The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer

Xu, Zhijie; Peng, Bi; Kang, Fanhua; Zhang, Wenqin; Xiao, Muzhang; Li, Jianbo; Hong, Qianhui; Cai, Yuan; Liu, Wei; Yan, Yuanliang; Peng, Jinwu

doi:10.3389/fcell.2022.877254

Cited by 9 publications

(5 citation statements)

References 60 publications

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“…ADH1B and PLAAT4 were identified as favorable genes for survival in our study. As a drug metabolism-related gene, the high level of ADH1B expression has been reported to be connected to a good prognosis in ovarian cancer, along with its positive correlation with multiple immune cells [ 52 ]. As for PLAAT4, whose another familiar name is RARRES3, it is commonly believed to function as a tumor suppressor and is related to tumor differentiation [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma

Liu,

Lu,

Liu

et al. 2024

Cell Biosci

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Background Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO. Method Three databases, including NCBI-GEO, TCGA, and MET-500, separately provide single-cell RNA sequencing data, bulk RNA sequencing profiles of MESO, and RNA sequencing information on bone metastatic tumors. Dimensionality reduction and clustering analysis were leveraged to acquire fibroblast subtypes in the MESO microenvironment. The fibroblast differentiation-related genes (FDGs), which were associated with survival and subsequently utilized to generate the MESO categorization and prognostic prediction model, were selected in combination with pseudotime analysis and survival information from the TCGA database. Then, regulatory network was constructed for each MESO subtype, and candidate inhibitors were predicted. Clinical specimens were collected for further validation. Result A total of six fibroblast subtypes, three differentiation states, and 39 FDGs were identified. Based on the expression level of FDGs, three MESO subtypes were distinguished in the fibroblast differentiation-based classification (FDBC). In the multivariate prognostic prediction model, the risk score that was dependent on the expression level of several important FDGs, was verified to be an independently effective prognostic factor and worked well in internal cohorts. Finally, we predicted 24 potential drugs for the treatment of MESO. Moreover, immunohistochemical staining and statistical analysis provided further validation. Conclusion Fibroblast differentiation-related genes (FDGs), especially those in low-differentiation states, might participate in the proliferation and invasion of MESO. Hopefully, the raised clinical subtyping of MESO would provide references for clinical practitioners.

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Section: Discussionmentioning

confidence: 99%

A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma

Liu,

Lu,

Liu

et al. 2024

Cell Biosci

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“…In addition, after analyzing expression profiles of GEO database, ALDH3A2 is overexpressed in gastric cancer, and survival analysis suggests that patients with low ALDH3A2 expression have significantly shorter overall survival than those with high ALDH3A2 expression, indicating that ALDH3A2 can serve as an independent predictor and a prognostic marker for gastric cancer 31 . In ovarian cancer, ADH1B is found significantly down-regulated in ovarian cancer cells and tissues after integrated bioinformatics analysis and western blot assay 32 . DPT is a candidate protein biomarker in tissue lysates of metastatic melanoma and is identified in tissue lysates of malignant melanoma by selected reaction monitoring 33 .…”

Section: Discussionmentioning

confidence: 99%

ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma

Lei,

Liao,

Wang

et al. 2024

Sci Rep

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Melanoma is a malignant skin tumor. This study aimed to explore and assess the effect of novel biomarkers on the progression of melanoma. Differently expressed genes (DEGs) were screened from GSE3189 and GSE46517 datasets of Gene Expression Omnibus database using GEO2R. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted based on the identified DEGs. Hub genes were identified and assessed using protein–protein interaction networks, principal component analysis, and receiver operating characteristic curves. Quantitative real-time polymerase chain reaction was employed to measure the mRNA expression levels. TIMER revealed the association between aldehyde dehydrogenase 2 (ALDH2) and tumor immune microenvironment. The viability, proliferation, migration, and invasion were detected by cell counting kit-8, 5-ethynyl-2′-deoxyuridine, wound healing, and transwell assays. Total 241 common DEGs were screened out from GSE3189 and GSE46517 datasets. We determined 6 hub genes with high prediction values for melanoma, which could distinguish tumor samples from normal samples. ALDH2, ADH1B, ALDH3A2, DPT, EPHX2, and GATM were down-regulated in A375 and SK-MEL-2 cells, compared with the human normal melanin cell line (PIG1 cells). ALDH2 was selected as the candidate gene in this research, presenting a high diagnostic and predictive value for melanoma. ALDH2 had a positive correlation with the infiltrating levels of immune cells in melanoma microenvironment. Overexpression of ALDH2 inhibited cell viability, proliferation, migration, and invasion of A375/SK-MEL-2 cells. ALDH2 is a new gene biomarker of melanoma, which exerts an inhibitory effect on melanoma.

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“…ADH1B enhances various factors that additionally facilitate the progression of ovarian cancer[ 41 ]. The drug metabolism-associated gene ADH1B and its interactive network are crucial for immune regulation and therapeutic responses[ 42 ]. ADH1B downregulation has been observed in ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

Zhang,

Chu,

Ding

2024

World J Clin Cases

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BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome. This study presents a rare association between chromosome 4q abnormalities and fallopian tube high-grade serous carcinoma (HGSC) in a young woman. CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion. Upon arrival at the emergency room, her abdomen appeared ovoid and distended with palpable shifting dullness. Ascites were identified through abdominal ultrasound, and computed tomography revealed an omentum cake and an enlarged bilateral adnexa. Blood tests showed elevated CA-125 levels. Paracentesis was conducted, and immunohistochemistry indicated that the cancer cells favored an ovarian origin, making us suspect ovarian cancer. The patient underwent debulking surgery, which led to a diagnosis of stage IIIC HGSC of the fallopian tube. Subsequently, the patient received adjuvant chemotherapy with carboplatin and paclitaxel, resulting in stable current condition. CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC. UBE2D3 may affect crucial cancer-related pathways, including P53, BRCA, cyclin D, and tyrosine kinase receptors, thereby possibly contributing to cancer development. In addition, ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.

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The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer

Cited by 9 publications

References 60 publications

A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma

A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma

ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

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