The roles of Dippu-allatostatin in the modulation of hormone release in Locusta migratoria

Clark, Lisa J.; Lange, Angela B.; Zhang, J.R.; Tobe, Stephen S.

doi:10.1016/j.jinsphys.2008.03.007

Cited by 30 publications

(18 citation statements)

References 52 publications

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“…The distribution of FGLa/AST-like immunoreactivity in L. migratoria suggests these peptides have diverse physiological functions (Clark et al, 2008). Recently, FGLa/AST innervation to the locust gut was described, indicating the source of FGLa/ASTlike peptides associated with the foregut to be cell bodies within the brain, and the source of those associated with the hindgut to be…”

Section: Discussionmentioning

confidence: 99%

“…This is important as it is the digestion and metabolism of nutrients from food that provides the energy for important physiological processes such as growth, flight and reproduction. As we have shown previously that proctolin and FGLa/ASTs act as releasing factors for adipokinetic hormone I and juvenile hormone, both of which are metabolically important peptides (Clark et al, 2006b;Clark et al, 2008), it is important to understand how proctolin and FGLa/ASTs may also affect gut physiology, and thus directly affect homeostasis and the physiology of the insect. Using a variety of techniques we show that the FGLa/AST peptide family influences foregut contractions in two ways; by modulating the CPG, which controls the timing and intensity of foregut contractions, and also in a complementary fashion by a direct action on the muscle to inhibit contraction.…”

Section: Introductionmentioning

confidence: 99%

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The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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“…The type A AS has been described for many insect orders, but seems to act as true AS only in cockroaches, crickets, and termites (Stay, 2000;Yagi et al, 2008). However, Clark et al (2008) have demonstrated that a type A AS also alters the production and release of JH in the locust, Locusta migratoria. The myoinhibitory peptide (MIP)/type B AS peptides were first identified by their myoinhibitory action on locust oviduct muscle (Schoofs et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide regulators of the juvenile hormone biosynthesis (in vitro) in the beetle, Tenebrio molitor (Coleoptera, Tenebrionidae)

Abdel-latief

Hoffmann

2010

Arch Insect Biochem Physiol

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The genome of Tribolium castaneum encodes two allatostatin [AS type B; W(X)(6)Wamide and AS type C; PISCF-OH] and one allatotropin (AT) precursor, but no AS type A (FGLamide) (Tribolium Genome Sequencing Consortium, 2008: Nature 452:949-955). Here we studied the activity (in vitro) of peptides derived from these precursors on the synthesis/release of juvenile hormone (JH) III. The corpora cardiaca-corpora allata (CC-CA) complexes of adult females of another tenebrionid beetle, the mealworm Tenebrio molitor, were used. Incubating the gland complexes in a medium containing Trica-AS B3 peptide, we showed that the peptide has allatostatic function in T. molitor. The activity of the type C AS depended on the age of the test animals and their intrinsic rate of JH III biosynthesis. The Trica-AS C peptide inhibited the JH release from CA of 3-day-old females with a high intrinsic rate of JH synthesis, but activated JH release from the CA of 7-day-old females with a lower intrinsic rate of JH production. The allatotropin peptide (Trica-AT) also activated the JH release from the CA of 7-day-old females in a dose-dependent and reversible manner. Unexpectedly, a type A AS derived from the precursor of the American cockroach Periplaneta americana (Peram-AS A2b) inhibited the JH release from the CA of younger and older females in the concentration range of 10(-8) to 10(-4) M, and the effects were fully reversible in the absence of peptide. These data suggest a complex role of allatoactive neuropeptides in the regulation of JH III biosynthesis in beetles.

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“…This AST family has a conserved pentapeptide C-terminal sequence Tyr/PheXaaPheGlyLeu/Ileamide (FGLamide) and is found in numerous insect orders and in Crustacea (Table 1). This C-terminal core sequence is required for rapid and reversible inhibition of JH biosynthesis (Pratt et al 1991b;Stay et al 1991), but JH inhibition appears restricted to cockroaches, crickets, locusts, and termites (Stay and Tobe 2007;Clark et al 2008). The D. punctata AST gene was the first to be sequenced and revealed that a single open reading frame encoded a preproAST polypeptide precursor (Donly et al 1993).…”

Section: The Fglamide-related-ast Familymentioning

confidence: 99%

“…This peptide is active as a myoinhibitor when tested in a locust oviduct assay. AST-specific immunoreactivity demonstrated innervation of the locust CA (Veelaert et al 1995) and FGLa/ASTs appear to regulate the CA when the rate of JH biosynthesis is high (Clark et al 2008). The nematode Caenorhabditis elegans Maupas, 1900 genome has two genes nlp-5 and nlp-6 that express AST-like peptides, but these differ from the C-terminal consensus, terminating in MGLa, MGFa, FGFa, and MGLa (Table 1).…”

Section: The Fglamide-related-ast Familymentioning

confidence: 99%

Families of allatoregulator sequences: a 2011 perspective¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

BendenaWilliam

TobeStephen

2012

Can. J. Zool.

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Three different peptide families have been named "allatostatins" (ASTs), based on their initial purifications which were based on their ability to inhibit juvenile hormone (JH) biosynthesis. These include (i) a family of peptides that have a consensus C-terminal sequence Y/FXFGL-NH 2 ; (ii) a family of peptides with a conserved C-terminal sequence W(X) 6 W-NH 2 ; and(iii) a family of peptides with C-terminal sequence PISCF, some of which are C-terminally-amidated. Each allatostatin family has functions distinct and apart from the inhibition of JH biosynthesis. A peptide family known as the "allatotropins" serve to stimulate JH biosynthesis. This family of peptides also has been proven to exert multiple effects dependent on the species in question. Genome and peptidome projects are uncovering new members of these families and it is clear that these structures are not just confined to Insecta but are found in a range of invertebrates. The receptors for these neuropeptides have been identified and tested experimentally for specific ligand binding. The Y/FXFGLa-ASTs exert their action through galanin-like receptors, W(X) 6 Wa-ASTs through a sex peptide-binding receptor, and PISCF-ASTs through somatostatin-like receptors. These receptors are conserved through evolutionary time and are being identified in numerous invertebrates by way of genome projects.Key words: allatostatin, allatotropin, juvenile hormone, muscle contraction, neuropeptides, neuropeptide receptors, insects, crustaceans, arthropods.Résumé : Trois familles différentes de peptides portent le nom d'« allatostatines » (AST) d'après leurs purifications initiales basées sur leur capacité d'inhiber la biosynthèse de l'hormone juvénile (JH). Elles incluent (i) une famille de peptides qui possèdent une séquence consensus C-terminale Y/FXFGL-NH 2 , (ii) une famille de peptides avec une séquence C-terminale conservée W(X) 6 W-NH 2 et (iii) une famille de peptides avec une séquence C-terminale PISCF, dont certains sont amidatées sur l'extrémité C-terminale. Chaque famille d'allatostatines possède des fonctions distinctes et additionnelles à l'inhibition de la synthèse de l'hormone juvénile. Une famille de peptides connus sous le nom d'« allatotropines » sert à stimuler la synthèse de la JH. Cette famille de peptides produit aussi des effets multiples selon l'espèce concernée. Des projets sur le génome et le peptidome découvrent de nouveaux membres de ces familles et il est clair que ces structures ne se retrouvent pas seulement chez les insectes, mais aussi chez une gamme d'invertébrés. Les récepteurs de ces neuropeptides ont été identifiés et ont été testé expérimentalement pour des liaisons spécifiques au ligand. Les AST-Y/FXFGLa exercent leur action par des récepteurs de type galanine, les AST-W(X)6Wa par un récepteur liant un peptide sexuel et les AST-PISCF par des récepteurs de type somatostatine. Ces récepteurs sont conservés au cours de l'évolution et sont présentement retrouvés chez de nombreux invertébrés dans le cadre des projets de génome.

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The roles of Dippu-allatostatin in the modulation of hormone release in Locusta migratoria

Cited by 30 publications

References 52 publications

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Neuropeptide regulators of the juvenile hormone biosynthesis (in vitro) in the beetle, Tenebrio molitor (Coleoptera, Tenebrionidae)

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