Neuropeptide regulators of the juvenile hormone biosynthesis (in vitro) in the beetle, <i>Tenebrio molitor</i> (Coleoptera, Tenebrionidae)

Abdel-latief, Mohatmed; Hoffmann, Klaus H.

doi:10.1002/arch.20359

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…Orthologs are found in other lepidopteran, dipteran and coleopteran species (Li et al, 2006). In several insects, C-type or C-type-like ASTs can have both allatostatic and allatotropic properties, depending on the age of the animal (Abdel-Latief et al, 2004; Clark et al, 2008; Griebler et al, 2008; Abdel-Latief and Hoffmann, 2010). In Diptera two AST-C receptors have been characterized for Drosophila using Xenopus oocytes (Kreienkamp et al, 2002) and for Aedes using HEK cells (Mayoral et al, 2010).…”

Section: Deorphanized Neuropeptide Receptorsmentioning

confidence: 99%

More than two decades of research on insect neuropeptide GPCRs: an overview

Caers¹,

Verlinden²,

Zels³

et al. 2012

Front. Endocrin.

154

143

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This review focuses on the state of the art on neuropeptide receptors in insects. Most of these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation of virtually all physiological processes during an insect's life. More than 20 years ago a milestone in invertebrate endocrinology was achieved with the characterization of the first insect neuropeptide receptor, i.e., the Drosophila tachykinin-like receptor. However, it took until the release of the Drosophila genome in 2000 that research on neuropeptide receptors boosted. In the last decade a plethora of genomic information of other insect species also became available, leading to a better insight in the functions and evolution of the neuropeptide signaling systems and their intracellular pathways. It became clear that some of these systems are conserved among all insect species, indicating that they fulfill crucial roles in their physiological processes. Meanwhile, other signaling systems seem to be lost in several insect orders or species, suggesting that their actions were superfluous in those insects, or that other neuropeptides have taken over their functions. It is striking that the deorphanization of neuropeptide GPCRs gets much attention, but the subsequent unraveling of the intracellular pathways they elicit, or their physiological functions are often hardly examined. Especially in insects besides Drosophila this information is scarce if not absent. And although great progress made in characterizing neuropeptide signaling systems, even in Drosophila several predicted neuropeptide receptors remain orphan, awaiting for their endogenous ligand to be determined. The present review gives a précis of the insect neuropeptide receptor research of the last two decades. But it has to be emphasized that the work done so far is only the tip of the iceberg and our comprehensive understanding of these important signaling systems will still increase substantially in the coming years.

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Section: Deorphanized Neuropeptide Receptorsmentioning

confidence: 99%

More than two decades of research on insect neuropeptide GPCRs: an overview

Caers¹,

Verlinden²,

Zels³

et al. 2012

Front. Endocrin.

154

143

View full text Add to dashboard Cite

show abstract

“…In the genome of T. castaneum an AT-like peptide (Trica-ATL) is present (Tribolium Genome Sequencing Consortium, 2008;Li et al, 2008). This Trica-ATL was shown to activate JH release from the CA of 7-day old female Tenebrio molitor beetles in a dose-dependent and reversible manner (Abdel-latief and Hoffmann, 2010), suggesting that in Tribolium the ATL peptide functions as the endogenous AT.…”

Section: Introductionmentioning

confidence: 98%

Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum

Vuerinckx

Verlinden

Lindemans

et al. 2011

Insect Biochemistry and Molecular Biology

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“…Additional functions for Manse-AT in other lepidopterans include the stimulation of JH biosynthesis by the larval CA in some, but not all, lepidopteran insects Li et al, 2002), stimulation of foregut contractions in Helicoverpa armigera and Lacanobia oleracea (Duve et al, 1999(Duve et al, , 2000, and the stimulation of ventral diaphragm oscillation in Pseudaletia unipuncta (Koladich et al, 2002). Additional activities were described for Manse-AT, or the endogenous homolog, in other insects including the stimulation of JH biosynthesis by CA of insects from the orders Diptera (Tu et al, 2001;Veenstra and Costes, 1999), Hymenoptera (Rachinsky and Feldlaufer, 2000), Dermaptera (Rankin et al, 2005) and Coleoptera (Abdel-latief and Hoffmann, 2010); the stimulation of myotropic activity in insects from the orders Orthoptera (Paemen et al, 1991), Dictyoptera (Rudwall et al, 2000), Coleoptera (Spittaels et al, 1996), and Hemiptera (Santini and Ronderos, 2007); and the photic entrainment of the circadian clock in an insect from the order Dictyoptera (Petri et al, 2002). Like many neuropeptides, Manse-AT has multiple functions, and its primary role may differ depending on the developmental stage of the insect.…”

Section: Introductionmentioning

confidence: 98%

Isolation and functional characterization of an allatotropin receptor from Manduca sexta

Horodyski

Verlinden

Filkin

et al. 2011

Insect Biochemistry and Molecular Biology

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Manduca sexta allatotropin (Manse-AT) is a multifunctional neuropeptide whose actions include the stimulation of juvenile hormone biosynthesis, myotropic stimulation, cardioacceleratory functions, and inhibition of active ion transport. Manse-AT is a member of a structurally related peptide family that is widely found in insects and also in other invertebrates. Its precise role depends on the insect species and developmental stage. In some lepidopteran insects including M. sexta, structurally-related AT-like (ATL) peptides can be derived from alternatively spliced mRNAs transcribed from the AT gene. We have isolated a cDNA for an AT receptor (ATR) from M. sexta by a PCR-based approach using the sequence of the ATR from Bombyx mori. The sequence of the M. sexta ATR is similar to several G protein-coupled receptors from other insect species and to the mammalian orexin receptor. We demonstrate that the M. sexta ATR expressed in vertebrate cell lines is activated in a dose-responsive manner by Manse-AT and each Manse-ATL peptide in the rank order ATL-I > ATL-II > ATL-III > AT, and functional analysis in multiple cell lines suggest that the receptor is coupled through elevated levels of Ca(2+) and cAMP. In feeding larvae, Manse-ATR mRNA is present at highest levels in the Malpighian tubules, followed by the midgut, hindgut, testes, and corpora allata, consistent with its action on multiple target tissues. In the adult corpora cardiaca--corpora allata complex, Manse-ATR mRNA is present at relatively low levels in both sexes.

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Neuropeptide regulators of the juvenile hormone biosynthesis (in vitro) in the beetle, Tenebrio molitor (Coleoptera, Tenebrionidae)

Cited by 24 publications

References 39 publications

More than two decades of research on insect neuropeptide GPCRs: an overview

More than two decades of research on insect neuropeptide GPCRs: an overview

Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum

Isolation and functional characterization of an allatotropin receptor from Manduca sexta

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