The rs9939609 polymorphism in the fat mass and obesity associated (<i>FTO</i>) gene is associated with obesity in Tunisian population

Halima, Meriam Ben; Kallel, Amani; Baara, Abir; Wafi, Safa Ben; Sanhagi, Haifa; Slimane, H.; Jemaa, Riadh; Feki, Moncef

doi:10.1080/1354750x.2018.1499129

Cited by 12 publications

(8 citation statements)

References 41 publications

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“…In addition to the physiological multiplicity, this same perspective must be kept in mind for the multiplicity of genes (besides PAPR) which may be involved in weight loss. In addition, it is necessary to investigate other genes (isolated or associated) which have been demonstrated to be involved in obesity such as FTO (Ben Halima et al, 2018), Melanocortin 4 Receptor -MC4R (Resende et al, 2017), Adenovirus 36 (Zhou et al, 2018) and beta 2 adrenoceptor-ADRB2 (Daghestani et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

et al. 2020

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The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3-5 sessions, 40-60 min per session, and intensity between the aerobic and anaerobic threshold) (experimental group n = 53) or were part of the control group (n = 16). They were tested for aerobic capacity (ergospirometry), body composition (DXA), abdomen, waist and hip circumferences and nutritional assessment before and 48 h after the experimental protocol. Two-way repeated measures ANOVA test was used to verify possible differences in variables between the experimental vs. control groups or Pro/Pro vs. Pro/Ala groups, and the Chi-squared test was used to verify the distribution of responders and non-responders according to genotype (p < 0.05). Frequencies of 75.5% Pro/Pro (n = 40) and 24.5% Pro/Ala (n = 13) were found, without any occurrence of the recessive homozygote. Body fat reduction was initially confirmed compared to a control group which did not exercise (n = 16; 29.1 ± 8.8 years), so that the exercise group obtained a reduction of −1.3 kg vs. −0.3 kg in the control group (p = 0.03). When they were divided by genotype, there were significant changes in fat mass (−1.3 ± 2.1 kg; p = 0.00), lean mass (0.6 ± 1.5 kg; p = 0.02), fat percentage (−1.3 ± 1.6; p = 0.00), waist circumference (−2.2 ± 2.9 cm; p = 0.00), abdomen circumference (−3.3 ± 3.6 cm; p = 0.00) and hip circumference (−2.7 ± 2.7 cm; p = 0.00) for Pro/Pro genotypes; and fat mass (−1.1 ± 1.7 kg; p = 0.04), fat percentage (−0.9 ± 1.5; p = 0.04), abdomen circumference (−3.9 ± 3.5 cm; p = 0.00) and hip circumference (−1.8 ± 1.8 cm; p = 0.00) for Pro/Ala genotypes, without any group

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Section: Discussionmentioning

confidence: 99%

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

et al. 2020

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“…However, as an important nding in this study, AA genotype was found to be more frequent in females (Table 1). There are some studies in which FTO rs9939609 polymorphism is common in females and/or in women the risk allele was more likely to confer susceptibility to obesity [23][24][25]. This situation is often attributed to the high amount of fat tissue in females physiologically.…”

Section: Discussionmentioning

confidence: 99%

Preliminary findings on the relationship between gender, FTO rs9939609, leptin & ghrelin levels and eating behaviours of adults

Ağagündüz

Karadağ

2020

Preprint

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Background The single nucleotide polymorphisms (SNPs) and mutations in the first intron of the fat mass and obesity-associated (FTO) gene (rs9939609) have been reported to be associated with obesity and eating behaviour in children and adults in widespread populations. This study was conducted to determine the relationship between FTO gene polymorphism and eating behaviour in adults with different genders. Methods The present study included 200 participants (100 males,100 females) aged 18-65 years, who were genotyped for FTO gene (rs9939609) polymorphism. Eating behaviour were evaluated via revised 18-item of the three-factor eating questionnaire(TFEQ-R18). Serum leptin& ghrelin were analysed. ABI TaqMan SNP Genotyping Assays (LightCycler 480 System, Roche) was used to determine the intronic FTO gene rs9939609 (T/A) SNPs. Results Total 68.4% of individuals with AA genotype which was homozygote risky genotype for obesity were female and 31.6% were male(p<0.05). When eating behaviour scores of individuals according to genders, the difference between the cognitive restraint scores (M:16.7±2.74 vs. F:16.1±2.34; p<0.05) and emotional eating score(M:10.2±2.26 vs. F:8.5±2.84) was statistically significant(p<0.05). However, there was no statistically significant difference between the total scores of the TFEQ-R18 of males and females (p>0.05). When examining eating behaviour scores of individuals according to genotypes; it was found that no statistically significant difference between the sub-dimensions and total scores of TFEQ-R18. However, total score of TFEQ-R18 was negatively associated with the serum leptin in females with AA genotype(p<0.05), and positively associated with the serum ghrelin levels in males with TT genotype(p<0.05). Conclusion It was determined that eating behaviours in adults differed by gender rather than genotypes of FTO gene (rs9939609) polymorphism and gender was important factor for eating behaviour related to FTO gene rs9939609 genotypes in association with serum leptin-ghrelin level.

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“…The gene encoding IL-32 protein is located on chromosome 16p13.3 and contains six exons. Several SNPs have been studied in various diseases (5,(11)(12)(13). The polymorphism rs45499297 is located in the promoter region of the IL32 gene, characterized by a change from T to C. However, the association between this polymorphism and BMI, fat percentage, and lipid profile has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

Pérez¹,

Becerra-Ruiz²,

García-Aviña³

et al. 2022

Nutr Hosp

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The rs9939609 polymorphism in the fat mass and obesity associated (FTO) gene is associated with obesity in Tunisian population

Abstract: The rs9939609 polymorphism of FTO gene is associated with obesity, especially obesity class III in women.

Cited by 12 publications

References 41 publications

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

Preliminary findings on the relationship between gender, FTO rs9939609, leptin & ghrelin levels and eating behaviours of adults

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

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The rs9939609 polymorphism in the fat mass and obesity associated (FTO) gene is associated with obesity in Tunisian population

Abstract: The rs9939609 polymorphism of FTO gene is associated with obesity, especially obesity class III in women.

Cited by 12 publications

References 41 publications

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial

Preliminary findings on the relationship between gender, FTO rs9939609, leptin &amp; ghrelin levels and eating behaviours of adults

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

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Preliminary findings on the relationship between gender, FTO rs9939609, leptin & ghrelin levels and eating behaviours of adults