The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

Yang, Min; Weng, Tingting; Zhang, Wei; Zhang, Manjia; He, Xin; Han, Chunmao; Wang, Xingang

doi:10.3389/fcell.2021.720879

Cited by 13 publications

(14 citation statements)

References 200 publications

(216 reference statements)

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“…Epithelial cell differentiation and hair pigmentation occur during this stage. The duration of the anagen stage determines hair length and is associated with the continuous proliferation and differentiation of stromal cells at the base of hair follicles [ 11 , 13 , 14 ]. Moreover, there is substantial variation in anagen duration according to body region: up to 6 years in the scalp, 1 to 3 months in the arms, 4 to 6 months in the legs, and 1 to 2 months in the thighs.…”

Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

“…When hair follicles enter the catagen stage, hair usually stops growing and, at the end of this phase, the hair follicles have atrophied. Therefore, the catagen stage starts when the supply of matrix cells declines, leading to a slowdown in the differentiation of the hair shaft and the inner root sheath (apoptosis-driven regression) [ 13 , 14 ]. During catagen, hair follicle degeneration is highly regulated, and a large number of keratinocytes from the hair follicle begin to undergo programmed death.…”

Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

“…This stage is characterized by low biological activity of the follicle and a drop in hair shaft. Telogen duration changes according to body region: 2 to 4 months in the scalp, 2 and a half months in the chest, 2 to 4 months in the arms, and 3 to 6 months in the legs [ 11 , 13 , 14 ]. The follicle remains in the telogen stage until it is reactivated.…”

Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

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Hirsutism, Normal Androgens and Diagnosis of PCOS

et al. 2022

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Hirsutism is defined as the presence of terminal hair with male pattern distribution in women. While in the general population, hirsutism affects around 4–11% of women, it is the main manifestation of hyperandrogenism in women with polycystic ovary syndrome (PCOS), with a prevalence estimated at 65–75%. Hirsutism in PCOS is associated with both androgen excess and individual response of the pilosebaceous unit to androgens. The modified Ferriman–Gallwey (mFG) scoring system has been widely used in clinical practice to visually score excessive terminal hair, thus standardizing hirsutism evaluation and facilitating data comparison. Although a universal mFG score cutoff would be useful for comparisons, ethnic variations, as well as skin type and other factors, should be considered when evaluating hirsutism in distinct populations. In turn, androgen levels, measured by conventional techniques, have been shown to correlate poorly with the severity of hirsutism. Indeed, while most women with PCOS and hirsutism also have higher than reference values for serum androgen levels, some of them may not present with biochemical hyperandrogenism, representing a challenge to the diagnosis of PCOS. In this article, we critically review this not uncommon condition in women with PCOS presenting with hirsutism but normal androgen levels.

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Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

Section: Hirsutism and Hair Follicle Cyclingmentioning

confidence: 99%

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Hirsutism, Normal Androgens and Diagnosis of PCOS

et al. 2022

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“…Unlike messenger RNAs (mRNAs), which do not encode proteins, ncRNAs are ubiquitous throughout the human genome ( Yang et al, 2021b ). ncRNAs play an essential regulatory role in various biological processes such as cell proliferation, epigenetic modification, and cell apoptosis ( Yang et al, 2021b ). The top three most commonly described ncRNA molecules are miRNAs, long ncRNAs (lncRNAs), and circular RNAs (circRNAs) ( Smith et al, 2021 ).…”

Section: The Role Of Extracellular Vesicles-derived From Neurons/neur...mentioning

confidence: 99%

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

Kang

Xin

et al. 2022

Front. Pharmacol.

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Neurons and neurogliocytes (oligodendrocytes, astrocytes, and microglia) are essential for maintaining homeostasis of the microenvironment in the central nervous system (CNS). These cells have been shown to support cell-cell communication via multiple mechanisms, most recently by the release of extracellular vesicles (EVs). Since EVs carry a variety of cargoes of nucleic acids, lipids, and proteins and mediate intercellular communication, they have been the hotspot of diagnosis and treatment. The mechanisms underlying CNS disorders include angiogenesis, autophagy, apoptosis, cell death, and inflammation, and cell-EVs have been revealed to be involved in these pathological processes. Ischemic stroke is one of the most common causes of death and disability worldwide. It results in serious neurological and physical dysfunction and even leads to heavy economic and social burdens. Although a large number of researchers have reported that EVs derived from these cells play a vital role in regulating multiple pathological mechanisms in ischemic stroke, the specific interactional relationships and mechanisms between specific cell-EVs and stroke treatment have not been clearly described. This review aims to summarize the therapeutic effects and mechanisms of action of specific cell-EVs on ischemia. Additionally, this study emphasizes that these EVs are involved in stroke treatment by inhibiting and activating various signaling pathways such as ncRNAs, TGF-β1, and NF-κB.

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“…The short non-coding sub-type microRNAs (miRNAs) are implicated in the temporal- and spatial-specific regulation of all body organs and tissues, including skin morphogenesis and hair follicle cycling and growth [ 8 , 9 ]. Recent evidence highlighted the importance of exploring this type of non-coding RNA to unravel the underlying pathophysiological mechanisms of AA and to discover novel biomarkers that identify its severity, differentiate its subtypes, or predict the therapeutic response [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case–Control Study

Faisal

Toraih

Atef

et al. 2022

Genes

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Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for the first time, the miR-17-92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. We also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) and the available clinical data. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated for each genetic association model. The upregulation of miR-17 was observed in the serum of patients with alopecia compared to controls (p-value = 0.004). The ROC curve showed high diagnostic performance of miR-17 in differentiating between patients and controls (AUC = 0.85, p-value < 0.001). rs4284505*A/G heterozygotes were more susceptible to the disease (OR = 1.57, 95% CI = 1.01–2.45) under the over-dominant model. Interestingly, patients with the rs4284505*G/G genotype had a higher level of miR-17 than those with the A/A and A/G genotypes. The G/G genotype was associated with the severe phenotype (p-value = 0.038). A/G carriers were the youngest (p-value < 0.001), had more frequent scalp infection (p-value = 0.006), exhibited the worst dermatology life quality index score (p-value = 0.037), and responded less to treatment (p-value = 0.033). In conclusion, MIR17HG expression and the rs4284505 variant were significantly associated with AA and could play a role in pathogenesis and phenotype in the Egyptian population. Further multi-center studies in other ethnicities are warranted to replicate the findings.

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The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

Cited by 13 publications

References 200 publications

Hirsutism, Normal Androgens and Diagnosis of PCOS

Hirsutism, Normal Androgens and Diagnosis of PCOS

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case–Control Study

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