The rs1058587 of growth differentiation factor 15 increased the development and mortality risk of end-stage renal disease

Abstract

Background Growth differentiation factor 15 (GDF-15) is a member of transforming growth factor β (TGF- β). Recent studies have shown that the serum level of GDF-15 increased and was associated with the occurrence and progression of the many diseases. However, the effect of GDF15 variants on end-stage renal disease (ESRD) is still unclear. The study was to explore the effect of GDF15 rs 1058587 on the susceptibility to ESRD and mortality risk of ESRD. Methods A total of 296 ESRD patients and 300 healthy individuals were enrolled. All the patients were followed-up for 3 years. The genotype of GDF-15 rs 1058587 was determined PCR amplification and Sanger sequencing. The baseline serum GDF-15 level was measured by enzyme-linked immunosorbent assay (ELISA). Results The frequency of G gene in ESRD patients was higher in ESRD patients than in controls (30.14% vs. 25.17%, P =0.027). The patients with CG/GG genotype had higher mortality risk in the dominant model (CG+GG vs. CC, OR= 1.708, 95% CI: 1.288 - 2.461, P = 1.00×10 -3 ). Multivariate analysis showed that age > 60 years, total cholesterol > 6 mmol/L, and genotype GG were independent risk factors for mortality in patients with ESRD (P <0.05), and survival analysis informed us that the three-year overall survival of patients with GG genotype was significantly lower than other genotype patients. Conclusions The G allele or CG/GG genotype of GDF15 was associated with higher susceptible risk of ESRD and the genotype GG was an independent risk factor for overall mortality in patients with ESRD.

Association between SNPs(rs1058587 and rs1054564) in GDF15 Gene and Development of Prostate Diseases

“…When compared healthy control with patients GDF15 levels were higher in people with metastatic prostatic cancer, in keeping with the current study, this information. To PCa patients that were restricted to specific organs, (Gronberg et al,2015 ;Li et al,2020;and Brenire et al,2019). Winand et al,2014 GDF15 may potentially act as a prognostic marker.…”