The rs1625579 T&gt;G polymorphism in the <em>miRNA-137</em> gene confers a risk of early-onset Kawasaki disease in a southern Chinese population

Abstract

BackgroundKawasaki disease (KD) mainly manifests as excessive inflammation and vascular endothelial cell injury. This disease generally occurs in children younger than 5 years of age and is more severe in children younger than 12 months. KD affects males and females at a ratio of 1.5:1. Polymorphisms of the rs1625579 locus in the miR-13 gene are associated with schizophrenia susceptibility, and high glucose-induced upregulation of miR-137 in vascular endothelial cells promotes monocyte chemotaxis and inflammatory cytokine secretion in gestational diabetes mellitus. However, researchers have not reported whether rs1625579 is associated with KD susceptibility or onset. Therefore, we investigated the relationship between the miRNA-13 rs1625579 T>G polymorphism and KD susceptibility.MethodsTaqMan real-time polymerase chain reaction was applied to determine the genotypes of 532 patients with KD (365 males and 167 females) and 623 control subjects (402 males and 221 females).ResultsComparison of all cases with all controls revealed that the rs1625579 T>G polymorphism was not associated with KD susceptibility. However, a subgroup analysis revealed that subjects with the rs1625579 TG/GG genotypes exhibited a significantly higher onset risk for KD before 12 months of age than carriers of the TT genotype (adjusted age and gender odds ratio=1.99, 95% CI=1.04–3.83; P=0.039).ConclusionOur results indicate that the rs1625579 T>G polymorphism confers a risk of early-onset KD in southern Chinese children.

Association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children

“…18 We found that miRNA-137 rs1625579 T>G is associated with the onset of Kawasaki disease in the same population in children younger than 1 year old. 16 To our knowledge, this report is the first on the association of miRNA-196a2 rs11614913 T>C with Kawasaki disease susceptibility among children in South China.…”

“…The control group was composed of 623 healthy Chinese children who went to the hospital for physical examination in the same period. [16][17][18] Peripheral venous blood was taken from each child to extract DNA.…”

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

“…All participants recruited were unrelated Chinese Han individuals from southern China. A total of 623 healthy controls and 532 patients diagnosed with KD were recruited from January 2012 to January 2017 as we described previously . Two milliliters of fresh blood was collected from each participant, and 200 µL of each blood sample was employed to extract DNA.…”

The rs6505162 C>A polymorphism in themiRNA-423gene exhibits a protective element of coronary artery in a southern Chinese population with Kawasaki disease

“…The groups mentioned above are based on American Heart Association (AHA) and can be concretely grouped according to coronary artery and age. (27, 28)SAS software (version 9.4; SAS Institute, Cary, NC) in motion carried out all Statistical analyses quickly.…”