN2B Antisense RNA 1 ( CDKN2B-AS1 ) is located in the 9p21.3 genomic region, within CDKN2B - CDKN2A gene cluster that has been reported as a susceptibility locus for cardiovascular disease [ 73 , 74 ], cancer [ 75 ], intracranial aneurysm [ 76 ], periodontitis [ 77 ], Alzheimer’s disease [ 78 ], endometriosis [ 79 ], glaucoma [ 80 ] and type 2 diabetes [ 81 ]. The upregulation of ANRIL has been reported in patients with DR compared to healthy subjects [ 62 ].…”

Section: Long Non Coding Rnas With Increased Expression In Diabetic R...mentioning

confidence: 99%

Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?

et al. 2022

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The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopathy (DR) is the leading cause of blindness in older diabetic patients and can occur with different degrees of severity. Chronic hyperglycemia is the main determinant of the functional damage of retinal cells. The oxidative stress, inflammatory factors and vascular endothelial growth factor signaling have been widely reported as contributors of DR onset and progression, and an emerging role has been described for different classes of non-coding RNA, including several long non-coding RNAs (lncRNAs). Here, we report the main results of all research articles (i.e., 150) listed on PubMed database from 2014 to 2022 regarding the putative role of lncRNAs in DR, including small nucleolar RNA host genes (SNHGs). Particularly, in this review we describe all lncRNAs and SNHGs with altered expression in DR and related contexts, discussing their association with DR outcomes, their mechanism of action related to DR, the molecular/functional effects, as well as the biological and experimental contexts. Thus, herein we provide an overview of the current state of knowledge regarding the putative involvement of 50 lncRNAs and SNHGs in the pathogenesis of DR, highlighting their potential as therapeutic targets or biomarkers for improving the clinical management of DR.

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